Discover and read the best of Twitter Threads about #NeuroImmunology

Most recents (6)

Hi, my friends! Today is my (@AlexisSMobley / she/her/hers) takeover! I'm running on #SpoonieTime, but we're also going to #ReclaimOurTime talking about accessibility and accommodations! 1/ A picture of Alexis Mobley, a Black woman, outside of a red
A little bit about me, I'm a doctoral researcher at @MDA_UTHGrad in the @NeuroMDAUTH and Immunology Programs. You can learn more about my research here:
I love the #NeuroImmunology research I do! 2/
I'm also a co-founder, President, and Treasurer of @BlackInImmuno where we amplify, celebrate, and support Black voices in immunology. 3/
Read 6 tweets
1/ These new interesting insights could provide answers for #MEcfs and #LongCovid.

"Researchers tracked antigens and other substances crossing the arachnoid barrier (known for his impermeability) but they found leaks in this particular area" #LeakyBrain
quantamagazine.org/how-the-immune…
2/ "Immune cells are waiting there. When these cells find a worrisome antigen, like one that suggests disease, they initiate a chain reaction that creates an immune response" #NeuroImmunology
3/ “Immune surveillance of the brain takes place. It’s absolutely normal, like in any other tissue,” said Jonathan Kipnis. “The only exception is that instead of this happening within the tissue, the brain pushed all its immune activity to its borders.”
Read 5 tweets
1/ Classic #opticneuritis is characterized by a sub-acute loss of vision in one Eye, with central #scotoma, pain on #eyemovement, positive #RAPD
- Fundus exam is usually normal
- Age range 15-45 years
2/Talking about #MOGAntibodies:
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
Read 10 tweets
@VirusesImmunity latest neuro story is up on biorxiv! biorxiv.org/content/10.110…
We used brain organoids, K18-hACE2 mice and our recently described AAV-hACE2 mice to show the neuroinvasive potential of SARS-CoV-2. A huge collaborative effort, so we have a lot to share. Here we go...
We started off by infecting some human brain organoids that my classmate Ce Zhang has been growing for the past few years. Check out these beautiful images that he took (more to come). We saw increasing amounts of cells infected over time.
Our collaborator Tamas, Yuki and Klara took some beautiful EM images for us to confirm the infection, along with viral particles budding off of the ER structures.
Read 18 tweets
THE PROMISED NEUROLOGY FELLOWSHIP THREAD: I’ve taken it upon myself to hype up neurology despite being under the tutelage of medicine for the next year. Neurology gets left behind when students resolve never to live in a world where ‘dysdiadochokinesia’ is used unironically.
Disclaimer: This thread is NOT comprehensive. Neurologists practice in vast spectrums that cannot be conveyed here. This is simply meant to inform prospective applicants about the options within the field of neurology, and hopefully, to entice them to explore something(s) new.
1/ #movementdisorders (MD)- starting out this thread with a backslap to naysayers who still make the tired claim that “there’s no instant gratification in neurology.” WRONG!
Read 48 tweets
More on immune evasion in glioblastoma! Online now in @NatureMedicine, intracranial tumors drive sequestration of T cells in the bone marrow through downregulation of S1PR1 receptor surface expression. nature.com/articles/s4159…
GBM patients, including treatment-naive, and mice with a variety of intracranial tumors (regardless of tumor origin) show extremely low levels of circulating T cells and reduced spleen size, with accompanying increase in bone marrow T cells (especially naive T cells).
This seems to be due to lower S1PR1 on T cells, driven by ligand-independent internalization (RNA levels are identical between control and tumor-bearing mice and there is no increase of S1P in the tumor-bearing mice).
Read 16 tweets

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