Discover and read the best of Twitter Threads about #Neurological
Most recents (23)
Have you ever heard of glutamate excitotoxicity? No? Well, settle in for a thread. You're going to need to know about this fascinating (and slightly scary) topic that's essential to understanding brain health. 🧵 (1/30)
Glutamate is an excitatory neurotransmitter. You need some constantly being released and taken up by neurons to keep the brain functioning. It is critical to properly function several brain pathways essential for mood and cognitive function. (2/30)
In the prefrontal cortex, glutamate signaling is necessary for executive functions like decision-making, working memory, and attention. When glutamate signaling is functioning properly, it's a very good thing! (3/30)
Microcytic anemias, which affect all cell lines, can have adverse effects on brain and nervous system health. Iron deficiency #anemia, the most common type of microcytic anemia, can cause #cognitive impairment. 🧵(1/18)
Iron is crucial for #brain function, and its #deficiency can reduce #oxygen delivery to the brain, affecting #cognitive processes like #attention, #memory, and learning. (2/18)
#B12 deficiency, another common cause of microcytic anemia, can also damage the nervous system. (3/18)
Thread Alert 🧵: Let's talk about Parkinson's Disease 1/25 #Parkinsons #neurotwitter
In 2005 there was this study that, although very small, showed benefits. "Unified Parkinson’s Disease Rating Scale scores improved in all five during hyperketonemia" 2/25
n.neurology.org/content/64/4/7…
n.neurology.org/content/64/4/7…
It wasn't designed to rule out a placebo effect. But the result should have resulted in excitement and further studies being done. 3/25
1/4 "In this cohort study, more #severe acute illness, a higher #Charlson #Comorbidity #Index score, and being #unvaccinated were associated with a higher risk of reporting #COVID19 symptoms lasting 28 days or more."
#Unvaccinated and #immune naive or #convalescent?
#Unvaccinated and #immune naive or #convalescent?
2/4 "Participants with #COVID19 were more likely to seek medical care for #diabetes, #pulmonary, #neurological, and #mental health–related #illness for at least 6 months after onset compared with their pre-#COVID #baseline health care use patterns."
3/4 "These findings may inform the risk-benefit ratio of COVID-19 #vaccination #policy."
#SARSCoV2 #CovidIsNotOver #PASC #LongCovid
All were not checked for viral reservoirs and/or persistence, not tested in upper and lower respiratory tract and in the gastrointestinal tract.
#SARSCoV2 #CovidIsNotOver #PASC #LongCovid
All were not checked for viral reservoirs and/or persistence, not tested in upper and lower respiratory tract and in the gastrointestinal tract.
A fascinating symptom in #neurology is #Alien Hand syndrome
If anyone has seen @StanleyKubrick ‘s great film Dr. Strangelove, you might have wondered what’s wrong with the titular character
His hand has a #mind of its own!!!
#cinema #neurotwitter #MedTwitter
If anyone has seen @StanleyKubrick ‘s great film Dr. Strangelove, you might have wondered what’s wrong with the titular character
His hand has a #mind of its own!!!
#cinema #neurotwitter #MedTwitter
Simplifying , for carrying out bimanual planned movements, we need a Supplementary Motor Cortex (SMA) (left frontal lobe). This communicates to the opposite side via the corpus callosum. Lesions in any will impair proper bimanual function and cause an “alien limb”#neuroanatomy
Frontal variant (left sma lesion) : Patient will have impulsive groping and difficulty releasing objects
Affects the dominant hand
Can be due to a #stroke, #degeneration
My patient impulsively grabs my hand (with his right hand) despite me telling him not to!
#neurotwitter
Affects the dominant hand
Can be due to a #stroke, #degeneration
My patient impulsively grabs my hand (with his right hand) despite me telling him not to!
#neurotwitter
A #runner who would #swing his left arm more than the right
1. I have been running outdoors for two years. Over a period of time, one gets familiar with fellow runners- specially their style, pace & endurance. This post is about one of those runners, who was a regular (like me)😆
1. I have been running outdoors for two years. Over a period of time, one gets familiar with fellow runners- specially their style, pace & endurance. This post is about one of those runners, who was a regular (like me)😆
2. He had one odd style- he would swing his right arm lesser than the left while #running or #walking.
He would continue in the same style for about 60-70 minutes of his #RUN.
