Discover and read the best of Twitter Threads about #Neutropenia
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Images of Infectious Diseases
GMS of sinus tissue of 20F with no PMH. She presented with fever and sinus pain. CT pansinusitis. Labs: WBC 1.7 ANC 0. Serum BDG and GM negative.
What is your differential diagnosis and empiric therapy? #MayoIDQ to follow...
GMS of sinus tissue of 20F with no PMH. She presented with fever and sinus pain. CT pansinusitis. Labs: WBC 1.7 ANC 0. Serum BDG and GM negative.
What is your differential diagnosis and empiric therapy? #MayoIDQ to follow...
2/
Histopath of surgically resected tissue shows fungal elements. You suggested Mucor/Rhizopus, Fusarium, Trichosporon.
Lack of serum BDG suggests Mucor/Rhizopus
The patient was started on AmBisome.
Few days later, the fungal culture of the same sinus sample shows (photo)
Histopath of surgically resected tissue shows fungal elements. You suggested Mucor/Rhizopus, Fusarium, Trichosporon.
Lack of serum BDG suggests Mucor/Rhizopus
The patient was started on AmBisome.
Few days later, the fungal culture of the same sinus sample shows (photo)
3/
#MayoIDQ Surgical debridement of the sinuses was performed plus liposomal Amphotericin B was initiated. Patient lives in rural MN and asks you if an oral option is available as step down Rx.
#MayoIDQ Surgical debridement of the sinuses was performed plus liposomal Amphotericin B was initiated. Patient lives in rural MN and asks you if an oral option is available as step down Rx.
Why does chemotherapy kill cancerous but not normal cells? Most cancer biologists would answer this by stating that chemotherapy is selectively toxic to proliferating cells, and that cancer cell proliferate more than normal cells. Not exactly - there's a lot more to it.
Many normal tissues, like bone marrow and gut cells are actually more proliferative than even the most aggressive cancers. E.g. pro-myelocytes have a doubling time of around 17 hrs whilst even aggressive epithelial tumors double every 2-3 weeks or so.
So while many chemotherpeutics (e.g. #Temozolomide for GBM) show extensive myelotoxicity as a side effect, clinically useful ones are able to kill cancerous cells more efficaciously than normal ones, even if the latter proliferate faster, like pro-myelocytes.
How do they do it?
How do they do it?
Missed #COVID19nCancer plenary in #AACR20 @AACR?
Here’s a thread to catch up on all the fascinating global research presented by:
@AACR @AACRPres #AntoniRibas #LiZhang @marinagarassino @barlesi #CarlosGomez #LouisVoigt #HongbingCai cc:@OncoAlert @COVID19nCCC @ASCO @ASH_hematology
Here’s a thread to catch up on all the fascinating global research presented by:
@AACR @AACRPres #AntoniRibas #LiZhang @marinagarassino @barlesi #CarlosGomez #LouisVoigt #HongbingCai cc:@OncoAlert @COVID19nCCC @ASCO @ASH_hematology
#1: Chinese Experience by #LiZhang and #HongbingCai
More evidence of increased prevalence of #Cancer among #COVID19, ~2% similar to what we found in our #metanalysis @ASCO_pubs #JCOGO here: ascopubs.org/doi/10.1200/GO…
More evidence of increased prevalence of #Cancer among #COVID19, ~2% similar to what we found in our #metanalysis @ASCO_pubs #JCOGO here: ascopubs.org/doi/10.1200/GO…
#LiZhang described 35.7% required mechanical ventilation and significant risk factors for severe outcomes on #multivariate analysis was recent #cancertreatment and #consolidation on CT
