Discover and read the best of Twitter Threads about #Lymphoma
Most recents (16)
Dear .@gjmccaughan when you wrote this statement were you aware of the #lymphoma risk from mRNA spike-inducing gene therapies, and why were the $100m of dollars of government funding to @StVHealthAust linked to mandatory vaccination not declared?
pubmed.ncbi.nlm.nih.gov/34047035/
pubmed.ncbi.nlm.nih.gov/34047035/
Here is the full statement failing to declare any potential risks of mRNA spike therapy in haematological patients, and including Raina Macintyre and Michelle Anand-Rajah.
It has been archived.
archive.is/nPjca
It has been archived.
archive.is/nPjca
Apart from the oncogenic risk of the mRNA, the AstraZeneca vaccine was known to have killed patients due to VITT yet was still being recommended by the haematologists in that statement, with no warning of the risk in the statement published May 2021.
MALAT1 & NEAT1
Long Non Coding RNAs, Lymphoma and COVID
Interesting paper on new potential biomarkers for aggressive lymphomas, LncRNAs.
It highlights the LncRNAs involved in lymphoma.
There are some similar LncRNAs dysregulated by COVID. >
Long Non Coding RNAs, Lymphoma and COVID
Interesting paper on new potential biomarkers for aggressive lymphomas, LncRNAs.
It highlights the LncRNAs involved in lymphoma.
There are some similar LncRNAs dysregulated by COVID. >
>
>
Another high profile #lymphoma story following mRNA gene therapy vaccines (GTVs).
The problem is that the .@NIH knew about the risk and suppressed it.
@TuffyThePooh another real life victim of Eric Freed and #NIHgate?
The problem is that the .@NIH knew about the risk and suppressed it.
@TuffyThePooh another real life victim of Eric Freed and #NIHgate?
Not the only victim.
The mechanism was known.
#NIHgate is the cover up
theatlantic.com/science/archiv…
The mechanism was known.
#NIHgate is the cover up
theatlantic.com/science/archiv…
You are a young #medicine resident in a busy emergency when a 26/♂️ walks in with 👇🏻
C/o cough and respiratory distress + facial swelling x 7days. He is unable to sleep as the symptoms ⤴️ on lying down 😮
What do you do next?
You read this thread👇🏻
#medtwitter
1/18
C/o cough and respiratory distress + facial swelling x 7days. He is unable to sleep as the symptoms ⤴️ on lying down 😮
What do you do next?
You read this thread👇🏻
#medtwitter
1/18
You immediately know what's going on, you ask for an urgent chest imaging. Only a chest Xray is available and shows 👇🏻
Damnnnnn 😮😮😮
What's that ??
#MedTwitter
2/18
Damnnnnn 😮😮😮
What's that ??
#MedTwitter
2/18
That is a massive mass in the neck and the mediastinum, also B/L CP angles are blunted 😮😮
This looks like a malignancy l/t superior vena cava (SVC) syndrome!
This is a medical emergency and you must know what next to do before the oncologist gets there!
#MedTwitter
3/18
This looks like a malignancy l/t superior vena cava (SVC) syndrome!
This is a medical emergency and you must know what next to do before the oncologist gets there!
#MedTwitter
3/18
1/As promised & after reading $CRSP latest Q4 2022 #financial #report here is my impression regarding @CRISPRTX latest corporate status. I have focused only on the main issues that I found to be the most interesting & relevant. #CRISPR #BioTech #FinTwit #Genomics #GeneEditing 🧵
2/IMO the most significant corporate event in Q4 was $CRSP announcement that regulatory Exa-cel submissions of both #SickleCell & #BetaThalassemia validated in the #EU & #UK & that the @US_FDA BLA submission is on track by the end of Q1 ‘23 - possibly reaching the #markets in ‘23
3/Exa-cel/CTX001 - the key program in $CRSP portfolio, is an #autologous Ex-Vivo #CRISPR/#Cas9 #GeneEditing therapy aimed for patients suffering from #TDT or severe #SCD. The latest readout for both programs was phenomenal with 42/44 TDT & 31/31(!) demonstrated remarkable results
BTK inhibitors have transformed the lives of many patients with Chronic Lymphocytic Leukemia and other lymphomas. These drugs "exploded" onto the scene in 2013-2014 and have fundamentally changed the way we treat the disease. What many people don't know is how it all happened..
