Discover and read the best of Twitter Threads about #MTOR

Most recents (3)

1/Short thread on #Longevity
Longevity is a complex challenge, it appears that humans have a rough cap to #lifespan at about 120 years of age (even if you eat healthy, exercise and get lucky with great genes and a great environment).
2/ So the question is how can we fundamentally move past the 120 year cap? #longevity #lifespan
3/ There's promising data around #calorierestriction and #MTOR activating molecules like #rapamycin, which in other species can extend #lifespan by 10-15% (which if we're lucky, for the few it might extend the human lifespan cap to 132-138 years of age). discovermagazine.com/mind/the-two-f…
Read 7 tweets
1 approach to understanding #covid19 infection is to examine co-morbidities & ask what's common?

Most prevalent Cov19 co-morbs:

1)↗️age
2)Hypertension
3)Diabetes
4)Cardiovascular disease
5)Kidney disease
6)Chronic respiratory disease (esp COPD)
8)Cancers
9)BMI>40
10)♂️>♀️


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2/
These are diverse diseases & increasing age technically not a disease at all. However, there is at least 1 factor in common among all of the co-morbidities identified thus far:

INFLAMMATION
3/
A survey of the co-morbidities revealed another commonality; a close association w/ dysregulation of the pro-inflammatory, neutrophil-recruiting cytokine, IL-17A.

IL-17A is made by multiple immune cell types, including lung-resident innate lymphoid cells (ILC3s).
Read 4 tweets
1/ Continuing the #immunosuppression #tweetorial series...@MedTweetorials

Today's player: #mTORi, mammalian/mechanistic target of rapamcyin inhibitors

Rapamcyin was @US_FDA approved for #kidneytransplant in 2003.

It was isolated from a soil sample from which island in 1975?
2/ Meet mTOR, a phosphatidylinositol 3-kinase (PI3)-related kinase (adds a phos). mTOR adds a phosphoryl group to serine/threonine residues.

It is a key component of the complexes mTORC1 and mTORC 2 - which regulate processes including cell growth, proliferation, and survival.
3/ mTOR inhibition blocks "Signal 3" of #TCell activation - reducing cytokine dependent cell proliferation and activation.

Take a look at all 3 signals below 👇🏽

nejm.org/doi/full/10.10…
Read 11 tweets

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