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Dementia with Lewy Bodies:
Part 2️⃣ Biomarkers
🧠💊⚕️
#Neuro #Neurotwitter #Teaching #Education
#NotEverythingIsMemory
#Dementia
1/🧵
Part 2️⃣ Biomarkers
🧠💊⚕️
#Neuro #Neurotwitter #Teaching #Education
#NotEverythingIsMemory
#Dementia
1/🧵
Introduction
What is a biomarker? 🏷🧪️
"A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention." 🩸🧠
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What is a biomarker? 🏷🧪️
"A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention." 🩸🧠
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Introduction
What is the use of biomarkers? 🧠
Diagnostic tool🪓
Tool for staging the disease 🥼
Indicator of prognosis📡
Predic or monitor of clinical response to an intervention🚨
Remember: "tools"should aid clinicians, not be the source of all truth.
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What is the use of biomarkers? 🧠
Diagnostic tool🪓
Tool for staging the disease 🥼
Indicator of prognosis📡
Predic or monitor of clinical response to an intervention🚨
Remember: "tools"should aid clinicians, not be the source of all truth.
3/🧵
Dementia with Lewy Bodies:
Part 1️⃣ Clinical features and Probable Diagnosis
🧠📚🔖
#Neuro #Neurotwitter #Teaching #Education
#NotEverythingIsMemory
#Dementia
1/🧵
Part 1️⃣ Clinical features and Probable Diagnosis
🧠📚🔖
#Neuro #Neurotwitter #Teaching #Education
#NotEverythingIsMemory
#Dementia
1/🧵
Introduction 🥇
DLB belongs to a family of disorders typically known as "synucleinopathies" 🔬
Other members are:
- MSA
- PD
- PDD
All of them have abnormal inclusions of α-Synuclein at a pathological level.
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DLB belongs to a family of disorders typically known as "synucleinopathies" 🔬
Other members are:
- MSA
- PD
- PDD
All of them have abnormal inclusions of α-Synuclein at a pathological level.
2/🧵
⚠️⚠️⚠️
"Pathology is not pathogenesis", therefore we shouldn't assume that the presence of these pathological changes are a synonym of "protein toxicity".
Suggested reading ⬇️
jamanetwork.com/journals/jaman…
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"Pathology is not pathogenesis", therefore we shouldn't assume that the presence of these pathological changes are a synonym of "protein toxicity".
Suggested reading ⬇️
jamanetwork.com/journals/jaman…
3/🧵
