Discover and read the best of Twitter Threads about #NOD2
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🚨🚨I'm proud to present our lab's first peer-reviewed paper, out at @cellhostmicrobe🥳. We started out by asking a basic question about mucus secretion, and discovered something surprising about genetic risk to inflammatory bowel diseases (#IBD). A🧵/1
cell.com/cell-host-micr…
cell.com/cell-host-micr…
Every cell that secretes something needs to have some kind of control over how much it secretes. We asked how goblet cells in the intestine "know" how much mucus they need to secrete. I wrote about it here when we published our #preprint 👇🏻. /2
We found that ER stress is the cell-intrinsic switch that tells the goblet cell when to stop producing mucus, and that autophagy is tasked with relieving this stress to allow secretion. /3
