Discover and read the best of Twitter Threads about #Neutrophil
Most recents (8)
1) Welcome to a new #accredited #tweetorial on #Bronchiectasis (#NCFB or #bronchiectasis) & its management, by Christina Thornton MD (@Cthornton32), respirologist & clinician scientist in Calgary 🇨🇦. Follow along and earn 0.75h CE/#CME #physicians #nurses #NPs #PAs #pharmacists! 
2) I am very excited to be among the founding faculty in this initiative! FOLLOW US for awesome expert-led education #pulmtwitter!
đź‘Ť@BronchiectasisR @COPDFoundation @EMBARCnetwork @ELF @profJDchalmers @sunjayMD @DrHollyKeir @becleartoday @ephesians_1_7 @NTMinfo @AlibertiStefano
đź‘Ť@BronchiectasisR @COPDFoundation @EMBARCnetwork @ELF @profJDchalmers @sunjayMD @DrHollyKeir @becleartoday @ephesians_1_7 @NTMinfo @AlibertiStefano
3) This program is supported by an educational grant from Insmed & is intended for healthcare professionals. Statement of accreditation and faculty disclosures at pulmonarymed-ce.com/disclosures/. CE/#CME credit from @academiccme.
Excited to share our publication in @CellRepMed highlighting #neutrophil activation in #PostCovid #MISC!
Led by @bpboribong and Tom LaSalle (@harvardmed), plus coauthors @D__Irimia, @EdlowLab and more
cell.com/cell-reports-m…
@MGH_RI @MGH_Mucosalists @ragoninstitute @MassCPR
Led by @bpboribong and Tom LaSalle (@harvardmed), plus coauthors @D__Irimia, @EdlowLab and more
cell.com/cell-reports-m…
@MGH_RI @MGH_Mucosalists @ragoninstitute @MassCPR
Key points:
-even in mild Pedi COVID, neutrophils display IFN signaling
-Neutrophils in MISC show sepsis-like gene expression: high degranulation, TNF and IL-1 signaling
-Neutrophils in MISC *spontaneously* form #NETS intravascularly (can’t be good…)
(Read on…)
-even in mild Pedi COVID, neutrophils display IFN signaling
-Neutrophils in MISC show sepsis-like gene expression: high degranulation, TNF and IL-1 signaling
-Neutrophils in MISC *spontaneously* form #NETS intravascularly (can’t be good…)
(Read on…)
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
On day 14 of neutropenia, an astute ID fellow noted this finding (photo) while examining a patient with fever. Underlying AML and ongoing chemotherapy.
What do you suspect? What work up do you suggest? Details and #MayoIDQ MCQ to follow...
What do you suspect? What work up do you suggest? Details and #MayoIDQ MCQ to follow...
65M acute myeloid leukemia. Rx: CLAG-M. Prophy ACV, posaconazole, Levo, inhaled pentamidine
D14 neutropenia: fever / chills
Exam: onychomycosis, rapidly evolving lesions in arms and torso (photo)
You asked for skin biopsy. Blood culture will grow what fungus?
D14 neutropenia: fever / chills
Exam: onychomycosis, rapidly evolving lesions in arms and torso (photo)
You asked for skin biopsy. Blood culture will grow what fungus?
2/
Case diagnosis: disseminated fusariosis
Majority got the diagnosis correctly!
Blood culture: Fusarium sp.
Rx: AmBisome / voriconazole
Hope for neutrophil recovery!!!
Case diagnosis: disseminated fusariosis
Majority got the diagnosis correctly!
Blood culture: Fusarium sp.
Rx: AmBisome / voriconazole
Hope for neutrophil recovery!!!
As the elderly are more susceptible to #COVID19 w/ signs of lung #inflammation, here's a thread about our @virusesimmunity 2016 flu paper on #antiviral resistance, excessive lung #inflammation, & a strategy to boost disease tolerance! science.sciencemag.org/content/352/62…
First we demonstrated that monos & macs from older adults have impaired type I IFN (antiviral) & #ISG responses but intact cytokine responses after #flu infection. To probe the possible in vivo consequences of weak #IFN responses in the face of robust inflammation...
... we made a mouse model that mimicked this immune response in the elderly (Mx1+/+ mice w/ genetic deletion of tlr7, mavs). Failure to induce type I IFN led to high viral titer, 2Âş bacterial infection, severe lung inflammation, and death.
