Discover and read the best of Twitter Threads about #Metformin
Most recents (24)
#Metformin RCT on 41% prevention of #LongCOVID with acute #COVID19 treatment is now published in @TheLancetInfDis at:
doi.org/10.1016/S1473-…
N=1126 with long term follow up (~5% lost by 9mo)
10.4% vs. 6.3% LC incidence.
Double blind RCT using identical matched placebo.
Cost $1
doi.org/10.1016/S1473-…
N=1126 with long term follow up (~5% lost by 9mo)
10.4% vs. 6.3% LC incidence.
Double blind RCT using identical matched placebo.
Cost $1
The distribution of symptoms reported over time was similar as others have found. The figure (a new additional from the original pre-print) displays the freq of symptoms reported over 9 months among those wih a long covid diagnosis vs. no diagnosis.
#LongCovid symptoms interfered with both the ability to work and affected leisure activities in about half of those with LC. This very, very slowly decreased over time.
Phase-3-Studie: #Metformin führt zu 42% Verringerung der Notaufnahmebesuche/Krankenhausaufenthalte/Todesfälle nach 14 Tagen, zu 58% Verringerung der Krankenhausaufenthalte/Todesfälle nach 28 Tagen und zu 42% Verringerung von #LongCovid nach 10 Monaten.
#COVID19 #Coronavirus
#COVID19 #Coronavirus
Die mittlere #SARSCoV2-Viruslast wurde mit Metformin im Vergleich zu Placebo um das 3,6-fache reduziert, während es keinen virologischen Effekt für Ivermectin oder Fluvoxamin gegenüber Placebo gab.
medrxiv.org/content/10.110…
#LongCovid #COVID19 #Corona #Metformin
medrxiv.org/content/10.110…
#LongCovid #COVID19 #Corona #Metformin
Eine neue Studie zeigt drei verschiedene Möglichkeiten auf, wie #Metformin gegen #SARSCoV2 wirken könnte
Metformin, ein Antidiabetikum,
➡️ blockiert die Bindung der SARS-CoV-2-Spike-Protein-Rezeptorbindungsdomäne RBD an den menschlichen ACE2-Rezeptor…🧵
#COVID19 #Coronavirus
Metformin, ein Antidiabetikum,
➡️ blockiert die Bindung der SARS-CoV-2-Spike-Protein-Rezeptorbindungsdomäne RBD an den menschlichen ACE2-Rezeptor…🧵
#COVID19 #Coronavirus
➡️ hat entzündungshemmende Wirkungen; es hemmt die Sekretion von IL1b, einem wichtigen Zytokin im "Zytokinsturm" bei COVID-19, und reduziert die Zytokinsekretion
➡️ hemmt die Ansammlung entzündlicher Monozyten an Endothelzellen.
Metformin in nasaler Darreichungsform wurde
➡️ hemmt die Ansammlung entzündlicher Monozyten an Endothelzellen.
Metformin in nasaler Darreichungsform wurde
bisher noch nie getestet, daher wurde hier dieser Weg gewählt.
Während die entzündungshemmende und infektionshemmende Wirkung von Metformin eindeutig nachgewiesen werden konnte, war seine Fähigkeit, die Viruslast in der Lunge des Hamstermodells zu reduzieren, im Vergleich zu
Während die entzündungshemmende und infektionshemmende Wirkung von Metformin eindeutig nachgewiesen werden konnte, war seine Fähigkeit, die Viruslast in der Lunge des Hamstermodells zu reduzieren, im Vergleich zu
Another confirmatory trial of beneficial effect of #fluvoxamine 100mg BID with Budesonide inhaler in a highly vaccinated population for #COVID19
Dose matters. 50mg 2x/d is not 100mg 2x/d. FLV 50mg 2x/d did not have benefit in two trials
Dose matters. 50mg 2x/d is not 100mg 2x/d. FLV 50mg 2x/d did not have benefit in two trials
As a combo blinded trial (FLV + inhaler), which one had benefit? Hard to know. In activ-6, we did not observe a benefit of inhaled fluticasone in a double blind RCT, yet UK Principle did see a benefit in open label trial with budesonide.
Importantly the #fluvoxamine dose studied here was 100mg 2x/day.
Covid-out and activ-6 both confirmed a lack of benefit of 50mg 2x/day dose.
If I gave someone 1/2 the effective dose of an HIV med & it didn't work, does that mean the med doesn't work? Or just dose was wrong?
Covid-out and activ-6 both confirmed a lack of benefit of 50mg 2x/day dose.
If I gave someone 1/2 the effective dose of an HIV med & it didn't work, does that mean the med doesn't work? Or just dose was wrong?
