Discover and read the best of Twitter Threads about #Lifespan
Most recents (10)
🛑30 yılı geçen bir zamandır uzun yaşam, #lifespan #LONGEVITY sağlıklı yaşam ile uğraşıyorum. Biohacker bile sayılabilirim. Kendi üzerimde DMSA(dimercapto succinic acid)+Alpha Lipoic Acid saatlik zaman kombinasyonu yapmışlığım var. Bu siklusu rahmetli Prof. Dr. Ahmet Aydın
(1)
(1)
ile beraber Cerrahpaşa Adli Tıp Anabilim dalında yapmıştık.
Zaman zaman buradan sağlıklı yemekler paylaşıyorum.
Beni yakından takip edenlerin bildiği gibi pesketaryanım yani kırmızı et, beyaz et, hayvansal bir gıda almıyorum. Sadece balık ve yumurta yiyorum.
Buğday-buğday
(2)
Zaman zaman buradan sağlıklı yemekler paylaşıyorum.
Beni yakından takip edenlerin bildiği gibi pesketaryanım yani kırmızı et, beyaz et, hayvansal bir gıda almıyorum. Sadece balık ve yumurta yiyorum.
Buğday-buğday
(2)
ürünleri, süt ve süt ürünleri, paketlenmiş, kutulanmış hiç bir şey soframızda yer almaz.
Bugün sizlere çok kısık ateşte 47-50 dereceyi geçmeden pişirdiğim Somon balığından bahsedeceğim.
(Avlanma mevsimi hariç yabanıl balık da yemiyorum.)
Asla yapışmaz tabanlı her hangi bir
(3)
Bugün sizlere çok kısık ateşte 47-50 dereceyi geçmeden pişirdiğim Somon balığından bahsedeceğim.
(Avlanma mevsimi hariç yabanıl balık da yemiyorum.)
Asla yapışmaz tabanlı her hangi bir
(3)
"We evolved to be physically active. But most of us avoid physical activity."
The Active Grandparents Hypothesis
Daniel Lieberman, @Harvard
SFI Colloquium, streaming now:
The Active Grandparents Hypothesis
Daniel Lieberman, @Harvard
SFI Colloquium, streaming now:
"We evolved from #apes and apes are couch potatoes."
Daniel Lieberman, @Harvard
SFI Colloquium, streaming now:
#evolution #hominin #anthropology #physiology
Daniel Lieberman, @Harvard
SFI Colloquium, streaming now:
#evolution #hominin #anthropology #physiology
"Your average hunter-gatherer walks from New York to LA every year."
Daniel Lieberman, @Harvard
SFI Colloquium, streaming now:
Daniel Lieberman, @Harvard
SFI Colloquium, streaming now:
🛑Resveratrol konusuna tekrar döneyim.
Resveratrol için #lifespan #longevity uzun yaşam ve sağlıklı hayat dünyasında kirli ilaç, dengesiz ilaç (dirty drug) deyimi kullanılır.
İki formu bulunur.
Trans ve Cis formları.
Bu iki formun arasındaki kimyasal fark ile başınızı şişirmek(1)
Resveratrol için #lifespan #longevity uzun yaşam ve sağlıklı hayat dünyasında kirli ilaç, dengesiz ilaç (dirty drug) deyimi kullanılır.
İki formu bulunur.
Trans ve Cis formları.
Bu iki formun arasındaki kimyasal fark ile başınızı şişirmek(1)
istemem.
Bu yüzden kısaca Trans formunu, yani üzerinde Trans Resveratrol yazanı kullanmanız gerek diyerek işinize yarayan bilgiyi yazayım.
Besin desteği olarak sunulan Trans Resveratrollerin neredeyse hepsi Japon Madımağı (Japanese Knotweed) bitkisinden elde edilir.
Yani (2)
Bu yüzden kısaca Trans formunu, yani üzerinde Trans Resveratrol yazanı kullanmanız gerek diyerek işinize yarayan bilgiyi yazayım.
Besin desteği olarak sunulan Trans Resveratrollerin neredeyse hepsi Japon Madımağı (Japanese Knotweed) bitkisinden elde edilir.
Yani (2)
resveratrol sadece kırmızı üzüm kabuğu veya çekirdeğinde bulunmaz. Ticari olarak daha dengeli ve karlı üretimi japon madımadığından elde edilenidir.
Resveratrol yağda çözünen bir maddedir. Dolayısıyla sadece su ile içmek emilimini azaltır. En iyisi resveratrolü bir miktar (3)
Resveratrol yağda çözünen bir maddedir. Dolayısıyla sadece su ile içmek emilimini azaltır. En iyisi resveratrolü bir miktar (3)
Our latest work is now online @eLife! Studying gene exp. across #mice #lifespan, we show that tissues diverge from each other during #development but tend to converge back during #ageing - potentially losing tissue identity 🧵(1/n)
#aging #bioinformatics
elifesciences.org/articles/68048
#aging #bioinformatics
elifesciences.org/articles/68048
(2/n) Studying gene expression trajectories, we found that developmental trajectories don't necessarily continue into ageing (gene expression trajectories show reversal). but, reversals were not shared across tissues 🤨
(3/n) We, then, hypothesised that reversals may contribute to tissue divergence during development while they are gaining a "tissue identity" but convergence during ageing as they lose their tissue-specific expression signatures 🤔
A combination of alpha-ketoglutarate, a natural supplement used for decades by athletes + vitamins reversed age by an average of 8 YEARS in 7 months.
