Discover and read the best of Twitter Threads about #NotYetPeerReviewed
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The latest results from @theSANBS, @The_WCBS, and #SACEMA on anti-SARS-CoV-2 seroprevalence among blood donors in South Africa are now available.
researchsquare.com/article/rs-168…
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researchsquare.com/article/rs-168…
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Congrats to @laurettemhlanga, @alex_welte, @Marionvermeulen, and the rest of the team!
TL;DR: as of mid-March 2022, prior to the BA.4/BA.5-driven resurgence, an estimated 98% of South Africans had antibodies from prior infection, vaccination, or both.
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TL;DR: as of mid-March 2022, prior to the BA.4/BA.5-driven resurgence, an estimated 98% of South Africans had antibodies from prior infection, vaccination, or both.
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This round of samples was tested using assays that detect different antibody types.
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[Thread] South Africa has seen a recent rapid rise in #SARSCoV2 cases & unprecedented number of reinfections.
We've been working on bounding the levels of transmissibility & immune evasion that could explain #Omicron's spread in 🇿🇦.
sacmcepidemicexplorer.co.za/downloads/Pear…
#NotYetPeerReviewed
We've been working on bounding the levels of transmissibility & immune evasion that could explain #Omicron's spread in 🇿🇦.
sacmcepidemicexplorer.co.za/downloads/Pear…
#NotYetPeerReviewed
We find that #Omicron is likely more transmissible than #Delta. This finding holds across a wide range of assumptions about immune evasion that are consistent with early neutralization studies.
Our analysis includes several steps.
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Our analysis includes several steps.
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First, we analyze trends in S-gene target failure (SGTF) at the provincial level. SGTF is a marker of #Omicron sublineage BA.1. Our updated model accounts for SGTF being an imperfect marker, & we now fit the model to data through 6 December.
UPDATE #Omicron
On ne sait toujours pas grand chose avec certitude, mais ça se précise
Thread court (plus sérieux que les 3 lignes du précédent)
Attention : #NotYetPeerReviewed
On ne sait toujours pas grand chose avec certitude, mais ça se précise
Thread court (plus sérieux que les 3 lignes du précédent)
Attention : #NotYetPeerReviewed
Il semble que le variant #omicron puisse réinfecter plus facilement (x 2,5 - 3 ?) les patients qui ont déjà été atteint par le #SARS_CoV_2 ce qui suggère que son avantage compétitif sur #delta pourrait provenir partiellement de cette caractéristique.
NĂ©anmoins l'Ă©tude qui le dit est encore en preprint.
Cette Ă©tude ne donne pas non plus d'information sur le statut vaccinal des individus inclus, ce qui ne permet donc pas d'Ă©valuer le risque d'Ă©chappement au vaccin de #Omicron
doi.org/10.1101/2021.1…
Cette Ă©tude ne donne pas non plus d'information sur le statut vaccinal des individus inclus, ce qui ne permet donc pas d'Ă©valuer le risque d'Ă©chappement au vaccin de #Omicron
doi.org/10.1101/2021.1…
As discussed at #EPIDEMICS8 breakout session, @saCOVID19mc have started characterizing the #SARSCoV2 variant #Omicron; working estimates for this new variant are critical so the globe can plan with the best information possible: drive.google.com/file/d/1hA6Mec…
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Based on S-Gene Target Failure (SGTF), we estimated #Omicron growth rate across RSA provinces. Gauteng has the clearest signal, and indicates growth of 0.21 (0.14, 0.27)/day, corresponding to a doubling time of 3.3 (2.5, 4.6) days.
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From that, we estimated relative effective reproductive #s for #Omicron & #Delta. In Gauteng, the ratio is ~2.4 (2.0, 2.7), assuming #Omicron has the same typical time between generations.
[n.b. this corrects fig from pres.; no change to other results]
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[n.b. this corrects fig from pres.; no change to other results]
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[Thread] We have updated our preprint on SARS-CoV-2 reinfection trends in South Africa to include data through late November. @hivepi @jd_mathbio @carivs @Dr_Groome @nicd_sa #SACEMA
doi.org/10.1101/2021.1…
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doi.org/10.1101/2021.1…
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We find evidence of increased reinfection risk associated with emergence of the #Omicron variant, suggesting evasion of immunity from prior infection. @scienceSUN @NRF_News
We developed 2 methods to monitor signatures of changes in reinfection risk & have used them to monitor reinfection trends in SA since Jan 2021.
@theSANBS, @The_WCBS, and #SACEMA have released new information on SARS-CoV-2 seroprevalence among blood donors in South Africa, including in the 5 provinces for which data were not previously available. #NotYetPeerReviewed
A full preprint will be released soon.
A full preprint will be released soon.
The new data are based on samples collected in May 2021, using the same methods as described in the earlier preprint from Sykes et al:
researchsquare.com/article/rs-233…
The study was led by @Marionvermeulen with data analysis by @laurettemhlanga, Dr Eduard Grebe, and Prof Alex Welte.
researchsquare.com/article/rs-233…
The study was led by @Marionvermeulen with data analysis by @laurettemhlanga, Dr Eduard Grebe, and Prof Alex Welte.
