Discover and read the best of Twitter Threads about #N440K
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Have we reached to the peak of 2nd #Covid wave in India? May be, yes! Its already 2.5 months in to it. Most badly affected countries peaked within 1.5-3 months of onset of a new surge. Is it too early to comment? 1/ 
More interesting would be to see which way our curve goes: the UK/Israel or the US way! While both UK/Israel took 1.5-2 months to flatten their curves w/ strict lockdowns & aggressive vaccination, US had a long plateau (>3.5 months) 2/
However, there is heterogeneity in caseloads: While states like MH, UP, CG, PB, DL are showing ⬇️ in case load, some southern & eastern states (KA, KL, AP, TN, WB, ) still reporting cases in high numbers! What is driving Covid in these states? 3/ indiatoday.in/coronavirus-ou…
Okay, so there has been a lot of news circulating about N440K variant being or not being the cause of second wave based on a study from our lab...I will just try to clarify the findings which have been discussed and how the findings were interpreted: a thread
#N440K #LongCovid
#N440K #LongCovid
So a few days back we published a preprint from our lab that N440K variant (also known as B.1.36) has more infectious fitness than its parent lineage A2a ( also known as D614G mutant or B.1.1.8) and an unrelated A3i variant (aka B.6)
We have also suggested that based on the sequence information on @GISAID till April 24th 2021, the proportion of N440K variants are increasing, clustering in some regions more than the others.
Lineages with #N440K are NOT the dominant ones in the second wave of #Covid19inIndia. While N440K was a indeed mutation of concern in South India during and after the first wave, current data shows that it is essentially replaced by new VoCs such as #B1617 and #B117
When comparing the data from MH, in MH we can see that the increase in B.1.617 is seen in Feb rather than Mar 2021, and again we observe a reduction in proportion of lineages with N440K.
This coincides well with the second waves seen in the respective states. In MH, the second wave started almost a month and half earlier compared to the 4 southern states, along with the explosion of B.1.617 at the expense of lineages with the mutation N440K.