Fascinating study published on 30 Nov in the Aging Journal.
A thread with all you need to know about the study 👇
Fascinating study published on 30 Nov in the Aging Journal.
A thread with all you need to know about the study 👇
Getting drugs approved for aging is hard and takes time.
Some #longevity experts have started to look at natural supplements to extend #lifespan and #healthspan in the meanwhile.
Some #longevity experts have started to look at natural supplements to extend #lifespan and #healthspan in the meanwhile.
Do these supplements actually work?
The general public and the scientific community is rightfully skeptic.
But #longevity supplements companies are increasingly doing clinical trials and offering biomarker testing to show the compounds they sell, are working.
The general public and the scientific community is rightfully skeptic.
But #longevity supplements companies are increasingly doing clinical trials and offering biomarker testing to show the compounds they sell, are working.
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging
aging-us.com/article/203736…
@AgingJrnl
aging-us.com/article/203736…
@AgingJrnl
Alternatively, you could go with something like this:
Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeast
biorxiv.org/content/10.110…
#aminoacids #lifespan #chonological #age
Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeast
biorxiv.org/content/10.110…
#aminoacids #lifespan #chonological #age
And this:
Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity
researchgate.net/publication/25…
#longevity #age #lifespan
Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity
researchgate.net/publication/25…
#longevity #age #lifespan
"All my friends are dying.",
I realized as I lay on the floor contemplating how to live to 100.
I am dramatic
and obsessed with longevity.
Dramatically obsessed with #healthspan
not #lifespan.
I'm on a quest to live well for a century.
Here's the problem:
🧵
#ship30for30
I realized as I lay on the floor contemplating how to live to 100.
I am dramatic
and obsessed with longevity.
Dramatically obsessed with #healthspan
not #lifespan.
I'm on a quest to live well for a century.
Here's the problem:
🧵
#ship30for30
The problem:
I have no idea what health actually means.
Do we eat meat or not?
Does dairy actually cause cancer?
What about mercury in fish?
Is coffee good or bad?
There's too much conflicting information,
too many buzzwords
and @instagram was making it worse.
#Tweet100
I have no idea what health actually means.
Do we eat meat or not?
Does dairy actually cause cancer?
What about mercury in fish?
Is coffee good or bad?
There's too much conflicting information,
too many buzzwords
and @instagram was making it worse.
#Tweet100
Frustrated, I decided to look at the places where people DID live to 100.
At least I could begin there. These places are called @BlueZones.
Dan Buettner's work studies the world's longest-lived populations and finds best practices.
Turns out, there are only 5 blue zones:
At least I could begin there. These places are called @BlueZones.
Dan Buettner's work studies the world's longest-lived populations and finds best practices.
Turns out, there are only 5 blue zones:
Arlan Richardson showing that JAX-housed mice, like humans, have undergone a dramatic improvement in #lifespan this century ... by reducing deaths from pathogens. #MindYourModels
Recommends looking at lifespan data as the best indicator of husbandry quality at different institutions/sources. Mean survival should be at least 27-30 months.
Example: 2003 Igf1r study showing 33% lifespan extension (in het ♀️s), but mean lifespan of controls was only 19mos. Lifespan effect largely disappeared when replicated in cohorts with longer control lifespan.
This was my go-to question for fly lifespan studies as a postdoc.
This was my go-to question for fly lifespan studies as a postdoc.
I'm often asked how to learn about #AgingBiology, which I hope this thread can address.
Will first list recommended introductory resources, then contextualize and interpret.
There's exciting progress! But also many fanciful ideas, so you can't take everything at face value.
Will first list recommended introductory resources, then contextualize and interpret.
There's exciting progress! But also many fanciful ideas, so you can't take everything at face value.
Will mostly skip the Why/philosophy of #AntiAging, since those asking for resources are likely already bought in.
If interested I wrote a Why/Why not post back in 2016: martinborchjensen.com/hypotheses/agi…, and most of the websites I'll list have a version of this discussion too.
If interested I wrote a Why/Why not post back in 2016: martinborchjensen.com/hypotheses/agi…, and most of the websites I'll list have a version of this discussion too.
The most comprehensive #Aging primer is @ArtirKel's FAQ: nintil.com/longevity.
It does a great job of introducing the field, and distilling the science for non-biologists. Bonus points for contextualizing how biology is different from engineering.
It does a great job of introducing the field, and distilling the science for non-biologists. Bonus points for contextualizing how biology is different from engineering.
1/Short thread on #Longevity
Longevity is a complex challenge, it appears that humans have a rough cap to #lifespan at about 120 years of age (even if you eat healthy, exercise and get lucky with great genes and a great environment).
Longevity is a complex challenge, it appears that humans have a rough cap to #lifespan at about 120 years of age (even if you eat healthy, exercise and get lucky with great genes and a great environment).
3/ There's promising data around #calorierestriction and #MTOR activating molecules like #rapamycin, which in other species can extend #lifespan by 10-15% (which if we're lucky, for the few it might extend the human lifespan cap to 132-138 years of age). discovermagazine.com/mind/the-two-f…