His #pace was excellent- 60 minutes for a 10 km run.
#MedTwitter #neurotwitter
He would continue in the same style for about 60-70 minutes of his #RUN.
His #pace was excellent- 60 minutes for a 10 km run.
#MedTwitter #neurotwitter
3. Our interaction was limited to "Good mornings".
Six months had passed since I first saw him. At this point, I noted that I could outpace him on a few occasions (I was much slower than him to start with).
I had started to think about possibility of a #neurological #disease.
Six months had passed since I first saw him. At this point, I noted that I could outpace him on a few occasions (I was much slower than him to start with).
I had started to think about possibility of a #neurological #disease.
#eyes becoming smaller in evenings could be a sign of #neurological illness
1. I was seeing the last patient, on what had been a busy Monday. While counselling the patient's attendant (aged 45), I noticed that her left eye was smaller than the right.
#MedTwitter #neurotwitter
1. I was seeing the last patient, on what had been a busy Monday. While counselling the patient's attendant (aged 45), I noticed that her left eye was smaller than the right.
#MedTwitter #neurotwitter
2. On enquiry, she confirmed that her eyes were of equal size in mornings, but left eye became smaller as the day progressed. This was the case for the past 4-5 months. She had no other issues. This had been noted by her family members and friends too. An eye check up was normal.
3. I discussed with her that this could be a sign of #myasthenia gravis (MG) and asked for investigations. Repetitive nerve stimulation was normal. However, acetylcholine receptor antibody was high (8; normal value<0.25). The diagnosis of MG was confirmed. CT chest was normal.
SEMINAL ARTICLE re: #ICD11 Chapter 08 - Diseases of the #NervousSystem 🧠
Study Title: The #leptomeninges as a critical organ for normal #CNS development and function: first patient and public involved systematic review of #arachnoiditis (chronic #meningitis). @PLOSONE
Study Title: The #leptomeninges as a critical organ for normal #CNS development and function: first patient and public involved systematic review of #arachnoiditis (chronic #meningitis). @PLOSONE
LINK: journals.plos.org/plosone/articl… @PLOSONE
Abbreviations:
#CES- #CaudaEquina Syndrome
#DLM – Diseases of the #Leptomeninges
#ESI- #Epidural Steroid Injection
LM - #Leptomeninges
#LMF- #Leptomeningeal #Fibrosis
#NAA- #neuraxialanesthesia
PSR- PRISMA Systematic Review
Abbreviations:
#CES- #CaudaEquina Syndrome
#DLM – Diseases of the #Leptomeninges
#ESI- #Epidural Steroid Injection
LM - #Leptomeninges
#LMF- #Leptomeningeal #Fibrosis
#NAA- #neuraxialanesthesia
PSR- PRISMA Systematic Review
#SAH- #Subarachnoid Hemorrhage
#SAS- #Subarachnoid Space
Key Findings:
1. A varyingly described, and poorly characterized #CNS disease called #arachnoiditis (aka #adhesivearachnoiditis) was exhaustively systematically-reviewed for the first time.
#SAS- #Subarachnoid Space
Key Findings:
1. A varyingly described, and poorly characterized #CNS disease called #arachnoiditis (aka #adhesivearachnoiditis) was exhaustively systematically-reviewed for the first time.
THABETA protocol
To treatment #COVID vaccine #side_effect
This protocol is designed to detox from the #spike_protein amyloid after the #mRNA vaccine to avoid #long_Covid and to remove triggers for #autoimmune disease after vaccination.
To treatment #COVID vaccine #side_effect
This protocol is designed to detox from the #spike_protein amyloid after the #mRNA vaccine to avoid #long_Covid and to remove triggers for #autoimmune disease after vaccination.
1837 patients with different side effects post COVID mRNA vaccine or suffering from long Covid symptoms have and are using this protocol
Efficacy = 97%
Against: #Myocarditis, #pericarditis , #MS , #Billy's palsy , #insulin_resistance #vasculitis , and other autoimmune conditions
Efficacy = 97%
Against: #Myocarditis, #pericarditis , #MS , #Billy's palsy , #insulin_resistance #vasculitis , and other autoimmune conditions
1. N-acetyle cysteine: 2000 mg daily
NAC works as antidote for amyloid spike protein and removes proteins produced from ORF3a embedded in cell surface.
