Discover and read the best of Twitter Threads about #NSEvac
Most recents (6)
Our group has examined 💉s for their effects on all-cause outcomes and a clear pattern has emerged:
Live 💉have beneficial non-specific effects on all-cause mortality
The non-live 💉we have examined have had negative effects.
Many therefore asked us about COVID vaccines
🧵
Live 💉have beneficial non-specific effects on all-cause mortality
The non-live 💉we have examined have had negative effects.
Many therefore asked us about COVID vaccines
🧵
Our current system for testing and approving vaccines does not take effects on all-cause outcomes, and thus non-specific effects, into account.
Vaccines are simply tested for their specific protective effects + short-term adverse events and thats it.
sciencedirect.com/science/articl…
Vaccines are simply tested for their specific protective effects + short-term adverse events and thats it.
sciencedirect.com/science/articl…
This is a gigantic problem.
Heard about the malaria RTS,S 💉 story?
GSK💉tested in big 3-country RCT; showed modest effect against milder forms of malaria (not even the severe forms) --> approved by the EMA and cherished in the media, "historic moment": theconversation.com/who-approved-a…
Heard about the malaria RTS,S 💉 story?
GSK💉tested in big 3-country RCT; showed modest effect against milder forms of malaria (not even the severe forms) --> approved by the EMA and cherished in the media, "historic moment": theconversation.com/who-approved-a…
New study from Vietnam confirms Peter Aaby's observations on measles:
Compared with unvaccinated uninfected children, measles infected children had higher risk of hospitalisation in the first month, but thereafter their risk was substantially lower. bmcinfectdis.biomedcentral.com/articles/10.11…
Compared with unvaccinated uninfected children, measles infected children had higher risk of hospitalisation in the first month, but thereafter their risk was substantially lower. bmcinfectdis.biomedcentral.com/articles/10.11…
Measles infection seems to train the immune system so it becomes better at defending itself against other unrelated disease organisms in the future.
But of course, this training comes with the risk of becoming severely ill from the infection itself. academic.oup.com/aje/article/14…
But of course, this training comes with the risk of becoming severely ill from the infection itself. academic.oup.com/aje/article/14…
A safer way to obtain the immune training is measles vaccine, a live attenuated vaccine, which basically can be seen as a controlled way of getting a mild measles infection. Measles vaccine is also associated with lower risk of other infections. #NSEvac jamanetwork.com/journals/jama/…
Fatal sepsis🧵(1/14)
Sepsis is a leading cause of death in the first months of life and nearly half of under-5 deaths occur in the neonatal period.
There are no specific vaccines available to prevent neonatal sepsis, which is caused by a wide range of bacterial agents, but
Sepsis is a leading cause of death in the first months of life and nearly half of under-5 deaths occur in the neonatal period.
There are no specific vaccines available to prevent neonatal sepsis, which is caused by a wide range of bacterial agents, but
we have shown across 3 BCG vs no-BCG RCTs conducted in 🇬🇼 that the beneficial non-specific effects (#NSEvac) of at-birth BCG vaccination more than halves the risk of fatal neonatal sepsis among hospitalized newborns: academic.oup.com/jid/article-ab…
Likely immunological mechanisms (2/14)
Likely immunological mechanisms (2/14)
are BCG-induced 1) emergency granulopoiesis (science.org/doi/10.1126/sc…) & 2) trained immunity (nature.com/articles/s4157…)
In a meta-analysis of 4 🇬🇼 RCTs, providing BCG at birth reduced fatal neonatal non-TB infections by 40% (11% to 60%), see Table 4: academic.oup.com/jid/article-ab… (3/14)
In a meta-analysis of 4 🇬🇼 RCTs, providing BCG at birth reduced fatal neonatal non-TB infections by 40% (11% to 60%), see Table 4: academic.oup.com/jid/article-ab… (3/14)
NEW PAPER OUT. We investigated the effect of rabies vaccine on the mortality of Danish pigs. Why did we do that - Danish pigs do not get rabies?
Here follows an explanation and the results of the study. #NSEvac sciencedirect.com/science/articl…
Here follows an explanation and the results of the study. #NSEvac sciencedirect.com/science/articl…
Our group has found that many child vaccines have important non-specific effects #NSEvac, affecting the risk of other infections. Live vaccines have beneficial #NSEvac. Non-live vaccines, in contrast, have been observed to have harmful #NSEvac in females. thelancet.com/journals/lanin…
In 2016, analysing data from a trial of a new non-live malaria vaccine (RTS,S), we found that girls had 2-fold higher all-cause mortality if they received RTS,S vs. a control vaccine. The RTS,S group also had more cerebral malaria and meningitis. mbio.asm.org/content/7/2/e0…
The statements put forward by @GVDBossche have created anxiety. @GVDBossche has invited to discussion, but few scientists seem to have replied. The lack of response seems to generate more anxiety. I have received many requests to give my take and felt obliged to do so. 1/n
First a few words on my background: I am an MD working in epidemiology/global health>27 years. Our studies show non-specific effects of vaccines on other infections #NSEvac; I therefore also did immunological vaccine studies to understand mechanisms. 2/n thelancet.com/journals/lanin…
My main interest in COVID-19 vaccines is whether these new vaccines also have #NSEvac (So far none of them have been studied for their effect on other infections). Thus, vaccine immunology is not my main area, but I do know more than most. Hence my feeling of obligation. 3/n
ORAL POLIO VACCINE (OPV) – SOME CLARIFICATION. I’m a big OPV fan, but when I write about OPV I get negative feedback. So time to go through why I’m a fan and explain why I don’t see the same problems as some people do. Ready to get assumptions challenged? Follow this thread (1/n)
OPV was developed in the 1950s. At that time, polio was a problem. Epidemics followed epidemics, and though most people had asymptomatic disease, at its peak in the 1940s and 1950s, polio would paralyze or kill over 500,000 people worldwide every year (2/n)
After the introduction of the two polio vaccines, OPV and the inactivated polio vaccine (IPV), the incidence decreased. Cases due to wild poliovirus decreased by over 99% since 1988, from an estimated 350,000 cases then, to 33 reported cases in 2018 (3/n) who.int/en/news-room/f…
