Discover and read the best of Twitter Threads about #NanoMedicine
Most recents (2)
Excited to share our work on subcutaneous administration of hydrophobic, vesicant anticancer drugs via water-soluble polymer prodrugs out in @J_A_C_S Wonderful team effort! @ERC_Research @UnivParisSaclay @CNRS @INC_CNRS @CNRSIdFSud @Pharma_UPSaclay doi.org/10.1021/jacs.2…
🧵1/n
🧵1/n
👉 Chemotherapy is almost exclusively administered intravenously (IV) which has serious limitations:
➡️Patient discomfort (central route🩸, catheter failure…)
➡️Frequent hospital stays🏥, trained staff🩺👨⚕️needed…
➡️Costly (and cost will 📈 as new cancer cases will 📈)
🧵2/n
➡️Patient discomfort (central route🩸, catheter failure…)
➡️Frequent hospital stays🏥, trained staff🩺👨⚕️needed…
➡️Costly (and cost will 📈 as new cancer cases will 📈)
🧵2/n
What about other administration routes?
➡️Oral route 💊: very restrictive. Low and variable bioavailability. Chemo requires precise dosing.
➡️Subcutaneous (SC) route 💉: not possible for vesicant/irritant drugs because of skin ulceration 🚨 and even necrosis ☠️
🧵3/n
➡️Oral route 💊: very restrictive. Low and variable bioavailability. Chemo requires precise dosing.
➡️Subcutaneous (SC) route 💉: not possible for vesicant/irritant drugs because of skin ulceration 🚨 and even necrosis ☠️
🧵3/n
1. This thread is about an interesting clue @CzebotarJessie inspired me to look into- #architecture. Apparently, certain masonic architects, such as #FrankLloydWright, designed structures, which can indicate either a safe house, a house where sex & rituals can take place etc. 
Many houses have a network of tunnels underneath them. From the outside, it is hard to tell, but for instance, looking at the #WHWinslowResidence, the stairs from the pantry, could indicate an entrance to the tunnels.
2. The #IsidoreHHeller house however is possibly telling an interesting story. Originally owned by an Austrian butcher, Isidore H. Heller, who worked at Wold Sayer & Heller Packers & Butcher's Supplies. #FrankLoydWright designed this house in 1897.
