Discover and read the best of Twitter Threads about #Malignancies

Most recents (2)

@MondayNightIBD 2/📣#IBD & meds carry an⬆️risk of #Malignancies, including lymphomas

🔺Who is at risk?
🔺Is it IBD-mediated or drug-related?
🔺What is our prevention & screening🔎strategy?

Thank you for joining this special #MondayNightIBD #Back2Basics @DuekerJeffrey Image
@MondayNightIBD @DuekerJeffrey @amelia_kellar @DCharabaty @IBD_Afzali @drdani23 @ibddoctor @EdithHoMD @fgomollon @IBD_DrEMF @ibdgijami @MaiaKayalMD 3/ 🔥IBD may carry a unique risk of primary intestinal lymphoma (PILD), but NO🔼risk of extra-intestinal NHL

In CESAME population,
▪️Crude IR of PILD was 0.12/1000 patient-years (py)
▪️All B-cell NH LD
▪️79% ♂️, 11 CD, 3 UC
▪️86% arose in IBD lesions
▪️45% were EBV positive Image
@MondayNightIBD @DuekerJeffrey @amelia_kellar @DCharabaty @IBD_Afzali @drdani23 @ibddoctor @EdithHoMD @fgomollon @IBD_DrEMF @ibdgijami @MaiaKayalMD @JChristieMD @KDeFelice_IBD @dunleavy_katie @IBDMD @MN_GIMD @SaraElOualiMD @nloganmd @KrugCleveland @PDulaiMD @PriSantiagoMD 4/ Lymphoma in #IBD is mostly linked to IBD therapy, particularly #Thiopurines (6MP, AZA)

🔺⬆️Risk in CD, less evidence with UC
🔺M>F
🔺Risk increases with exposure⏲️, particularly >2 years
🔺Risk decrease after cessation of AZA Image
Read 9 tweets
1/
#Cryptococcal Infection in #Hematologic #Malignancies and Hematopoietic Stem Cell Transplantation

Here we review crypto with attention to its background, epi, risk factors, presentations, diagnosis, treatment, & prevention in hematologic malignancies

pubmed.ncbi.nlm.nih.gov/32740974/
2/
At baseline, even prior to the start of immunosuppression, newly diagnosed patients with heme malignancies have cellular & humoral immune deficits with functional and absolute defects in granulocyte and lymphocyte function
that place patients at increased risk for infections
3/
Below is how crypto comes in from the environment. Note the very cool "Trojan horse" mechanism to get into the CNS!
Read 7 tweets

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