Discover and read the best of Twitter Threads about #NR
Most recents (6)
When you take a set of say 6 rules you respect and internalise.
You suddenly become very aware when you violate the boundaries.
You suddenly become very aware when you violate the boundaries.
This idea is dangerous because authorship can be erased without consequence.
The rules just need to give you a clear relatable model of understanding the world.
Soon, they become second nature.
The rules just need to give you a clear relatable model of understanding the world.
Soon, they become second nature.
These few rules are like a boundary wall against the errors of human nature.
The picture here is that of keeping snakes outside that boundary.
It is true that which says, "And whoever breaks through a wall will be bitten by a serpent."
The picture here is that of keeping snakes outside that boundary.
It is true that which says, "And whoever breaks through a wall will be bitten by a serpent."
"Jugar con las apariencias y dominar el arte del engaño es uno de los placeres estéticos de la vida."
#nr #juststarted #48leyesdelpoder #robertgreene
#nr #juststarted #48leyesdelpoder #robertgreene
"Cualquier hombre que intente ser bueno todo el tiempo terminará yendo a la ruina entre la gran cantidad de hombres que no lo son. (Quién) quiera conservar su autoridad deberá aprender a no ser bueno y usar ese conocimiento, o prescindir de su uso, según las necesidades."
every week, i get an email from a desperate parent whose kid has a potentially incurable cancer, asking if they should take #NR, often in a cocktail with resveratrol & other stuff /1
experiences like these make me shudder at the 💩 being peddled in the name of "anti-aging." no phd scientist should tell any such parent that their kid's rare malignancy is curable with their favorite elixir /2
i remind ppl that NR is active in many rodent models of human diseases & conditions of metabolic stress in which the NAD system is under attack (heart failure, fatty liver, neurodegeneration, central brain injury, etc) /3
@HeerCollin @FehrLab @MichaelNADbio & I just published biorxiv.org/content/10.110…. This is our 1st of several works on #SARSCoV2. We show that the virus upsets the NAD system in powerful & potentially actionable ways /1
Some years ago when @FehrLab was with Stanley Perlman @uiowa, they discovered that coronaviruses encode a gene that takes ADPribose off of proteins & use this gene to be highly infective. They also showed that the virus turns on expression of several PARP genes /2
With my former student, Sam Trammell, we obtained data showing that coronaviruses upset cellular NAD. This is important because our cells need NAD coenzymes to run everything including our defense against viruses--the virus also hijacks our metabolism to make more virus /3
So grateful to @TheFangGroupUiO and impressed with @NoAge100. Months ago, I told Evandro that @HorizonsHK invited me to beautiful #Norway. He responded with a request to keynote noage100.com/2019/08/17/nad… 
At this conf, there were presentations on clinical testing of #nicotinamideriboside in #ataxiatelangiectasia, #Parkinsonsdisease, #frailty, #chemotherapyinducedcardiomyopathy & #amyotrophiclateralsclerosis, all premised on sound preclinical data and all based in beautiful Norway
Beyond that, they have strong interest/plans in #alcoholicliverdisease, #mildcognitiveimpairment & more. So impressed with the scientists, physicians & institutions in Norway that make this possible @Ahus_no @oslouniversity @ChromaDex #NR #NAD #Bergen #Tromsø #thebestisyettocome
Did you know that NAD, NMN and NR were described in the 1940s as factor V, an essential growth factor to grow Haemophilus influenza? H influenza is a flu-causing bacterium that only a few microbiologists ever wanted to grow. NR worked better than NMN and NAD because /1
Phosphorylated compounds can't get into cells. H influenza needs NR because it doesn't have the genes to make NAD from amino acids, nicotinamide or nicotinic acid. There was no market for NR because who wants to grow H influenza? /2
In 2004, I was working on glutamine-dependent NAD synthetase in yeast. This enzyme performs the final step in making NAD from tryptophan, nicotinamide and nicotinic acid (all the then-known NAD precursors in eukaryotic cells). /3