In 2004 I became convinced that turning off B-cell receptor signaling would cause cancerous b-cells to stop growing. This theory came into focus based upon an understanding of epstein barr virus protein LMP2A, EBV relationship to Hodgkin lymphoma, and other breadcrumbs
I decided the best way to turn off the receptor would be to use drugs which shut off the signaling pathways emanating from the B cell receptor - notably SYK.
Fortunately Ron Levy M.D. of Stanford was willing to let me test the hypothesis in the laboratory
Fortunately Ron Levy M.D. of Stanford was willing to let me test the hypothesis in the laboratory
CAR T-cells have huge potential for multiple #myeloma.
It's an individualized treatment, complex process, associated with high costs->risk for huge inequality worldwide.
Lets advocate for hope & improvement, together.
🧵on what's new with #ASH22 abstracts
#MedTwitter #mmsm
It's an individualized treatment, complex process, associated with high costs->risk for huge inequality worldwide.
Lets advocate for hope & improvement, together.
🧵on what's new with #ASH22 abstracts
#MedTwitter #mmsm
Mini background of CAR:
-designer proteins that redirect T cells towards a defined surface antigen on tumor cells
-construct contains four essential components
--extracellular antigen recognition
--hinge, spacer
--transmembrane domain
--intracellular signaling domains
-designer proteins that redirect T cells towards a defined surface antigen on tumor cells
-construct contains four essential components
--extracellular antigen recognition
--hinge, spacer
--transmembrane domain
--intracellular signaling domains
1/As promised & after reading $NTLA latest Q1 2022 financial report here is my analysis regarding @intelliatx latest corporate status. I have focused only on the main issues that I found to be the most interesting & relevant. #CRISPR #GeneEditing #BioTech #FinTwit #Genomics👇
2/NTLA-2001 is the most advanced In-Vivo #CRISPR/#Cas9 #GeneEditing program in $NTLA portfolio & is aimed to treat Transthyretin Amyloidosis - (ATTR). NTLA-2001 could potentially halt & reverse the disease in a “one time” treatment by knocking out the TTR gene with a single dose
3/In February $NTLA has presented an updated clinical data from its Phase 1 study of NTLA-2001 which included 15 patients with ATTR amyloidosis. IMO NTLA-2001 readout looks promising & here is a summary that I wrote shortly after @intelliatx’s presentation of NTLA-2001👇
1/10
It is nice when you see a brain #MRI and instantly jump to a unique diagnosis in your mind.
A #tweetorial about #CLIPPERS Chronic Lymphocytic Inflammation with Pontine Perivascular enhancement Responsive to Steroids. #Neurology #NeurologyRF #NeuroRad #MedEd #NeuroTwitter
It is nice when you see a brain #MRI and instantly jump to a unique diagnosis in your mind.
A #tweetorial about #CLIPPERS Chronic Lymphocytic Inflammation with Pontine Perivascular enhancement Responsive to Steroids. #Neurology #NeurologyRF #NeuroRad #MedEd #NeuroTwitter
2/10
CLIPPERS is a #rare #disease being increasingly recognized. We saw a case here @UHhospitals @cwru @CwruNeuro
(The coronal brain MRIs in this tweetorial are from a published case report other than but similar to our patient- I chose to use here instead given better quality)
CLIPPERS is a #rare #disease being increasingly recognized. We saw a case here @UHhospitals @cwru @CwruNeuro
(The coronal brain MRIs in this tweetorial are from a published case report other than but similar to our patient- I chose to use here instead given better quality)
3/10
Middle age patient presenting with emotional liability, subacute bilateral lower extremity weakness/numbness/spasms, ataxia and pan-sphinctric dysfunction over 4 months #NeuroRad
Middle age patient presenting with emotional liability, subacute bilateral lower extremity weakness/numbness/spasms, ataxia and pan-sphinctric dysfunction over 4 months #NeuroRad
I am a dr who has dedicated her career to people w/ #cancer.
I am the grateful daughter of a #lymphoma survivor.
I have #asthma.
Why wouldn't I #wearamask if it might prevent an illness, death, or #longcovid disability?
If you find masks uncomfortable, I can suggest some to try.
I am the grateful daughter of a #lymphoma survivor.
I have #asthma.
Why wouldn't I #wearamask if it might prevent an illness, death, or #longcovid disability?
If you find masks uncomfortable, I can suggest some to try.
(And then I'm going to talk to you for the ENTIRE flight & all the way down the terminal to baggage claim & ground transportation about masks, so be ready if you're in the seat next to me & do this. Might be better just to #WearAMask.😂)
#MedTwitter #TrueStory
#MedTwitter #TrueStory
And then when I change your mind, you'll be in an airplane thumbs-up selfie with me wearing your favorite of the several brands of spare N95 masks I have in my backpack.
