Discover and read the best of Twitter Threads about #P681R

Most recents (4)

Will the newly identified sub-lineages of #Delta may initiate a new wave of #Covid19 in India? What impact the increasing prevalence of the Delta-D clade would have on global #COVID burden?

My write-up deliberating on these issues in @TheWireScience 👇…
#Delta variant and its extended family: How much do we need to worry?

During the first few months of the #pandemic, the evolution of the virus was relatively predictable, with substitutions accumulating at a fixed pace: 1 substitution every second week 2/
In contrast, the 2nd year of the #pandemic is punctuated by the emergence of several #variants that bore evidence of dramatic evolution 3/
Read 40 tweets
The 2nd preprint from G2P-Japan is out at @biorxivpreprint !
We revealed that the SARS-CoV-2 delta variant (B.1.617.2 lineage) is highly fusogenic and #P681R mutation, a hallmark in the B.1.617 lineage, is its determinant. Please retweet 1/3…
In this study, we demonstrated that #P681R mutation in the SARS-CoV-2 spike protein enhances and further accelerates SARS-CoV-2 spike-mediated cell-cell fusion. 2/3
Photo: Syncytia formed by SARS-CoV-2 infection in VeroE6/TMPRSS2 cells. Note that B.1.617.2 is the delta variant, and B.1.617.1 is a variant emerged in India. B.1.1 is a prototype. Referred from Figure 2B of our preprint. 3/3
Read 3 tweets
当研究室が主宰する新型コロナ研究コンソーシアム「G2P-Japan」のプレプリント第2弾を、@biorxivpreprint に発表しました。
本研究ではまず、 #デルタ株 (通称 #インド株 、B.1.617.2系統)に感染した細胞が、周囲の細胞と「くっつきやすい」ことを明らかにしました。 1/4…
そしてその「くっつきやすさ」が、 #P681R 変異という、デルタ株特有のスパイクタンパク質の変異によって引き起こされることを明らかにしました。 2/4
↓は、プレプリントからの抜粋・改変した、新型コロナに感染した細胞の写真。従来株(B.1.1系統)に比べて、 #インド株 (B.1.617.1とB.1.617.2系統)に感染した細胞は周囲の細胞と「くっつきやすく」、より大きな細胞塊を形成します(G2P-Japanメンバー、清水健太博士@北海道大学が撮影・提供)。 3/4
Read 4 tweets
Convergent evolution of #SARS_CoV_2 spike mutations, #L452R, #E484Q and #P681R, in the second wave of #COVID_19 in Maharashtra, #India | bioRxiv
„newly identified lineage B.1.617 possessing common signature mutations D111D, G142D, L452R, E484Q, D614G and P681R, in the spike protein including within the receptor binding domain (RBD)“
„The structural analysis of RBD mutations L452R and E484Q along with P681R in the furin cleavage site, may possibly result in increased ACE2 binding and rate of S1-S2 cleavage resulting in better transmissibility.“
Read 5 tweets

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