Discover and read the best of Twitter Threads about #Met

Most recents (6)

1) Welcome to a new #accredited #tweetorial, "Utilizing Immunohistochemistry Testing, Biomarkers, and Targeted Therapeutics to Optimize Outcomes in Patients with NSCLC," featuring the highlights of a symposium presented at the #ESMOIO22 congress.
@myESMO #LCSM #FOAMed Image
2) The faculty for this outstanding program were @peters_solange (Chair) πŸ‡¨πŸ‡­, @HosseinBorghaei πŸ‡ΊπŸ‡Έ, Natasha Leighl MD πŸ‡¨πŸ‡¦, and @dplanchard πŸ‡«πŸ‡·. A truly international roster of experts in #oncology!
Don't miss prior accredited courses in this space at oncologytweetorials-ce.com/category/lung-….
3) This program is supported by an educational grant from Sanofi. Statement of accreditation and author disclosures are at oncologytweetorials-ce.com/disclosures/.
Read 24 tweets
🚨POLL ALERT!

🎀 Do you think the Sue Gray's report should be published in full?

1) NO. A non-redacted version could harm the ongoing Met investigation

2) YES. The public should know the details no matter what
Just in case you need evidence that the #partygate ever happened, before it gets buried in some dusty shelf at the #Met for the foreseeable future and disappears from memory, we have kept the receipts for you @receiptkeepers

Read 4 tweets
Well imagine having your son killed by them..@garymason479 just needs support ..Brian Harvey knocked her back after he said he was there for her and had a platform to use to be heard..seems bh is either swayed by someone or paid to ignore her and #AmbroseGGBalls PLEA for justice
And the TRUTH
#lorraine @GMB had @sal2nd promoting he's helpful informative book ,he talked about raising he's son and Lorraine bigged up all the work that surrounds this book ..soo NOW TELL ME HOW YOU IGNORE @garymason479 and put the phone down on her call into the studio @reallorraine ?
Read 5 tweets
#OncoAlert Report @JTOonline on PDL1 variability in metastatic #NSCLC. A lot of intriguing information on this increasingly imperfect biomarker. Important to understand what's driving the heterogeneity and how it impacts treatment. @IASLC #LCSM

jto.org/article/S1556-…
#OncoAlert In an analysis of 1398 patients with NSCLC they looked at patterns of PD-L1 expression and the impact of disease site and prior therapy. In a subset who received checkpoint inhibitors, they also looked at outcomes. Could influence how we look at PDL1 IHC. #LCSM
Lesson 1: PD-L1 varies by site. Previously reported. If the biopsy is from liver or adrenal, PDL1 runs higher. Brain and bone, PDL1 tends to be low. Some sets have small numbers but interesting trends and may reflect differences in the immune microenvironment #OncoAlert #LCSM Image
Read 7 tweets
#OncoAlert Important paper now online @CCR_AACR by Dr. Dagogo-Jack @JessicaJLinMD @JustinGainor @MGHThoracicOnc on #MET alterations mediating acquired resistance to #ALK TKI therapy in #NSCLC. Analysis of > 200 post-treatment specimens by FISH/NGS. #LCSM

clincancerres.aacrjournals.org/content/early/…
#MET amplification was seen in 12% of patients post 2nd-gen #ALK TKI and 22% of patients post-lorlatinib. With first line alectinib and brigatinib, MET amplification seems more likely (logical given activity of crizotinib at MET). MET rearrangements also identified! #LCSM Image
As we have several #MET kinase inhibitors (including crizotinib), combinations may overcome resistance (could they prevent it?). In the setting of targeted therapy for #NSCLC, molecular testing at progression increasingly relevant (tissue, plasma - I would favor both). #LCSM
Read 4 tweets
@taylorwestc @nhannahjones Get better soon. πŸ’— I am curious about specifically mortgage/derivatives/stocks & bonds markets using Black & Brown/immigrant human capital to enrich investors. I know @BillGates invests in @GEOGroup.... more in thread.
@taylorwestc @nhannahjones @BillGates @GEOGroup @BillGates brought us #CommonCore and with it all the increases in standards+high stakes testing. #PARCC & #SBA are based on standardized testing created for Eugenics, promoted by former philanthrocapitalists. This alone directly adds BIPoC youth to the school to prison pipeline.
@taylorwestc @nhannahjones @BillGates @GEOGroup @BillGates also brought the #MET teacher evaluation project, forcing schools & states to focus on teachers evals as high stakes also. Educators & schools spent tons of time & $ teaching TO the racist TEST, eliminating arts, music, sports, feeding the S2PrisonPipeline again.
Read 8 tweets

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