#Paxlovid effect on reducing #COVID19 hospitalizations in vaccinated population finally revealed to the public by FDA. #IDTwitter
0.9% (3/317) paxlovid vs. 2.2% (7/314) placebo
fda.gov/media/166197/d…
0.9% (3/317) paxlovid vs. 2.2% (7/314) placebo
fda.gov/media/166197/d…
The relative risk reduction (RRR) of #covid19-related hospitalization was 57.5% (95%CI, -63% to 89%) with #Paxlovid in vaccinated high risk population.
Will point out that the the Hazard Ratio is also 58% for $1 of #metformin.
Will point out that the the Hazard Ratio is also 58% for $1 of #metformin.
#covid19 : nouveau point de situation personnel, mais sourcé d'@EricTopol
Pour lui
🔹passage en phase #endémique malgré le risque toujours présent et estimé < 30 % de survenue dans les 2 ans de l'émergence d'un variant + dangereux et/ou plus contagieux.
1/
Pour lui
🔹passage en phase #endémique malgré le risque toujours présent et estimé < 30 % de survenue dans les 2 ans de l'émergence d'un variant + dangereux et/ou plus contagieux.
1/
Le schéma ⤵️ résume les 4 facteurs qui mènent à l'émergence de nouveaux variants (pers. immuno-compromises chez qui le virus évolue ; absence de mesures de prévention au niveau mondial pour contenir les contaminations ; réservoirs animaux avec les pblématiques de co-infection
2/
2/
🔹des espoirs concernant la prévention du #covidlong suite à la publication de la récente étude randomisée sur le bénéfice de la prise de #metformin pendant 15 jours (même si un essai randomisé en double aveugle avec #Paxlovid et #metformin est souhaitable).
🔹toujours rien
3/
🔹toujours rien
3/
Microcytic anemias, which affect all cell lines, can have adverse effects on brain and nervous system health. Iron deficiency #anemia, the most common type of microcytic anemia, can cause #cognitive impairment. 🧵(1/18)
Iron is crucial for #brain function, and its #deficiency can reduce #oxygen delivery to the brain, affecting #cognitive processes like #attention, #memory, and learning. (2/18)
#B12 deficiency, another common cause of microcytic anemia, can also damage the nervous system. (3/18)
Does #metformin reduce hospitalization or not? In a double-blind placebo controlled trial, 28-day data:
NIH guidelines cite the 14-day mITT data where there was not a statistical reduction.
The 14-day and 28-day ITT data also had a statistical reduction in hospitalization.
NIH guidelines cite the 14-day mITT data where there was not a statistical reduction.
The 14-day and 28-day ITT data also had a statistical reduction in hospitalization.
These numerical complete case data were published in NEJM.
"Through day 28, hospitalization or death occurred in 8 of 596 patients (1.3%) receiving metformin and in 19 of 601 controls (3.2%)"
(2.9% & 1.2% above are by Kaplan-Meier methodology).
nejm.org/doi/full/10.10…
"Through day 28, hospitalization or death occurred in 8 of 596 patients (1.3%) receiving metformin and in 19 of 601 controls (3.2%)"
(2.9% & 1.2% above are by Kaplan-Meier methodology).
nejm.org/doi/full/10.10…
While the authors were not allowed to highlight these data or put a p-value in, apparently there are a lot of poeple who can't run a chi-square or fisher's exact test -- as I keep hearing that metformin didn't reduce hospitalization in the COVID-Out trial.
1) Welcome to our #accredited #tweetorial on clinical trial results and emerging data for treatment of Diabetes and CKD #DM in #CKD. I am Brian Rifkin MD, @brian_rifkin, from the Hattiesburg Clinic. #Nephtwitter #Medtwitter #FOAMed
2) This #accredited #tweetorial series on #kidneydisease #CKD is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance. It is not intended for US- or UK-based HCPs. Accreditation statement & faculty disclosures at ckd-ce.com/disclosures/.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Prior programs in this series, still eligible for CE/#CME, can be accessed at ckd-ce.com. FOLLOW US to learn from expert faculty!
1/🧵Can a Diabetes drug prevent Long COVID?
Most solid data yet of a medication preventing #LongCOVID from quadruple blinded, non-pharma sponsored COVID-OUT trial N=1,125.
A 42% relative ⬇️ in clinician diagnosed LC was seen (10.6% down to 6.3%).
bit.ly/3jvvKj4
Most solid data yet of a medication preventing #LongCOVID from quadruple blinded, non-pharma sponsored COVID-OUT trial N=1,125.
A 42% relative ⬇️ in clinician diagnosed LC was seen (10.6% down to 6.3%).
bit.ly/3jvvKj4
2/ Metformin’s success (1 LC prevented for every 23 pts treated) could save millions from suffering.