"VEXAS SYNDROME", a multidisciplinary team of researchers @genome_gov have identified this new disorder:
(1/8)
➡️Monogenic adult-onset autoinflammatory disease affecting males ♂️👨👦
(1/8)
➡️Monogenic adult-onset autoinflammatory disease affecting males ♂️👨👦
(2/8)
➡️Caused by a mutation in the UBA1 gene 🧬 that encodes major E1 enzyme that initiates ubiquitylation
➡️Suggests postzygotic somatic mutation may be a more frequent cause of human disease👨
➡️Patients develop inflammatory symptoms🔥and hematological abnormalities🩸👇
➡️Caused by a mutation in the UBA1 gene 🧬 that encodes major E1 enzyme that initiates ubiquitylation
➡️Suggests postzygotic somatic mutation may be a more frequent cause of human disease👨
➡️Patients develop inflammatory symptoms🔥and hematological abnormalities🩸👇
(3/8)
🔥🔥INFLAMMATORY SYMPTOMS
👉Fatigue 😫
👉Recurrent fever 🤒🌡️
👉Lung infiltrates 🫁
👉Skin lesions🔴
👉Ear chondritis👂
👉and vasculitis
🔥🔥INFLAMMATORY SYMPTOMS
👉Fatigue 😫
👉Recurrent fever 🤒🌡️
👉Lung infiltrates 🫁
👉Skin lesions🔴
👉Ear chondritis👂
👉and vasculitis
Delighted to share our new study nature.com/articles/s4158… introducing PhasED-Seq out today @NatureBiotech.
A fantastic collaboration from @StanfordMedicine led by Dave_Kurtz & Joanne Soo with @max_diehn to help transform #cancer interception & monitoring by improving #LiquidBiopsy #ctDNA detection of #MRD.
It's #ResearchSpotlight time! Today, we're shining the spotlight on Professor Francesco Forconi...
🔬 Follicular lymphoma and diffuse large B cell lymphoma (DLBCL) are the two most common types of non-Hodgkin #lymphoma.
🔬 Follicular lymphoma and diffuse large B cell lymphoma (DLBCL) are the two most common types of non-Hodgkin #lymphoma.
We can treat this disease, but many treatments have harsh side effects.
💊 Professor Forconi from the University of Southampton wants to find better ways to treat these diseases.
💊 Professor Forconi from the University of Southampton wants to find better ways to treat these diseases.
🏷️ The team are studying ‘tags’ found on the surface of lymphoma cells, which they think tell the immune system to ignore the cancer cells. This means cancerous cells are not destroyed and are allowed to divide and grow in numbers.
Jerome you say below that #cannabis poses more risk for youth than other #FDA approved drugs 👉 Really? More risky than, for example, #Humira - a $20 billion/year immunosuppressive drug, prescribed to children as young as 2? Humira side effects include 👇
2/2 ...Sorry one tweet can’t fit all of Humira’s side effects so continuing here 👇
3/3 Whoops I forgot about death! This one article alone links Humira to 34,000 deaths: google.com/amp/s/amp.json…
Hello new followers!👋 In honor of your joining me on Twitter, I thought I'd put together a new #dermatology #tweetorial/#medthread. This time, on a topic near and dear to my own clinical practice:
MYCOSIS FUNGOIDES!
#MedEd #FOAMEd #Dermtwitter #Medtwitter pc: @dermnetnz
1/
MYCOSIS FUNGOIDES!
#MedEd #FOAMEd #Dermtwitter #Medtwitter pc: @dermnetnz
1/
Let's start w/ caveats:
1-#MycosisFungoides (MF) isn't the same as Cutaneous T-cell Lymphoma. MF is a subtype of #CTCL; there are many other types of CTCL that aren't MF.
2-I co-direct the Skin Lymphoma Program @MGHCancerCenter, so some of this is institutional preference.
2/
1-#MycosisFungoides (MF) isn't the same as Cutaneous T-cell Lymphoma. MF is a subtype of #CTCL; there are many other types of CTCL that aren't MF.
2-I co-direct the Skin Lymphoma Program @MGHCancerCenter, so some of this is institutional preference.
2/
There are roughly 80,000 new cases of #lymphoma a year in the US, and only 3% are primary cutaneous. Within that ~2500 cases, MF makes up almost half (~44%)! The overall classification schema for these diseases was recently updated by the WHO:
bloodjournal.org/content/133/16…
3/
bloodjournal.org/content/133/16…
3/