NAC works as antidote for amyloid spike protein and removes proteins produced from ORF3a embedded in cell surface.
As some of you know im suffering weird #neurological symptoms atm. The last week has been pretty awful. One of the weirder symptoms is called micrographia: writing getting smaller and smaller.
↙️ My writing on Tuesday (bad not awful day)
My writing on Wednesday (awful day) ↘️
↙️ My writing on Tuesday (bad not awful day)
My writing on Wednesday (awful day) ↘️
![The words: brief [blanked out] on extension Written in small](https://pbs.twimg.com/media/FEgYkNlXIAcXCzH.jpg)
Micrographia in itself *can* be an early sign of conditions like #Parkinsons
In patients with Parkinsons, closing their eyes whilst writing can often help mitigate micrographia
In patients with Parkinsons, closing their eyes whilst writing can often help mitigate micrographia
(in my case the rapid onset followed by rapid improvement makes me think / hope its just whatever the fuck is going on with my neuro-immunology not a sign of whats to come...😬)
1 What does Long Covid look like?
Where do symptoms occur?
🆘🆘Anywhere 🆘🆘
#Arms
#LongCovidKids #LongCovidKids #LongCovidKids
#Longcovid
Where do symptoms occur?
🆘🆘Anywhere 🆘🆘
#Arms
#LongCovidKids #LongCovidKids #LongCovidKids
#Longcovid
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
"#ChronicPain on the #Brain - 4 #Psychological Effects of Living With #pain"
1)
Researcg covering the different ways the brain processes pain show us that the brain reacts differently to short-term pain than it does to long-lasting pain. h-wave.com/blog/chronic-p…
1)
Researcg covering the different ways the brain processes pain show us that the brain reacts differently to short-term pain than it does to long-lasting pain. h-wave.com/blog/chronic-p…
2)contd....
When the body experiences the latter, it can change the #centralnervoussystem (CNS),& influence sensory, emotional,& modular circuits that would otherwise inhibit pain.
When the body experiences the latter, it can change the #centralnervoussystem (CNS),& influence sensory, emotional,& modular circuits that would otherwise inhibit pain.
3)contind.....
#chronicpain is now looked at as a #neurological #disease of it's own- comorbid with symptoms of #anxiety and #depression
#mesh injured are suffering on many levels....
Pleaee do NOT underestimate the psychological impact of living with daily chronic #pelvicpain
#chronicpain is now looked at as a #neurological #disease of it's own- comorbid with symptoms of #anxiety and #depression
#mesh injured are suffering on many levels....
Pleaee do NOT underestimate the psychological impact of living with daily chronic #pelvicpain
Brain imaging shows we're more empathetic to others' #pain if we share skin color. Explicit bias is equal in members of majority & minority groups, but implicit bias is higher in members of the majority, an impt finding for policing & medicine. /thread onlinelibrary.wiley.com/doi/full/10.10…
If you really want to make a change in the world, do something hard like #nonviolent #resistance. Read up and learn #satyagraha or change. It takes #strength & #courage; physical force is forbidden even in the so-called most favorable circumstances.
satyagrahafoundation.org/satyagraha-the…
satyagrahafoundation.org/satyagraha-the…
If your cause is #righteous, Gandhi believed, the movement would speak for itself.
My personal justification for it is #psychological/#neurological (#CNS/#HPA).
If you use #violence, well the one with the biggest #ego or the biggest ego-extension (guns, tanks, war) will win.
My personal justification for it is #psychological/#neurological (#CNS/#HPA).
If you use #violence, well the one with the biggest #ego or the biggest ego-extension (guns, tanks, war) will win.
Good Morning #MedTwitter #neurotwitter #MedEd #Neurotwt #Neuroresidents #NeuroOphthalmology #Neuroimmunology #twittorial. Let's have a quick review on #OpticNeuritis and #NMO - Grab a #coffee and let's Start!