<$1 per course = very cost effective.
Too good to be true? Maybe but very solid science.
Let me unpack a bit more…
bit.ly/3jvvKj4
<$1 per course = very cost effective.
Too good to be true? Maybe but very solid science.
Let me unpack a bit more…
bit.ly/3jvvKj4
3/ This trial had 6 groups of patients because 3 meds (metformin/fluvoxamine/ivermectin) were randomized vs. placebo.
The other drugs showed no benefit toward Long COVID reduction.
Metformin also looked good for Acute COVID.
The other drugs showed no benefit toward Long COVID reduction.
Metformin also looked good for Acute COVID.
COVID-Out double-blind randomized trial tested #metformin, ivermectin, or fluvoxamine for outpatient #COVID19. Secondary endpoint was incidence of Long Covid (PASC).
Volunteers were followed monthly to 10 mo.
Metformin 42% reduction in Long Covid.
medrxiv.org/content/10.110…
Volunteers were followed monthly to 10 mo.
Metformin 42% reduction in Long Covid.
medrxiv.org/content/10.110…
Incidence of Healthcare provider diagnosed long covid (PASC) was 42% less among those randomized to #metformin vs. matched placebo.
Hazard Ratio for Long Covid in the metformin group versus control was 0.58 (95% CI 0.38 to 0.88, P=0.009);
Hazard Ratio for Long Covid in the metformin group versus control was 0.58 (95% CI 0.38 to 0.88, P=0.009);
There was no benefit for those randomized to #ivermectin vs. matched placebo for reducing long covid and low-dose #fluvoxamine was not beneficial either for decreasing #longcovid.
1) Welcome to a new #accredited (0.75h CE/#CME) #tweetorial on challenging case presentations for pts with #cardiometabolic disease, #CaReMe #FOAMed.
Our expert author is Claire Davies. @claireyrivs is a specialist diabetes & endocrinology #pharmacist working in Gateshead in 🇬🇧.
Our expert author is Claire Davies. @claireyrivs is a specialist diabetes & endocrinology #pharmacist working in Gateshead in 🇬🇧.
2) She is a member of UKCPA Diabetes & Endocrinology committee @UKCPADiabetes & works across #diabetes, #endocrinology, & emergency/acute care in Secondary Care. She is currently involved in development of regional guidelines & education to support medicines optimisation for PLWD
3a) This program is intended for healthcare professionals and is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company.
1) Welcome to our new #accredited #tweetorial which is Part 1 of a 2-part "highlights" program on new #SGLT2i & #DKD data presented at @ERAkidney #ERA22. #Physicians #nurses #pharmacists #PAs and #NPs can all earn 0.5h CE/#CME by following this thread!
2) @ERAkidney #ERA22 is a primary international scientific symposium for interaction and exchange among basic scientists and clinicians working in #Nephrology. It was held in May. Our expert author is Dr. Sheila Bermejo (@shbermejo) from @vallhebron in Barcelona, Spain.
3) This program is #accredited for CE/#CME & is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance. It is not intended for US- or UK-based based HCPs. Accreditation statement & faculty disclosures at ckd-ce.com/disclosures/.
1) Welcome to an #accredited #tweetorial on optimizing the use of #SGLT2i in the management of #T2D. This program is accredited for 0.50 🆓credits for #physicians #nurses #physicianassociates #nursepratcitioners #pharmacists by @academiccme! I am @tmodarressi of @HeartDoctorNJ.
@AndrewJSauer @DrMichaelShapir @MichaelJBlaha @dramitkhera @pnatarajanmd @PamTaubMD @DrMarthaGulati @DrRaniKhatib @AAgarwalaMD @RpratleyMD @drricardocorrea @AliceYYCheng @SantosGallegoMD @SABOURETCardio @hvanspall @DLBHATTMD @cpcannon
2) This program is intended for healthcare professionals and is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company. See archived programs, all by expert authors, still available for credit at cardiometabolic-ce.com.
1) Welcome to our new #tweetorial on optimizing #interprofessional & #multidisciplinary care & medical therapy for patients with #DKD. I am Sophia Ambruso DO, @Sophia_kidney, from @CU_kidney.
2) This #accredited #tweetorial series on #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers. Faculty disclosures are at ckd-ce.com/disclosures/.
3) This activity is accredited for 0.75h credit for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. FOLLOW US for more programs by expert faculty!
1) Welcome to our new #accredited #tweetorial on #mechanismofaction & impact of meds commonly used in patients with or at risk for #DKD progression: #MRAs, #GLP-1 receptor agonists & #DPP-4 inhibitors. I am Sophia Ambruso DO, @sophia_kidney, from @CU_Kidney.
