Discover and read the best of Twitter Threads about #MIBITOF
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Saved my 1st tweet for my 1st paper and very excited to share what I’ve been working on with @ShirleyGreenba1 and @Inna_Averbukh in @MikeAngeloLab! We assembled the 1st spatio-temporal protein tissue atlas of the human maternal-fetal interface at single-cell resolution 🧵[1/9]
In pregnancy, fetal cells invade the mother’s uterus. They remodel arteries and replace part of the artery lining 🤯 This is an immunological mystery and it’s *required* for healthy pregnancy. Impaired invasion and remodeling are implicated in many pregnancy complications [2/9] 
Which cells participate? How does this evolve with 1) gestational age and 2) artery remodeling? All unanswered Qs. To examine these, we used #MIBITOF to simultaneously profile 37 proteins in archival tissue from 66 patients, analyzing >500k cells and almost 600 arteries [3/9]
