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1) A brief review of paracetamol aka PCM
Synthesized by HN Morse at John Hopkins at 1977 --> a derivative of acetanilide and phenacetin.
It has become a common household drug since the 1980s as phenacetin use dropped --> concerns of analgesic nephropathy.
Synthesized by HN Morse at John Hopkins at 1977 --> a derivative of acetanilide and phenacetin.
It has become a common household drug since the 1980s as phenacetin use dropped --> concerns of analgesic nephropathy.
2) It is best known as acetaminophen aka Tylenol in the Western hemisphere.
PCM provides good antipyresis and analgesia --> but anti inflammatory action is minimal.
PCM provides good antipyresis and analgesia --> but anti inflammatory action is minimal.
3) PCM is basically an NSAID that blocks COX1 and COX2 enzymes --> at the peroxide site (distinct among NSAID).
But inflammation raises local peroxide levels --> counters PCM action.
So PCM is a great antipyretic and analgesic but poor anti inflammatory.
But inflammation raises local peroxide levels --> counters PCM action.
So PCM is a great antipyretic and analgesic but poor anti inflammatory.
