Discover and read the best of Twitter Threads about #PACs
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#Maraviroc #Pravastatin ⚠️
🧵 Summary of a promising study (published Feb 2023) for #LongCovid / #PACS (in German and English) ❗️
🧵 Zusammenfassung einer vielversprechenden Studie(erschienen Feb 2023) für LongCovid / #PACS (in German and English) ❗️
ncbi.nlm.nih.gov/pmc/articles/P…
🧵 Summary of a promising study (published Feb 2023) for #LongCovid / #PACS (in German and English) ❗️
🧵 Zusammenfassung einer vielversprechenden Studie(erschienen Feb 2023) für LongCovid / #PACS (in German and English) ❗️
ncbi.nlm.nih.gov/pmc/articles/P…
Maraviroc, ein zugelassenes HIV Medikament, setzt bei den CD16+ Monozyten an, die sowohl CCR5 /RANTES als auch Fraktalkinrezeptoren (CX3CR1) exprimieren, und fähig sind die Blut-Hirn-Schranke zu passieren (ZNS-gängig sind).
Maraviroc, a potential HIV therapeutic, affects CD16+ monocytes, which express both CCR5 and fractalkine receptors (CX3CR1). This kind of cells can pass the blood-brain-barrier and therefore can affect the Central Nervous System.
VENOUS BLOOD GASES (VBG)
In addition to
LongCOVID
Post Vax
They are useful in
ME/CFS
Fibromyalgia
POTS
Lyme
EBV
Bartonella
Arthritis
Sjögren's
Lupus
Ehlers-Danlos
Restless Legs
Fasciculations
Stiff Person
Adrenal Fatigue
Thyroiditis
Mitochondrial Dysfunct.
researchgate.net/publication/35…
In addition to
LongCOVID
Post Vax
They are useful in
ME/CFS
Fibromyalgia
POTS
Lyme
EBV
Bartonella
Arthritis
Sjögren's
Lupus
Ehlers-Danlos
Restless Legs
Fasciculations
Stiff Person
Adrenal Fatigue
Thyroiditis
Mitochondrial Dysfunct.
researchgate.net/publication/35…
INVERSE CORRELATION WITH MICROCLOTS
We observed that
the lower the value resulting from the
Venous Oxygen Saturation: SvO2
There is a greater amount of #Microclots
and a greater improvement is obtained when giving treatment with
Antiplatelet
Fibrinolytics
Drugs against Viral Load
We observed that
the lower the value resulting from the
Venous Oxygen Saturation: SvO2
There is a greater amount of #Microclots
and a greater improvement is obtained when giving treatment with
Antiplatelet
Fibrinolytics
Drugs against Viral Load
Venous Blood Gases: VBG
it is a low cost blood test:$18-40
It can be performed in most Hospitals in the world
The results can be given in a few hours
In Australia can be ordered by any GP under Medicare
And why is it still not used in North America/Europe?
it is a low cost blood test:$18-40
It can be performed in most Hospitals in the world
The results can be given in a few hours
In Australia can be ordered by any GP under Medicare
And why is it still not used in North America/Europe?
In this study
in addition to reporting the longest persistent infection to date:
505days
They describe a case that they call
‘Occult’ infection
It is a case that gave Negative in its PCR several times
and developed COVID symptoms again after several months
in addition to reporting the longest persistent infection to date:
505days
They describe a case that they call
‘Occult’ infection
It is a case that gave Negative in its PCR several times
and developed COVID symptoms again after several months
In this case
sequencing of the virus genome showed that infection
was caused by the Alpha variant
which had already been removed from the UK by that date
indicating that the virus had persisted latent in the patient for several months
and the PCRtests did not detect it
#LongCOVID
sequencing of the virus genome showed that infection
was caused by the Alpha variant
which had already been removed from the UK by that date
indicating that the virus had persisted latent in the patient for several months
and the PCRtests did not detect it
#LongCOVID
Very often PCR of nasal and pharyngeal secretions
they give False Negatives in #LongCOVID #PACS
The problem is that most assume that a Negative PCR of the nose or pharynx
Indicates that there is no virus in the heart, intestines and other parts of the body
they give False Negatives in #LongCOVID #PACS
The problem is that most assume that a Negative PCR of the nose or pharynx
Indicates that there is no virus in the heart, intestines and other parts of the body
UNDIAGNOSED VIRAL PERSISTENCE
IN 32.5% OF PATIENTS UNDERGOING BARIATRIC SURGERY
All had Negative PCR before Surgery
They were unaware they had a Persistent Infection due to SARS-CoV-2
One part had more than 1 year since infection
doi.org/10.1007/s11695…
Are #UndiagnosedLongCOVID
IN 32.5% OF PATIENTS UNDERGOING BARIATRIC SURGERY
All had Negative PCR before Surgery
They were unaware they had a Persistent Infection due to SARS-CoV-2
One part had more than 1 year since infection
doi.org/10.1007/s11695…
Are #UndiagnosedLongCOVID
100% of the PCR tests were False Negatives
If the infection persists
the virus will no longer be found in secretions from the nose & throat
It is located inside the cells
Viruses cause Intracellular Infections
PCR cell/tissue samples required in #LongCOVID
researchgate.net/publication/34…
If the infection persists
the virus will no longer be found in secretions from the nose & throat
It is located inside the cells
