Discover and read the best of Twitter Threads about #Nucleocapsid

Most recents (10)

1⃣
Wie wird #PostVac nachgewiesen?
Ein Thread für alle "verf*** Impffans" und #LongCovid Betroffenen, die angesichts der #PostVacFake Berichterstattung / Desinformation zu Impfschäden in Versuchung geraten, Geld für dubiose Tests auszugeben ⬇️ Image
2⃣
Um bei #MECFS / LongCovid Symptomen einen Zusammenhang zur Impfung nachweisen zu können, müssten logischerweise neben einem engen zeitlichen Zusammenhang verschiedene Sachen ausgeschlossen werden:
1. Mild verlaufene / unbemerkte Covid Infektion
2. Sonstige Vorerkrankungen...
3⃣
3. Sonstige virale / bakterielle Erkrankung im erweiterten Zeitraum bei Auftreten der Beschwerden
4. Psychosomatische Beschwerden oder psychische Vorerkrankungen in Zusammenhang mit Impfreaktionen und Nocebo Effekte
Read 35 tweets
1/4 "Using #PEPMatch, a newly developed #bioinformatics package which predicts #peptide similarity within specific #amino #acid mismatching parameters consistent with published #MHC binding capacity,..."

nature.com/articles/s4159…
2/4 "... we discovered that #nucleocapsid #protein shares significant overlap with 22 #multiple #sclerosis (#MS)-associated proteins, including #myelin #proteolipid #protein (#PLP). 

#MultipleSclerosis
3/4 "Further computational evaluation demonstrated that this #overlap may have #critical #implications for #Tcell responses in #multiple #sclerosis (#MS) patients and is likely unique to #SARSCoV2 among the major #human #coronaviruses."
Read 4 tweets
1/4 "Using droplet digital PCR, we found #SARSCoV2 #nucleocapsid #RNA in 7 out of 9 #adenoid and 15 out of 22 tonsil formalin-fixed, paraffin-embedded tissue blocks from post-COV individuals, despite #negative #nasopharyngeal swab #PCRs at the time of surgery..."

#pediatric
2/4 "... variation in memory B cell frequencies and serum-neutralizing antibody titers we observed further highlighted heterogeneity of responses that may leave some #children prone to #repeat #infection."

#pediatric #viral #persistence despite #negative #nasopharyngeal #PCR
3/4 "... activated cells in these #tissues after infection may also contribute to delayed or #prolonged #sequelae of #COVID19, including long-COVID-19 and #multisystem #inflammatory syndrome in children,..."

#LongCovidKids #PASC
Read 4 tweets
The interior of a single virus particle  contains a dense assembly of #ribonucleoproteins (RNPs) that package the genome to form the #nucleocapsid (protein shell of a virus). Notable, it has a cylindrical shape that matches the particle geometry. 1/10
nature.com/articles/s4200…
However, many peope have not understood that these viruses do not #spread exponentially, but in waves (fairy tale of #exponential #growth). 2/10
In this regard, Farr's Law should be mentioned (William #Farr on patterns of #epidemic events), which was banned from the German #wikipedia at the time, but could still be read in the English wikipedia. In the meantime it has marginally reappeared. 3/10
oxfordbrazilebm.com/index.php/covi…
Read 10 tweets
Let’s shift our focus from Spike to #Nucleocapsid protein!

A new study demonstrates that genetic mutations outside the Spike are also key components in #SARS2 continued adaptation to human infection.

1/
The #R203K-#G204R mutation is sufficient to enhance replication, fitness, & pathogenesis of #SARS2. Importantly, the R203K-G204R mutation increases #nucleocapsid phosphorylation, providing a molecular basis for these phenotypes.
2/
Notably, an analogous #alanine substitution mutant also increases #SARS2 fitness and phosphorylation, suggesting that infection is enhanced through ablation of the ancestral ‘RG’ motif. A new Preprint by @TheMenacheryLab 👇
3/

biorxiv.org/content/10.110…
Read 3 tweets
Do children produce different types of #antibodies(Abs) against #SARSCoV2 than adults? 1/ Image
Yes, children mostly produced Abs aimed at #Spike protein, which the virus uses to enter cells. Adults generate similar Abs, but also develop Abs against the #Nucleocapsid protein, which is essential for viral replication 2/

pubmed.ncbi.nlm.nih.gov/33154590/
#Nucleocapsid protein is typically released in significant quantities only when a virus is widespread in the body.
What does it mean? The kids lacked nucleocapsid-specific Abs, which suggests that they aren’t experiencing widespread infection. 3/
Read 8 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!