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#MyFirstChemSci 🙌🏼
Are you an antibiotic targeting RNA-P? You just got an upgrade! We used the microbial iron transport machinery to enhance potency and improve accumulation into bacteria, where cleavable linkers release.
tinyurl.com/3chw8pnt @ChemicalScience
A 🧵: (1|n)
Are you an antibiotic targeting RNA-P? You just got an upgrade! We used the microbial iron transport machinery to enhance potency and improve accumulation into bacteria, where cleavable linkers release.
tinyurl.com/3chw8pnt @ChemicalScience
A 🧵: (1|n)
We found a way to enhance the potency of antibiotics targeting RNAP, rifamycins but also Corallopyronin A & Sorangicin A, by exploiting microbial iron transport to improve drug translocation across bacterial membranes using bacterial iron chelators- #siderophores. (2|n)
Gram-negative bacteria pose a unique challenge, due to their double membrane structure for antibiotic uptake e.g. for RNA-P inhibitors needing to reach the cytosol. But with innovative, targets approaches we can enhance their antimicrobial activity and overcome this hurdle. (3|n)
