Discover and read the best of Twitter Threads about #Lymphopenia
Most recents (4)
My experience: #Covid_19 ICU rotation at #SGPGI #Lucknow
1. All patients were >35 years of age with majority being males
2. Apart from the usual comorbidities, central #obesity without over #diabetes or #hypertension also predisposed to #SARI
1. All patients were >35 years of age with majority being males
2. Apart from the usual comorbidities, central #obesity without over #diabetes or #hypertension also predisposed to #SARI
3. #Lymphopenia was a great marker of severity and a rising trend predicted clinical recovery
4. #recoverytrial further reiterated the use of steroids for patients with severe disease which many centers including ours was already practising
4. #recoverytrial further reiterated the use of steroids for patients with severe disease which many centers including ours was already practising
5. Although initially we had a guarded approach towards it, but #NIV with low pressures worked wonders avoiding intubation
6. Once intubated, outcomes aren’t great. Multiple reasons: severity of disease, nursing care and feeding becomes suboptimal, bradycardia associated with
6. Once intubated, outcomes aren’t great. Multiple reasons: severity of disease, nursing care and feeding becomes suboptimal, bradycardia associated with
1/ #Lymphopenia has recently been under the spotlight with the ongoing COVID-19 pandemic.
This is a quick #Tweetorial attempting to decypher the mechanisms behind lymphopenia, its causes and potential consequences.
What is the most common cause of transient lymphopenia?
This is a quick #Tweetorial attempting to decypher the mechanisms behind lymphopenia, its causes and potential consequences.
What is the most common cause of transient lymphopenia?
2/ Lymphocytes are predominantly T cells (~70%, CD4/8), followed by B cells (~10-20%) and NK cells (~10%).
Normal ALC (absolute lymphocyte count) ranges between 4000 and 10000 cells/microL.
Lymphopenia (or lymphocytopenia) is defined by an ALC of <1000 cells/microL for adults.
Normal ALC (absolute lymphocyte count) ranges between 4000 and 10000 cells/microL.
Lymphopenia (or lymphocytopenia) is defined by an ALC of <1000 cells/microL for adults.
3/ Lymphopoiesis:
- Production in the bone marrow. All lymphocytes arise from a CLP (common lymphoid progenitor).
- Differentiation, selection of T cells in the thymus.
- All lymphocytes (B, T, NK) then continue their maturation in the periphery (lymph nodes, spleen, MALT).
- Production in the bone marrow. All lymphocytes arise from a CLP (common lymphoid progenitor).
- Differentiation, selection of T cells in the thymus.
- All lymphocytes (B, T, NK) then continue their maturation in the periphery (lymph nodes, spleen, MALT).
A hematology @tony_breu-style tweetorial:
Why does lymphopenia occur in #COVID19?
A normal WBC count and lymphopenia are seen in patients affected by COVID-19, but why it occurs has bothered me since the pandemic onset.
The potential answer is surprising and interesting.
Why does lymphopenia occur in #COVID19?
A normal WBC count and lymphopenia are seen in patients affected by COVID-19, but why it occurs has bothered me since the pandemic onset.
The potential answer is surprising and interesting.
First, what do you think the mechanism is?
Does the degree of lymphopenia correlate with survival?
1/
Hi hi hi. We see lots of red flags on a daily basis when we review labs.
One thing we see commonly is #lymphopenia. Should we care? When can we dismiss it and when should we work it up?
Let’s find out.
#MedEd #MedTwitter #IDTwitter #Tweetorial #oncology
Hi hi hi. We see lots of red flags on a daily basis when we review labs.
One thing we see commonly is #lymphopenia. Should we care? When can we dismiss it and when should we work it up?
Let’s find out.
#MedEd #MedTwitter #IDTwitter #Tweetorial #oncology
2/
- Lymphopenia assc w/ ⬆️risk of sepsis
- More common in elderly and w/ co-morbidities
- lymphs account for 20-40% of WBC, may go unnoticed when WBC checked w/o diff
- Primary- recurrent infxns in kids, CVID in adults
- Secondary-⬇️production; ⬆️destruction; hiding in tissue
- Lymphopenia assc w/ ⬆️risk of sepsis
- More common in elderly and w/ co-morbidities
- lymphs account for 20-40% of WBC, may go unnoticed when WBC checked w/o diff
- Primary- recurrent infxns in kids, CVID in adults
- Secondary-⬇️production; ⬆️destruction; hiding in tissue
3/
What is the most common cause of lymphopenia in hospitalized patients?
What is the most common cause of lymphopenia in hospitalized patients?
