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#NEPHTWEETORIAL #NEPHKIDS2020 LET'S TALK HYPOCALCEMIA!Ever wonder why we supplement 👶🏽 with Calcium while we're correcting Vitamin D deficiency/insufficiency?🤔More on that at the end of tweetorial! Let's deep-dive into physiology now!🏊🏽♂️🔽 @nikhil_Lohiya @jpsugumar @IPNA_PedNeph
99% of calcium is in 🦴. Of the tightly regulated serum calcium, 45% is albumin-bound 🤝, 55% is diffusible 💥(ionized Ca2, complex with HCO3 & Citrate). onlinelibrary.wiley.com/doi/abs/10.100…
Calcium homeostasis is intimately regulated by
🌜Parathyroid Hormone (PTH)
🌜Calcitonin
🌜Active Vitamin D
Whenever there's a drop⚠️⏬ in Calcium levels, 🦇 signal is sent out by Parathyroid glands to osteoclasts to release calcium from 🦴 via PTH.
🌜Parathyroid Hormone (PTH)
🌜Calcitonin
🌜Active Vitamin D
Whenever there's a drop⚠️⏬ in Calcium levels, 🦇 signal is sent out by Parathyroid glands to osteoclasts to release calcium from 🦴 via PTH.
#NEPHTWEETORIAL #NEPHKIDS2020 LET'S TALK DEHYDRATION!🥵 Welcome to our first tweetorial where we'll be discussing the pathophysiology of dehydration🤯& try and answer the WHAT, WHY, WHERE, WHEN, HOW in management.🤔 -@jpsugumar @IPNA_PedNeph
Our 👫🏽 body resembles the composition of Mother🌎. We're 2/3rd 💦 Let's look at this conceptual classification to understand which compartment of our 👫🏽 are affected the most according to underlying etiology. 
Similar to the droughts affecting our agricultural lands, DEHYDRATION affects our internal mileu resulting in physiological disturbances. 🌱🌾➡️🥀🍂
(from Askew EW. Water. In: Ziegler EE, Liler LJ, eds. Present Knowledge in Nutrition. 7th ed. Washington, DC: ILIS; 1996:98–108)
(from Askew EW. Water. In: Ziegler EE, Liler LJ, eds. Present Knowledge in Nutrition. 7th ed. Washington, DC: ILIS; 1996:98–108)
CKD-MBD - a commonly overlooked complication in our patient population
And one of the most under-prescribed drug (atleast in India) in the armamentarium is Cinacalcet
Here's a short thread on calcimimetics
#medtweetorial #nephtweetorial #iqraakidneyclub
And one of the most under-prescribed drug (atleast in India) in the armamentarium is Cinacalcet
Here's a short thread on calcimimetics
#medtweetorial #nephtweetorial #iqraakidneyclub
Mechanism of action?
As the name says -- a 'calcium' mimetic
Makes the CaSR in the parathyroid gland feel there's 'too much' calcium and suppresses PTH
As the name says -- a 'calcium' mimetic
Makes the CaSR in the parathyroid gland feel there's 'too much' calcium and suppresses PTH
How is it different from Active Vitamin D analogues?
While both aim to suppress PTH, their actions on Ca x P and FGF 23 levels are different
This could turn out to positively effect mortality outcomes? Let's find out
While both aim to suppress PTH, their actions on Ca x P and FGF 23 levels are different
This could turn out to positively effect mortality outcomes? Let's find out
🌍Earth's temp🌡️ has ⬆️ 0.8°C in the past decades🤨
Is this changing pattern of climate threatening 👀 kidney health❓
Let's find out why this global rise in temp concerns nephrologists so much❓
🌍🔥🌍🔥🌍🔥
💥Tweetorial alert 💥
#NephMadness #NephTweetorial #NSMC
Is this changing pattern of climate threatening 👀 kidney health❓
Let's find out why this global rise in temp concerns nephrologists so much❓
🌍🔥🌍🔥🌍🔥
💥Tweetorial alert 💥
#NephMadness #NephTweetorial #NSMC
What makes the kidneys more susceptible to acute injury from climate change?
Kidney is an amazing organ🙃🙂
⚡️It excretes concentrated waste ( To minimize fluid loss)
⚡️It is highly metabolic work🥵🥶
⚡️It excretes concentrated waste ( To minimize fluid loss)
⚡️It is highly metabolic work🥵🥶
