Discover and read the best of Twitter Threads about #MBCongress2019

Most recents (8)

I hopped rooms again, for Kiran Krishnan, CSO of Microbiome Labs, with "Intelligent microbiota modulation"
#MBCongress2019
Kiran Krishnan: We can define dysbiosis associated with disease as low amounts of keystone strains. E.g. amounts of Akkermansia, Faecalibacterium, and Bifidobacterium sp. are negatively associated with several health conditions.
#MBCongress2019
Kiran Krishnan: Low amounts of these keystone species: disrupted mucosa, higher immune response, dysfunctional gut barrier, leaky gut.
#MBCongress2019
Read 6 tweets
The next speaker is @KnightsDan with "New methods for affordable and high-resolution shotgun sequencing"
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@KnightsDan Dan Knights: There is a big need for cheap tools (like 16S) that have a high level of information content (like WGS). We started to develop affordable methods of the whole workflow.
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@KnightsDan Dan Knights: How can we automate the lab work? How can we do shallower sequencing to save some money?
See our publication here: msystems.asm.org/content/3/6/e0…
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Read 9 tweets
Christopher Mason @WeillCornell with "Modern methods for deliniating metagenomic complexity: defining clinical quality genome measurements and editing for the microbiome space"
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@WeillCornell Christopher Mason: We work on standardization of 16S and metagenomic analysis: Genome in a bottle (GIAB): extensive, public and un-embargoed data.
Ratios of 16S derived taxa vary a lot with primer choice.
Zymo has a good set of standards to monitor extraction.
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@WeillCornell Christopher Mason: MicrobialStandards.org lists many approaches, and our 2017 paper has suggestions for methods to use:
genomebiology.biomedcentral.com/articles/10.11…
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Read 12 tweets
The second talk of this session will be by Johan van Hylckama Vlieg, @vanHylckama, VP of Microbiome & Human Health Innovation, @Chr_Hansen with "The microbiome as a source of next-generation probiotics and therapeutic microbes"
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@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: I changed my title to "Microbes Matter - More than Ever". I work for @Chr_Hansen, a company in Denmark, the largest producer of live bacterial cultures - for over 140 years!
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@vanHylckama @Chr_Hansen Johan van Hylckama Vlieg: Food cultures and enzymes (mainly dairy cultures), health & nutrition, and therapeutics. We ship trillions of bacteria every day!
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Read 14 tweets
There are three parallel sessions to choose from but I will be live tweeting the talk by Nur Hasan, CSO of @CosmosID with "Unlocking the microbiome with bias-free, affordable, metagenomic sequencing and best-in-class cloud bioinformatics"
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@CosmosID Nur Hasan: The microbiome is broadly implicated with health and disease. Therefore, it is a target for many diagnostic and therapeutic approaches. Interpretation of cause and effect, and understanding pathways all are still not well established.
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@CosmosID Nur Hasan: You need to have high resolution strain-level data for better functional insight. A strain is the clinically informative and actionable unit, not a species.
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Read 10 tweets
I switched to Track 2 but the talk started too early so I missed half of it :-(
Amir Bein - Human intestine chip colonized with complex gut microbiome for in vitro disease modeling and drug testing
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Actually, his talk is already finished. I only saw the last 2 slides. That is too bad - I had hoped to see more of it. :-(
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OK, all of us from the other rooms complained, and Amir Bein is kind enough to give his talk again - Yay!
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Read 14 tweets
Next up is Maxim Daniel Seferovic @MaximSeferovic, Baylor College of Medicine, with "Our earliest microbial encounters and the developmental origins of disease".
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@MaximSeferovic Maxim Seferovic: What are the long term consequences of early exposures to microbes? Genomic variation and epigenomics only partially explain diversity of human phenotypes.
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@MaximSeferovic Maxim Seferovic: Do microbial metagenomes contribute to our phenotypic diversity? Which factors, including maternal factors, determine microbial exposure early in life?
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Read 13 tweets
David Kyle: Breast milk is an important source of nutrition for babies. 85% of the nutrients in milk go into infant growth, 15% of the nutrients are HMO's - this is the food for their microbiome.
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David Kyle: Bifidobacterium infantis is the sole consumer of these HMOs (Human Milk Oligosaccharides). It converts indigestible HMOs into usable fuels: lactate and acetate. These reduce the fecal pH.
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David Kyle: HMO + B. infantis provides pathogen colonization resistance to baby. In those first 100 days, the immune system is educated, so does not work properly. Breastmilk helps protect the baby, it is full of protective factors (IgA etc).
#MBCongress2019
Read 14 tweets

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