Discover and read the best of Twitter Threads about #Neutrophils
Most recents (13)
Time for a deep dive into SARS-CoV-2 immunology after vaccination and infection. I’ll try to explain it also for non immunologists.
New observation: Booster mRNA vaccines induce antibody switch to IgG4, what does this mean?
science.org/doi/epdf/10.11…
pubmed.ncbi.nlm.nih.gov/36548397/
1/
New observation: Booster mRNA vaccines induce antibody switch to IgG4, what does this mean?
science.org/doi/epdf/10.11…
pubmed.ncbi.nlm.nih.gov/36548397/
1/
It is known that immune responses could either protect against disease or exacerbate disease.
Early non-neutralizing, afucosylated IgG1 antibody responses are associated with COVID-19 severity.
pubmed.ncbi.nlm.nih.gov/35040666/
pubmed.ncbi.nlm.nih.gov/36385627/
2/
Early non-neutralizing, afucosylated IgG1 antibody responses are associated with COVID-19 severity.
pubmed.ncbi.nlm.nih.gov/35040666/
pubmed.ncbi.nlm.nih.gov/36385627/
2/
Previously it was shown that the afucosylated IgG1 antibodies are only found after the first vaccination.
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
3/
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
3/
Did you know that some proteins can increase or *decrease* #CellMigration, depending on the cell type?
Check our review on how ion channels (#Pannexins) & #calciumsignaling regulate immune, non-immune & #cancer migration.
Hot from the press: readcube.com/articles/10.33… #SciComm
/1
Check our review on how ion channels (#Pannexins) & #calciumsignaling regulate immune, non-immune & #cancer migration.
Hot from the press: readcube.com/articles/10.33… #SciComm
/1
It all started when we wrote something with @palomi_rock
The intro was so good & had so much new data that we decided to make a 'short' review/update of pannexins in #immunecells, focus on cell migration.
But things got out of hand & we started to include more cell types 😅🤷🏽♂️
/2
The intro was so good & had so much new data that we decided to make a 'short' review/update of pannexins in #immunecells, focus on cell migration.
But things got out of hand & we started to include more cell types 😅🤷🏽♂️
/2
Then, @LpzLpz_Tami joined to help with migration of immune cells, such as #DendriticCells, #Tcells, #Neutrophils, and to do the beautiful figures @BioRender 😍
Next, @APalacio_s joined to bring a broader vision of migration's impact during neuroinflammation, senescence, etc
/3
Next, @APalacio_s joined to bring a broader vision of migration's impact during neuroinflammation, senescence, etc
/3
@lasleh @yleuutiset #Fimea @THLorg Covid-19 or #GrapheneOxide? Poisonous Nano-Material found in #CovidVaccines and #FaceMasks | JULY 10, 2021
- In Oct 2013 the #EuropeanUnion launched two flagship projects: the Human Brain Project (“HBP”); and, the Graphene Flagship (“GF”)
dailyexpose.co.uk/2021/07/10/the…
- In Oct 2013 the #EuropeanUnion launched two flagship projects: the Human Brain Project (“HBP”); and, the Graphene Flagship (“GF”)
dailyexpose.co.uk/2021/07/10/the…
@lasleh @yleuutiset @THLorg Official interim report of #Pfizer's vaccination vial analysis explained by La Quinta Columna | JUNE 30, 2021
- Prof. Dr. Pablo Campra #Madrid of the University of #Almeria, @ualmeria Spain
docdroid.net/file/download/…
- Prof. Dr. Pablo Campra #Madrid of the University of #Almeria, @ualmeria Spain
docdroid.net/file/download/…
@lasleh @yleuutiset @THLorg @ualmeria #SoyUAL Pablo Campra
Universidad de Almería | UAL · Department of Agronomy
PhD in Chemical Sciences
- Pablo Campra currently works at the Food Technology Division of the Department of Agronomy, University de Almeria (Spain)
researchgate.net/profile/Pablo-…
Universidad de Almería | UAL · Department of Agronomy
PhD in Chemical Sciences
- Pablo Campra currently works at the Food Technology Division of the Department of Agronomy, University de Almeria (Spain)
researchgate.net/profile/Pablo-…
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
#Azithromycin associated w/ #COVID_19 associated pulmonary #aspergillosis. OR 3.1 (1.1-8.5). Just published in @CMIJournal (bit.ly/2JN1fDS). Could it be a risk factor ? More on this hypothesis ⬇️ 1/5
#Azithromycin >1500mg in humans = inhibition of oxydative burst in #neutrophils up to 28 days after last dose. By Culic et al. (bit.ly/3mPkYkd) 2/5
#Neutrophils = first barrier against fungal infection. Oxydative burst necessary for NETs formation. Genetic defect in oxydative burst leads to CGD with well-known increased susceptibility to #aspergillosis (bit.ly/2VJu1aN). 3/5
How long do #neutrophils live? Are they all equal or do they adapt to tissues?
