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Most recents (11)
Long-standing unwanted & unpleasant genital sensations in a woman of neurological origin
1. 41-year old woman presented with 3-year history of persistent abnormal sensations involving vagina, #clitoris and labia, without #sexual interest or #desire.
#MedTwitter #neurotwitter
1. 41-year old woman presented with 3-year history of persistent abnormal sensations involving vagina, #clitoris and labia, without #sexual interest or #desire.
#MedTwitter #neurotwitter
2. She found it hard to describe the sensations but used terms like vibrating, tingling, painful, throbbing, pulsating and numbness in vagina & surrounding regions. There was a sense of imminent #orgasm. Sexual activity & orgasm, however, did not relieve her symptoms.
3. Symptoms got worse on sitting and on lying down, but were lesser on standing or walking. Tight clothing or underwear aggravated her symptoms. She also had #pain in both legs, and felt the urge to constantly move her legs to reduce pain & discomfort (in legs & feet).
#1 #Covid19 #Supplement thread for #LongCovid #LongHaul #PostCovid. This may help, if you suffer from #fatigue #brainfog #jointpain #inflammation #weakness #depression #anxiety #SOB #clots #fibrosis #myocarditis #heartattack #stroke #alz #memory frontiersin.org/articles/10.33…
#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…
#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…
Briefly, @walterlekh and others in the #OSINT community. Question about usage of #nerve agents (more likely than blister or irritant) and how to protect oneself. Carbon filters are essentially the best barriers available on the ground (car air filters for example).
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#Organophosphate poisoning is punctuated by “excessive parasympathetic” nerve tone - think the “rest and digest” but in overdrive. This causes excessive salivation, bronchoconstriction (wheezing), lacrimation (tearful), airway secretions, flushing, diarrhea, vomiting, …
…muscle tremors, constricted pupils, sweating, and confusion. The first symptoms are usually salivation (makes sense; quickest to react). Treatment is atropine and 2-PAM Chloride (see Mark I Kit).
This is the most straightforward explanation for chronic symptoms in at least a subset of #LongCovid patients. Partly b/c if the #virus is still present its activity can directly contribute to other phenomena also being documented in LongCovid
2/ Persistence of #SARS-CoV-2 in tissue could lead to shedding of spike protein into blood, which can catalyze the ongoing formation of microclots and hyperactivated platelets
3/ Persistence of SARS-CoV-2 can lead to ongoing downregulation of interferon and/or T cell signaling by the virus, creating an optimal atmosphere for activation of EBV or other #pathogens normally controlled by such immunity
In a meeting I watched today, microglia priming was mentioned in #LongCovid and #ME/CFS. It’s important to clarify what “microglia priming” means. Microglial priming does not mean that after a trigger has “cleared” microglia remain perpetually activated
2/ Instead, microglia priming goes like this 👉 When microglia or other glial cells detect #infection, injury, or inflammatory mediators, they enter a state of activation in which they change morphology and release their own neuroexcitatory inflammatory mediators
3/ Then, after activating, they retain a “primed” functional state which causes an even more robust response to *subsequent* infectious/immune/#inflammatory challenges. And as cells, microglia live long lives (they are not replaced as often as many other cell types)
Important paper 👉 A team in Tokyo took RNA-seq data from the Genomic-#Tissue Expression Project: a public resource created to study tissue-specific gene expression/regulation from 54 tissue types collected from 1000+ healthy individuals at autopsy: bmcbiol.biomedcentral.com/articles/10.11…
2/ They successfully identified 39 viral species in at least one tissue (tissue types included #brain, pituitary, esophagus, thyroid, #heart, breast, lung, kidney, adrenal gland, prostate, #nerve, adipose tissue, blood vessel, ovary, uterus etc)
3/ Viruses identified in the various tissue samples included EBV, HSV-1, Varicella, CMV, HHV6-A/B, HHV-7, HCV, HPV, adeno-associated virus...and 16 RNA #viruses including Respiratory syncytial virus (RSV), Parainfluenza Virus 3..
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Cool new study which found that a range of #pathogens (some capable of long-term persistence in tissue + #blood) upregulate expression of the cell surface protein CD47 in the host cells they infect as an #immune evasion strategy
2/ I fact, upregulation of CD47 is a very smart survival strategy by such pathogens, b/c it interferes w/ the host innate immune response that is normally supposed to identify, target and kill them!
A question a day! Questions you always wanted to ask your friendly #neuromuscular doc. #neurology #medtwitter #MedEd #medstudent #neurologyresident Short answers only. Join me in discussing/learning/educating with #passion and #humor @WNGtweets @AANEMorg @AANMember
More on #myastheniagravis we are #onaroll Q: Doc doc. The single fiber EMG is positive for this patient. Ain’t got nothing else. He’s weak so he’s got #myastheniagravis. Right? Right?
A: Congratulations, padawan. The most sensitive #neuromuscular test, you have. #myastheniagravis, it could be. #ALS, it could be. #myositis, it could be. Any disease which affects #muscle, #nerve or #NMJ, it could be. Seek to find what ye are looking for. #Yoda
When Europe bans something that Africans have mastered (like ganga), our puppet leaders are quick to adopt it & disadvantage us. But when they ban something truly dangerous, like aluminum cooking utensils, our leaders will ignore it, because they really don't GAF about our health
If you have never thought about it, pls do so today.... Where is the other half of that aluminum ladle or spoon??? Unlike the "dad3s3n" which was a cast iron pot (still inferior to the Clay pot, but more later) these aluminum cooking pots are a serious health hazard.
The proof is very simple. Break (so there is no metal contact) fresh kontomire into 3 cooking pots containing water. One clay, one cast iron (or stainless steel) and one aluminum pot. Boil for 10 mins. Remove samples from each & place on a clean white cloth to inspect ...
“If borne out by subsequent studies, this paper will be a paradigm shift showing that #pain-sensitive #nerve cell terminals are not in fact always directly driven by a painful stimulus but instead can be driven by associated [Schwann] cells” —Prof Peter McNaughton, IC London
Here’s the formal paper 👉 Working in mice, the team discovered that Schwann cells (a type of #glial cell) can sense #pain (this was not known before!)☝️these Schwann cells wrap around nearby neurons which can further transmit pain signals to the brain: science.sciencemag.org/content/365/64…
One reason the discovery interests me is b/c #infection of Schwann cells can really dysregulate their function 👉 For example mycobacterium leprae can infect Schwann cells in a manner that results in peripheral #neuropathy and even changes in ATP levels: journals.plos.org/plosntds/artic…
