Discover and read the best of Twitter Threads about #Neuroimmunology
Most recents (7)
🚨 Alert! We are excited to share our new preprint in which we define the roles of individual class I molecules on brain endothelium in the regulation of T cell responses and development of neuropathology in experimental cerebral malaria
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
CD8 T cell engagement of brain vasculature has been implicated in the neuropathology of cerebral malaria. In this work we interrogated human and mouse data during infection and noted upregulation of activation and Ag-presentation molecules or transcripts in brain endothelium 
When either class I was ablated, the mice were normal at baseline and also established normal peripheral plasmodium infection and peripheral immune responses. However, T cell interactions with brain endothelium were disrupted during infection
Hi, my friends! Today is my (@AlexisSMobley / she/her/hers) takeover! I'm running on #SpoonieTime, but we're also going to #ReclaimOurTime talking about accessibility and accommodations! 1/
A little bit about me, I'm a doctoral researcher at @MDA_UTHGrad in the @NeuroMDAUTH and Immunology Programs. You can learn more about my research here:
I love the #NeuroImmunology research I do! 2/
I love the #NeuroImmunology research I do! 2/
I'm also a co-founder, President, and Treasurer of @BlackInImmuno where we amplify, celebrate, and support Black voices in immunology. 3/
1/ These new interesting insights could provide answers for #MEcfs and #LongCovid.
"Researchers tracked antigens and other substances crossing the arachnoid barrier (known for his impermeability) but they found leaks in this particular area" #LeakyBrain
quantamagazine.org/how-the-immune…
"Researchers tracked antigens and other substances crossing the arachnoid barrier (known for his impermeability) but they found leaks in this particular area" #LeakyBrain
quantamagazine.org/how-the-immune…
2/ "Immune cells are waiting there. When these cells find a worrisome antigen, like one that suggests disease, they initiate a chain reaction that creates an immune response" #NeuroImmunology
3/ “Immune surveillance of the brain takes place. It’s absolutely normal, like in any other tissue,” said Jonathan Kipnis. “The only exception is that instead of this happening within the tissue, the brain pushed all its immune activity to its borders.”
Good Morning #MedTwitter #neurotwitter #MedEd #Neurotwt #Neuroresidents #NeuroOphthalmology #Neuroimmunology #twittorial. Let's have a quick review on #OpticNeuritis and #NMO - Grab a #coffee and let's Start!
1/ Classic #opticneuritis is characterized by a sub-acute loss of vision in one Eye, with central #scotoma, pain on #eyemovement, positive #RAPD
- Fundus exam is usually normal
- Age range 15-45 years
- Fundus exam is usually normal
- Age range 15-45 years
2/Talking about #MOGAntibodies:
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
@VirusesImmunity latest neuro story is up on biorxiv! biorxiv.org/content/10.110…
We used brain organoids, K18-hACE2 mice and our recently described AAV-hACE2 mice to show the neuroinvasive potential of SARS-CoV-2. A huge collaborative effort, so we have a lot to share. Here we go...
We used brain organoids, K18-hACE2 mice and our recently described AAV-hACE2 mice to show the neuroinvasive potential of SARS-CoV-2. A huge collaborative effort, so we have a lot to share. Here we go...
We started off by infecting some human brain organoids that my classmate Ce Zhang has been growing for the past few years. Check out these beautiful images that he took (more to come). We saw increasing amounts of cells infected over time.
Our collaborator Tamas, Yuki and Klara took some beautiful EM images for us to confirm the infection, along with viral particles budding off of the ER structures.
THE PROMISED NEUROLOGY FELLOWSHIP THREAD: I’ve taken it upon myself to hype up neurology despite being under the tutelage of medicine for the next year. Neurology gets left behind when students resolve never to live in a world where ‘dysdiadochokinesia’ is used unironically.
Disclaimer: This thread is NOT comprehensive. Neurologists practice in vast spectrums that cannot be conveyed here. This is simply meant to inform prospective applicants about the options within the field of neurology, and hopefully, to entice them to explore something(s) new.
1/ #movementdisorders (MD)- starting out this thread with a backslap to naysayers who still make the tired claim that “there’s no instant gratification in neurology.” WRONG!
More on immune evasion in glioblastoma! Online now in @NatureMedicine, intracranial tumors drive sequestration of T cells in the bone marrow through downregulation of S1PR1 receptor surface expression. nature.com/articles/s4159…
GBM patients, including treatment-naive, and mice with a variety of intracranial tumors (regardless of tumor origin) show extremely low levels of circulating T cells and reduced spleen size, with accompanying increase in bone marrow T cells (especially naive T cells).
This seems to be due to lower S1PR1 on T cells, driven by ligand-independent internalization (RNA levels are identical between control and tumor-bearing mice and there is no increase of S1P in the tumor-bearing mice).