Get answers to these & more questions in our new paper just out online at @CellCellPress!
Led by our fabulous @AndreaRP88 & @ivanbamartin!
Key points in thread 👇
embargoed.www.cell.com/action/showFul…
Get answers to these & more questions in our new paper just out online at @CellCellPress!
Led by our fabulous @AndreaRP88 & @ivanbamartin!
Key points in thread 👇
embargoed.www.cell.com/action/showFul…
Neutrophils are almost ubiquitous in the body. At varying levels, but present in almost every tissue
This is a finding in line with our previous work by @Casanova_Acebes @NicolasAvilaJA & Jackson Li @JExpMed 2018
Excited to present our lab's preprint, exploring how neutrophils - the most abundant white blood cell - are influenced by organismal aging and biological sex! #neutrophils #sexdimorphism #aging
-- a thread --
biorxiv.org/content/10.110…
-- a thread --
biorxiv.org/content/10.110…
This is a new story developed at @USCLeonardDavis and led by Biology of Aging graduate student #RyanLu, which was developed thanks to a collaboration to awesome scientists and friends @KContrepois and #ShalinaTaylor at Stanford. 1/n
Neutrophils are unique because they can use their chromatin as a weapon to fight pathogens in a process termed 'NETosis'. They are extremely short-lived, surviving only ~6h after terminal differentiation, and have thus not been extensively studied throughout organismal aging. 2/n
Endothelial-derived microvesicles play a pathogenic role in vascular #inflammation, causing #endothelial barrier dysfunction by impairing adherens junctions and activating #neutrophils
More here: bit.ly/3g1FpH7
#Cardiotwitter #CardiovascularResearch
#Tweetorial below!
More here: bit.ly/3g1FpH7
#Cardiotwitter #CardiovascularResearch
#Tweetorial below!
#Microvesicles (MV) are formed from the outward blebbing of the plasma membrane and carry a diverse cargo that regulate multiple processes.
During #inflammation these are produced by activated endothelial cells and released into the #circulation. TEM image of plasma MVs: (2/8)
During #inflammation these are produced by activated endothelial cells and released into the #circulation. TEM image of plasma MVs: (2/8)
1 approach to understanding #covid19 infection is to examine co-morbidities & ask what's common?
Most prevalent Cov19 co-morbs:
1)↗️age
2)Hypertension
3)Diabetes
4)Cardiovascular disease
5)Kidney disease
6)Chronic respiratory disease (esp COPD)
8)Cancers
9)BMI>40
10)♂️>♀️
Most prevalent Cov19 co-morbs:
1)↗️age
2)Hypertension
3)Diabetes
4)Cardiovascular disease
5)Kidney disease
6)Chronic respiratory disease (esp COPD)
8)Cancers
9)BMI>40
10)♂️>♀️
2/
These are diverse diseases & increasing age technically not a disease at all. However, there is at least 1 factor in common among all of the co-morbidities identified thus far:
INFLAMMATION
These are diverse diseases & increasing age technically not a disease at all. However, there is at least 1 factor in common among all of the co-morbidities identified thus far:
INFLAMMATION
3/
A survey of the co-morbidities revealed another commonality; a close association w/ dysregulation of the pro-inflammatory, neutrophil-recruiting cytokine, IL-17A.
IL-17A is made by multiple immune cell types, including lung-resident innate lymphoid cells (ILC3s).
A survey of the co-morbidities revealed another commonality; a close association w/ dysregulation of the pro-inflammatory, neutrophil-recruiting cytokine, IL-17A.
IL-17A is made by multiple immune cell types, including lung-resident innate lymphoid cells (ILC3s).
CYTOF analysis of human neutrophils - 7 populations with differing phagocytosis, ROS, and FACS-compatible surface marker phenotypes. Changes in distribution between healthy + melanoma patients. #Immunology #Cancer #Neutrophils biorxiv.org/content/10.110…
Circulating neutrophil precursors, aged neutrophils, and a few populations of mature and immature neutrophils. Melanoma stage correlates with loss of dominant N2 (mature, ROS++, lowly phagocytic), and increase of N5 (immature, non-proliferative, ROS+, lowly phagocytic).
Interesting to note the phagocytosis-SSC staining in Fig4A - big changes in SSC for some populations with zymosan, others not so much - degranulation, different phagosomes…? Similarly, bimodal peaks for ROS production in same populations…
