Discover and read the best of Twitter Threads about #Oncogenetics

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#Oncogenetics Part 3:

This will cover Tumor Suppressor and Onco-Genes.
1/ Now we covered the DNA repair genes that validate the integrity of the DNA, we can look at the growth pathway genes that move the cell through the growth cycle into mitosis.
2/ There are two sets of genes with the Tumor Suppressor Genes and the Proto Oncogenes. The tumor suppressors act like the breaks. They are there to prevent the cell from moving through the cycle until they get a signal to allow it to do so.
Read 21 tweets
#Oncogenetics Part 2:

Genomic Instability.
1/ When it comes to cancer genetics, I am sure we have all heard of Onco-genes or Tumor Suppressor genes. There is another set of critical genes in controlling cancer that most people haven't really heard about.
2/ These are the genes that control the many proteins and enzymes that regulate the integrity of the DNA itself.
Read 16 tweets
#Oncogenetics Part 1:

This will be an introduction with the biology of oncology. Then I plan to get into the genetics. I will then come back and do a walkthrough example of how genetics drive the development of a tumor.
1/ Cancer doesn't start with just 1 mutation. It is an accumulation of mutations over time. It starts with just one cell that develops a mutation which gives it an advantage to grow.
2/ That cell replicates faster than other cells around it or it replicates when its not supposed to. As it continues to divide, it will eventually gain more beneficial mutations which move it down the path toward cancer.
Read 22 tweets

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