Discover and read the best of Twitter Threads about #MuVariant
Most recents (6)
📌VARIANT update on #MuVariant vs #DeltaVariant— it seems Ecuador #SARSCoV2 sequencing shows Mu variant competing well versus the Delta variant—both displacing all others. Lambda and Iota almost extinct. ➡️#MuVariant hanging on & expanding next to Delta.🧵
nextstrain.org/ncov/gisaid/so…
nextstrain.org/ncov/gisaid/so…
2) That said, in Colombia, where #MuVariant first emerged & once dominant, #DeltaVariant is outpacing Mu. Interesting Ecuador they are more or less tied, but in Columbia Delta is winning. Maybe because immunity against Mu has been building longer in Colombia—while Delta is new.
3) What about #MuVariant vs #DeltaVariant in the US? It seems Delta is harder to control than Mu. Mu seems to rank second in R(t) — the R at current time — behind Delta. This is I guess good. But as Delta goes away, and we lift restrictions- will R(t) of Mu stay under 1? Dunno.
“The #DeltaVariant will not be the last variant of concern (VOC)”, says @WHO’s @mvankerkhove, who warns “The #MuVariant, there are others that are circulating. The surge of not only preparing vaccination, but improving our surveillance systems, getting tests out there”… 🧵
2) “make sure we manage mass gatherings, or postpone them 👀, make sure we fix ventilation in our buildings…” - thank you @mvankerkhove
3) Here is the latest info on the #MuVariant for those interested. I give a more nuanced assessment of it. It could be bad but could be less aggressive than #DeltaVariant, which is still the heavyweight dominant champion variant worldwide currently. See thread 🧵 below ⬇️
📍Bad news on #MuVariant—Japanese scientists: "Mu variant is highly resistant to sera from convalescent & [Pfizer]-vaccinated people. Direct comparison of different spike proteins revealed that Mu spike is more resistant…than all other current variants”🧵
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
2) The #MuVariant started in Colombia 🇨🇴, but is already worldwide, including in US and UK. In Colombia, how fast did it dominate? Pretty fast. But #DeltaVariant is catch up with it too.
3) Where is it in UK? Popped up everywhere despite Delta domination. Hmm. the-sun.com/health/3614819…
📍The @WHO is monitoring a new coronavirus variant called "mu." It has mutations that have the “potential to evade immunity” by a previous infection or vaccination, the WHO said. #MuVariant was first identified in Colombia & now in at least 39 countries 🧵
google.com/amp/s/www.cnbc…
google.com/amp/s/www.cnbc…
2) The new #MuVariant is also known as #B1621 and is currently a new “variant of interest”, but not yet a VOC. who.int/en/activities/…
3) “The variant contains genetic mutations that indicate natural immunity, current vaccines or monoclonal antibody treatments may not work as well against it as they do against the original ancestral virus, the WHO said.”
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
