Discover and read the best of Twitter Threads about #Nanoparticle

Most recents (4)

Our latest paper describing #universal #CoV vaccine that can protect against #MERSCoV and #SARSCoV is now out⁩ in #preprint@YaleMed⁩ ⁦

Short thread 👇🏼

“Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice” biorxiv.org/content/10.110…
We were interested in developing vaccination strategies against highly pathogenic human #coronaviruses with epidemic potential. Our previous studies, and those of others, defined the #RBD as a major target of neutralizing antibodies.
We therefore looked to #ferritin nanoparticles as a scaffold to display genetically divergent RBDs from both Group 2c merbecoviruses (#MERSCoV) and Group 2b sarbecoviruses (#SARSCoV , #SARSlike viruses, and #SARSCoV2). Our vaccines elicited broad binding antibodies in mice.
Read 6 tweets
26/50 The detected "SV40 promoter with 72bps indel" is a "nuclear localization signal" that means either the #plasmid or one of its expressed proteins can be transported into host cell nuclei,...
27/50 ...where the host DNA is found, creating an open question of whether host DNA interaction will occur and to what effect e.g. integration with human DNA. anandamide.substack.com/p/sequencing-o…
28/50 Potential effects of plasmid #contamination in vivo? Notable, five chemistry professors from German universities have been studying #Pfizer #BionTech's covid vaccine. They addressed some questions to the company. Where does the gray tone come from?
berliner-zeitung.de/gesundheit-oek…
Read 29 tweets
Finally, the thread (you didn't know) you have been waiting for 🥳 "How can we use X-ray scattering to learn about the way the atoms sit in a #small #nanoparticle?" - lets use the Pair Distribution Function #PDF ! It's all about the neighbors 1/6 /@RPittkowski
To get information from small #nanoparticles, where periodic lattice planes are rare, we measure the X-ray scattering to very large scattering angles. This is called #Xray #totalscattering. So we need to come veeeery close with the detector to our sample.😱😬 2/6
Again, we integrate our scattering image (check up older tweets), but we are not done yet. More data treatment is necessary. We use a #Fouriertransform and transform from reciprocal (Q) space to #real #space - and there we have it, our PDF 😍3/6
Read 6 tweets
So we did a thing! As final goal of our @ZWCluster project #Electroflex we made a series of videos showing a glimpse of the infrastructure that the partners has on #Electrochemistry #Metals
#Thread
Here's one from @VITObelgium about electrochemical cells-
About #Electrode production @VITObelgium -
ZETA POTENTIAL AND HYDRODYNAMIC DIAMETER-
Read 12 tweets

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