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#ASCO20 Poster 9586 describes CNS outcomes with osimertinib 160mg for #EGFR NSCLC. Included patients with CNS PD on 80mg who escalated to 160mg (A), concurrent osi 160 with chemo or RT (B) and those who started at 160mg with CNS disease (C). Osi at 160mg was well tolerated. #LCSM 
#ASCO20 median duration of CNS control shown below. In those who had CNS PD and escalated, median was 3.8m but different for parenchymal only (2m) vs leptomeningeal (5.8m). Curious if parenchymal disease was previously radiated pre-escalation. #OncoAler #LCSM #EGFR
#ASCO20 Multicenter effort with valuable real-world evidence by @ZPiotrowskaMD @Jbauml @HwakeleeMD @JoelNealMD @LeciaSequist @RamalingamMD @HelenaYu923 @BeccaHeistMD @HatimHusainMD and more. Pooled RWE will be very valuable going forward, particularly as we examine resistance!
