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#MDSideNote: As "outside" #cannabis comes in, a natural counter-balancing occurs. Receptors receiving too much “cannabis signal” reduce in number (turning the signal volume down) BUT: “this reduction of CB1-R[eceptor]s in daily users can be reversed with sustained abstinence.” 
..But when? #MDByte: One study “no longer detected significant reductions in CB1-Receptors after 2-to-4 weeks of cannabis abstinence.” Another study “no longer detected a statistically significant reduction in CB1R availability in cannabis users after 2 or 28 days of abstinence.”
#MDByte: In another study, “the average time of abstinence []was 4 days when the effect of cannabis on CB1R levels was significant. Thus, the reduction in CB1R availability in cannabis users appears to begin to normalize within a period of 2 days to 2 weeks of abstinence.”
