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Arlan Richardson showing that JAX-housed mice, like humans, have undergone a dramatic improvement in #lifespan this century ... by reducing deaths from pathogens. #MindYourModels
Recommends looking at lifespan data as the best indicator of husbandry quality at different institutions/sources. Mean survival should be at least 27-30 months.
Example: 2003 Igf1r study showing 33% lifespan extension (in het ♀️s), but mean lifespan of controls was only 19mos. Lifespan effect largely disappeared when replicated in cohorts with longer control lifespan.
This was my go-to question for fly lifespan studies as a postdoc.
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