Discover and read the best of Twitter Threads about #MAFLD
Most recents (10)
Using data from 4 different cohorts, this one found positive associations between sugar-sweetened beverages & low/no-calorie beverages intake and NAFLD, as assessed using the Fatty Liver Index (FLI) (≥60). 
- The study used data from 42,024 participants from the Lifelines Cohort study (Lifelines; The Netherlands), the Nutrition Questionnaire Plus study (NQPlus; The Netherlands), the PREDIMED-Plus study (PREDIMED-Plus; Spain), and the Alpha Omega Cohort (AOC; The Netherlands).
- Harmonized data analyses of showed positive associations between sugar-sweetened beverages & low/no-calorie beverages intake intakes and FLI-defined NAFLD prevalence.
In this one, adipsin, an adipokine that can stimulate triglyceride synthesis and is involved in the complement system, was found to be associated with MAFLD.
- Individuals with MAFLD had higher levels of adipsin.
- In indivisuals with MAFLD, as the number of metabolic risk abnormalities increased, the levels of serum adipsin and the proportion of moderate to severe fatty liver disease also increased.
The findings of this one support that even plant-based unhealthy dietary choices can be harmful towards metabolic health, as they exhibit a positive association with liver steatosis prevalence.
- The overall plant-based dietary index (PDI), the healthful plant-based dietary index (hPDI) and the unhealthful plant-based dietary index (uPDI) were used to assess one's diet.
- The PDI corresponds to the overall adherence to a plant-based dietary pattern irrespective to the quality of plant-based products consumed.
In this one, muscle fat infiltration was found to be associated with a higher risk of NASH and significant liver fibrosis, regardless of muscle mass, function, or strength, in patients with severe obesity.
- The degree of NASH in liver histology presented as steatosis, and ballooning, and liver fibrosis was correlated with fat infiltration in the muscle assessed, the psoas.
- Psoas muscle fat infiltration was associated with a 2.3-fold increased risk for NASH and a 2.9-fold increased risk for significant liver fibrosis.
This systematic review and meta-analysis suggests that calorie restriction is effective on improving NAFLD markers, and that changing diet composition may have the potential to complement diet-induced weight loss.
- A dose–response association between weight loss and NAFLD surrogate markers was found.
- Meta-regression results suggested that diet-induced improvement in liver stiffness was greatest in the youngest patients and decreased with age.
Interestingly enough, in this one, plasma levels of cis-vaccenic acid, a fatty acid that can be endogenously synthesized through the de novo lipogenesis pathway, was associated with a beneficial cardiovascular risk profile, but with a higher risk for all-cause mortality.
- In this prospective cohort of Dutch adults with normal HDL-c and TG, higher levels of cis-C18:1n7 in plasma phospholipids were positively associated with all-cause mortality.
- In other words, higher DNL activity, reflected by a higher level of cis-C18:1n7, may be related to a higher risk of mortality.
This one tried to investigate the incidence and characteristics of metabolic-associated fatty liver disease (MAFLD) in individuals living in Liaoning Province, China.
- In all subjects, BMI, systolic and diastolic blood pressure, fasting blood sugar, TG, TC, LDL-C, HDL-C, liver enzymes (ALT, AST, GGT, alkaline phosphatase), blood urea nitrogen, serum creatinine, serum uric acid, haematocrit, mean corpuscular volume and urine protein...
...were associated with MAFLD.
Vínculos entre el #SindromeMetabólico y la enfermedad del #HígadoGraso asociada a disfunción metabólica:
Se propone el nuevo término: 'enfermedad del hígado graso asociada a disfunción metabólica' (MAFLD) para reemplazar el término NAFLD
cell.com/trends/endocri…
Se propone el nuevo término: 'enfermedad del hígado graso asociada a disfunción metabólica' (MAFLD) para reemplazar el término NAFLD
cell.com/trends/endocri…
'Enfermedad del hígado graso asociada a disfunción metabólica' (#MAFLD) implica más estrechamente la obesidad y la desregulación metabólica, lo que conduce a una mejor identificación de los pacientes con #EnfermedadHepáticaMetabólica.
La metaflamación, el estrés oxidativo, la disfunción mitocondrial, la sarcopenia y la disbiosis intestinal también están involucradas de manera crítica en la patogénesis de #MAFLD.
MAFLD vs NAFLD: Let the contest begin! onlinelibrary.wiley.com/doi/full/10.11…
Although there are concerns about the name change, it is not going to go away. We all need to become familiar with the debate. Also worth reading the excellent paper in reference 4. #livertwitter #MAFLD #NAFLD
What’s in a name? Please read this excellent piece. (I am one of the authors in this @LiverInt paper #MAFLD #NAFLD #Livertwitter
onlinelibrary.wiley.com/doi/10.1111/li…
onlinelibrary.wiley.com/doi/10.1111/li…
So excited to be one of the authors as I favour the name change. #NAFLD vs #MAFLD
Comments?
@renumathyd @AtoosaRabiee @KapuriaMd @gilbenyakov @jturnesv @drkeithsiau @RashidLui @HyeWonLee20 @JasmohanBajaj @docamitgs @AndrewMMoon @ebtapper @drmoutaz @DrLoomba #livertwitter
Comments?
@renumathyd @AtoosaRabiee @KapuriaMd @gilbenyakov @jturnesv @drkeithsiau @RashidLui @HyeWonLee20 @JasmohanBajaj @docamitgs @AndrewMMoon @ebtapper @drmoutaz @DrLoomba #livertwitter
