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Some thoughts on the Nooma Bio insights from @new299 's substack blogpost:
I saw this picture and it reminded me a lot of another similar schematic, which is for photolithography of semiconductor chips (right-hand picture)
I saw this picture and it reminded me a lot of another similar schematic, which is for photolithography of semiconductor chips (right-hand picture)
The whole point of the more complicated setup in the Nooma Bio approach is that, by having 3 electrodes and two pores, one can control the flow better. But also, read the same single molecule more than once in the same pore pair. Nava puts it clearly here:
Further down, it seems there would be a limit to how fast/slow the molecules go through the pore, which would make it difficult to reach DNA base resolution (even worse for #NGPS protein sequencing)
