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#SARS2 can readily alter its Spike protein via a single Amino acid substitution so that it is not recognized by CD8 T cells targeting the most prevalent epitope in Spike restricted by the most common HLA-I across the population. 1/
The Spike #P272L mutation that has arisen in at least 112 different #SARS2 lineages to date, including in lineages classified as “VOC”, was not recognized by the large CD8 T cell 2/ 
The CD8 T cells response seen across cohorts of HLA A∗02+ convalescent patients & individuals vaccinated against SARS2, despite these responses comprising of over 175 different individual T cell receptors. 3/