1/ Classic #opticneuritis is characterized by a sub-acute loss of vision in one Eye, with central #scotoma, pain on #eyemovement, positive #RAPD
- Fundus exam is usually normal
- Age range 15-45 years
- Fundus exam is usually normal
- Age range 15-45 years
2/Talking about #MOGAntibodies:
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Important 👉 This team is investigating bacterial quorum sensing peptides (QSPs) as metabolites that can contribute to #microbiome-driven disease processes👆They identified QSPs that selectively influence functionality of several types of neuronal #brain cells including microglia
Their abstract concludes that 👉 "Combined with our in-vivo studies indicating that these QSP are permeating the #intestinal wall, as well as the blood-brain barrier, our findings may open up a new field of diagnostic and therapeutic approaches for #neurological disorders."
Rob Moir describes a similar phenomenon in this interview, stating 👉 "#Vagus Nerve traffic may include #bacterial signaling molecules called quorum sensing molecules. In this sense microbes in the gut and microbes in the brain may be “talking...": microbeminded.com/2017/12/18/int…
1/
I'm taking the #Coursera #Learning How to Learn course
bit.ly/1LqIUp4
This assignment is to teach others. I decided to make a giant thread for my coding community since you all give me so much.
#newDevCity
#100DaysOfCode
#CodeNewbie
#Study
#freeCodeCamp
@w3develops
I'm taking the #Coursera #Learning How to Learn course
bit.ly/1LqIUp4
This assignment is to teach others. I decided to make a giant thread for my coding community since you all give me so much.
#newDevCity
#100DaysOfCode
#CodeNewbie
#Study
#freeCodeCamp
@w3develops
@w3develops 2/
The course is teaching how learning happens. The course lessons are backed up by #neurological science. #Learning is not something only for the young, there are techniques that are easily obtainable to help you learn difficult subjects in any discipline.
#newDevCity
#Coursera
The course is teaching how learning happens. The course lessons are backed up by #neurological science. #Learning is not something only for the young, there are techniques that are easily obtainable to help you learn difficult subjects in any discipline.
#newDevCity
#Coursera
@w3develops 3/
"We ordinarily think of learning as something we do when we sit down to study a book. But actually, being able to learn more easily and deeply involves many important facets--including not only periods of focused concentration, but also periods of relaxation...
#newDevCity
"We ordinarily think of learning as something we do when we sit down to study a book. But actually, being able to learn more easily and deeply involves many important facets--including not only periods of focused concentration, but also periods of relaxation...
#newDevCity
Incredibly important hypothesis piece published today 👉 “Proposed here is a theory that #microorganisms from within the #brain and elsewhere in the body contribute to the long-term #neurological deterioration characteristic of traumatic brain injury”: sciencedirect.com/science/articl…
Yet another team ties #neuroinflammation to persistent brain infection 👉 Here, RNA seq + western blot + antibody testing identified pegvirus inside the #brain cells of two patients who died from encephalitis (and not controls): folio.ca/u-of-a-scienti…
Important that pegvirus acted as an intracelluar #pathogen (viral antigens were found inside glial cells + lymphocytes + astrocytes)☝️..w/ their presence in lymphocytes suggesting the “cells might serve as a Trojan horse for #viral infection of the brain parenchymal cells.”
Also important is that detection of #pegvirus-antigen in the pre-transplantation bone marrow biopsy of one subject 👉 “indicated that this patient was infected at least 15 years before #neurological presentation, suggesting a period of viral latency.”
Thread:
The 10 publications below provide scientific evidence that patients with #MECFS have #brain abnormalities in #neuroinflammation, #metabolism, #neurological connections and blood perfusion
#pwME suffer from #chronicillness
#pwME are #SickNotWeak
The 10 publications below provide scientific evidence that patients with #MECFS have #brain abnormalities in #neuroinflammation, #metabolism, #neurological connections and blood perfusion
#pwME suffer from #chronicillness
#pwME are #SickNotWeak
1. These studies “provide evidence of #neuroinflammation in #MECFS.. as well as evidence of the possible contribution of neuroinflammation to the pathophysiology of #MECFS”
#pwME
jnm.snmjournals.org/content/55/6/9…
#pwME
jnm.snmjournals.org/content/55/6/9…
2. This Australian study found abnormalities in the #brain MRIs and peripheral Blood Pressure and Heart Rate in #MECFS patients including the Vasomotor centre, midbrain and hypothalamus
#pwME
sciencedirect.com/science/articl…
#pwME
sciencedirect.com/science/articl…