2) This #accredited #tweetorial series on #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
Delighted to see my paper “The Economic Value of Targeting Aging” -written with @NuCampEconomics and @davidasinclair – published in @NatureAging nature.com/articles/s4358…
Here is a thread explaining the main results-
#aging #longevity 1/12
Here is a thread explaining the main results-
#aging #longevity 1/12
Life expectancy has increased dramatically over last 150 years - most US children born today are expected to live into their mid-80s #longevity. This has shifted the disease burden towards chronic Non-Communicable diseases #aging and an increase in years spent in poor health 2/12
How should we value these past and future life expectancy gains? Is a compression of morbidity more valuable? What is the value of treatments that delay #aging? How does that compare with treating single diseases? 3/12
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
1/12 👩🏼🔬 Nieuw onderzoek (preprint): "#Metformin use is associated with reduced mortality in a diverse population with COVID-19 and diabetes"
Is dit dan 'n middel tegen COVID-19? Het mag goed klinken maar ik denk 't niet 👇🏻
(CW ziekteangst, ongelijkheid)
medrxiv.org/content/10.110…
Is dit dan 'n middel tegen COVID-19? Het mag goed klinken maar ik denk 't niet 👇🏻
(CW ziekteangst, ongelijkheid)
medrxiv.org/content/10.110…
2/12 Achtergrond: type 2 diabetes mellitus (T2DM) is een vorm van suikerziekte waarbij het lichaam niet meer goed op insuline reageert (insulineresistentie).
Dit in tegenstelling tot type 1 (T1DM) waarbij het lichaam wel goed op insuline reageert maar het niet meer zelf maakt.
Dit in tegenstelling tot type 1 (T1DM) waarbij het lichaam wel goed op insuline reageert maar het niet meer zelf maakt.
3/12 Om schadelijke gevolgen van een hoge bloedsuikerspiegel bij T2DM te voorkomen krijgen mensen medicatie om deze te verlagen. Metformine wordt veel gebruikt.
Het is een bijzonder middel: we weten niet zo heel goed hoe 't werkt.
Daarover later meer; eerst naar 't onderzoek.
Het is een bijzonder middel: we weten niet zo heel goed hoe 't werkt.
Daarover later meer; eerst naar 't onderzoek.
(1/) An update of analysis of Dr. Raoult’s #hydroxychloroquine #azithromycin trial on 1061 patients.
mediterranee-infection.com/pre-prints-ihu/
(warning: it’ more like conspiracy theory)
mediterranee-infection.com/pre-prints-ihu/
(warning: it’ more like conspiracy theory)
(2/) Actually the preprints have two versions.
“Version 2”
mediterranee-infection.com/wp-content/upl…
Final version
mediterranee-infection.com/wp-content/upl…
There're minor changes in the final version compared to v2. Most are Ct values and HCQ serum concentrations. Other baseline characteristics are the same.
“Version 2”
mediterranee-infection.com/wp-content/upl…
Final version
mediterranee-infection.com/wp-content/upl…
There're minor changes in the final version compared to v2. Most are Ct values and HCQ serum concentrations. Other baseline characteristics are the same.
(3/) Another difference is the way that NEWS scores were presented.
Version 2. Mean-Sd-median-range.
Final version. Low-medium-high brackets.
Version 2. Mean-Sd-median-range.
Final version. Low-medium-high brackets.
Insulin is NOT a first choice medicine in type 2 diabetes mellitus (T2DM).
Exceptions:
- Short-term use in #T2DM:
(1) ketosis
(2) sepsis
(3) extremely high blood glucose
- Long-term use in #T2DM:
(4) secondary oral medication failure (also called ß-cell failure)
@sambit_dash
1.
Exceptions:
- Short-term use in #T2DM:
(1) ketosis
(2) sepsis
(3) extremely high blood glucose
- Long-term use in #T2DM:
(4) secondary oral medication failure (also called ß-cell failure)
@sambit_dash
1.
The guideline chart attached above is very clear - lifestyle modifications should be the first choice ± #metformin. Metformin is cheap.
I am least influenced by industry, and use long-term insulin in <5% T2DM, mostly for reason (4), usually after exhausting other options.
2.
I am least influenced by industry, and use long-term insulin in <5% T2DM, mostly for reason (4), usually after exhausting other options.
2.
Those <5% are at a secondary level care hospital, and not at primary care. In primary care, that number will be even lower.
For those who NEED, both biphasic insulin and glargine are available in @pmbjpbppi #JanAushadhi kendras too. Insulin is quite inexpensive there.
3.
For those who NEED, both biphasic insulin and glargine are available in @pmbjpbppi #JanAushadhi kendras too. Insulin is quite inexpensive there.
3.