Viruses cause Intracellular Infections
PCR cell/tissue samples required in #LongCOVID
researchgate.net/publication/34…
The patients operated on in whom it was performed
the finding of
undiagnosed persistent infection
had on average 274 days from the onset of SARS CoV-2 infection
and surgery
61.5% were vaccinated (>2 doses Pfizer)
No differences were identified between vaccinated and unvaccinated
the finding of
undiagnosed persistent infection
had on average 274 days from the onset of SARS CoV-2 infection
and surgery
61.5% were vaccinated (>2 doses Pfizer)
No differences were identified between vaccinated and unvaccinated
VIRAL PERSISTENCE
IT IS THE MAIN CAUSE OF MYOCARDITIS IN #LONGCOVID
In 85.7%(12/14) of Endomyocardial Biopsies
persistence of up to 18 months of SARS CoV2 was detected
It was identified in Cardiomyocytes,Endothelium,Macrophages
Also Anticardiac Antibodies
onlinelibrary.wiley.com/doi/10.1002/cl…
IT IS THE MAIN CAUSE OF MYOCARDITIS IN #LONGCOVID
In 85.7%(12/14) of Endomyocardial Biopsies
persistence of up to 18 months of SARS CoV2 was detected
It was identified in Cardiomyocytes,Endothelium,Macrophages
Also Anticardiac Antibodies
onlinelibrary.wiley.com/doi/10.1002/cl…
None of the 14 cases had severe respiratory failure or evidence of cardiac injury during Acute COVID
In all of them Myocarditis only manifested itself after the acute phase of COVID
In #LongCOVID #PACS
This was diagnosed 2 to 18 months later
and confirmed by Endomyocardial Biopsy
In all of them Myocarditis only manifested itself after the acute phase of COVID
In #LongCOVID #PACS
This was diagnosed 2 to 18 months later
and confirmed by Endomyocardial Biopsy
In 2of the cases
47year-o. women
Myocarditis symptoms appeared only after vaccination
this means
who were carriers of a latent infection
Authors point out:
This suggests a triggering (resolving) role of the vaccine
when administered after an infection
that can remain asymptomatic
47year-o. women
Myocarditis symptoms appeared only after vaccination
this means
who were carriers of a latent infection
Authors point out:
This suggests a triggering (resolving) role of the vaccine
when administered after an infection
that can remain asymptomatic
PAXLOVID versus TRUVADA
FOR CHRONIC COVID #LONGCOVID #PACS
For costs and side effects
and as months of treatment are required
Win Truvada
containing
Emtricitabine FTC+
Tenofovir Disoproxil FumarateTDF
One could start with Paxlovid and continue with Truvada
FOR CHRONIC COVID #LONGCOVID #PACS
For costs and side effects
and as months of treatment are required
Win Truvada
containing
Emtricitabine FTC+
Tenofovir Disoproxil FumarateTDF
One could start with Paxlovid and continue with Truvada
PROTOCOLS FOR CHRONIC COVID #LONGCOVID
I. INTENSIVE PHASE AGAINST VIRAL LOAD
It includes:
1.FTC/TDF (Truvada). The alternative is to start Paxlovid for 10-25 days and then continue with FTC/TDF
2. IVM or Liposomal Artemisinin or Artesunate
3. ECGC or Nitazoxanide or Ozone 10pass
I. INTENSIVE PHASE AGAINST VIRAL LOAD
It includes:
1.FTC/TDF (Truvada). The alternative is to start Paxlovid for 10-25 days and then continue with FTC/TDF
2. IVM or Liposomal Artemisinin or Artesunate
3. ECGC or Nitazoxanide or Ozone 10pass
The objective of the INTENSIVE PHASE in CHRONIC COVID #LONGCOVID
is to minimize the Viral Load
Lasts 1-2months
Then follows the Maintenance Phase
whose objective is to avoid the Relapse/Reactivation of the infection
The number of drugs is reduced
Lasts 3 to 8months
depending
case
is to minimize the Viral Load
Lasts 1-2months
Then follows the Maintenance Phase
whose objective is to avoid the Relapse/Reactivation of the infection
The number of drugs is reduced
Lasts 3 to 8months
depending
case
ASYMPTOMATIC OR LATENT PERSISTENT INFECTION IN CHILDREN.
SARS COV-2 WAS DETECTED IN BIOPSIES OF TONSILS OR ADENOIDS
IN 25% OF ASYMPTOMATIC CHILDREN
None had experienced signs or symptoms
Authors point out:
lymphoid tissue may be a Reservoir of SARS-CoV-2
doi.org/10.1016/j.bjor…
SARS COV-2 WAS DETECTED IN BIOPSIES OF TONSILS OR ADENOIDS
IN 25% OF ASYMPTOMATIC CHILDREN
None had experienced signs or symptoms
Authors point out:
lymphoid tissue may be a Reservoir of SARS-CoV-2
doi.org/10.1016/j.bjor…
It had already been identified that the Biofilm or Dental Plaque harbors SARS CoV-2
To this is added the Tonsils and Adenoids in children
Therefore, it is confirmed that the oral cavity is a potential reservoir for the virus
There are Asymptomatic Carriers
To this is added the Tonsils and Adenoids in children
Therefore, it is confirmed that the oral cavity is a potential reservoir for the virus
There are Asymptomatic Carriers
In #LongCOVID
For Viral Persistence,
for having Drug-Resistance
we indicate 3 or more medications or supplements with effects against Viral Load
In addition
any infectious focus at the oral level must be eliminated by the Dentist
and mouthwash is indicated
For Viral Persistence,
for having Drug-Resistance
we indicate 3 or more medications or supplements with effects against Viral Load
In addition
any infectious focus at the oral level must be eliminated by the Dentist
and mouthwash is indicated
#Covid #LongCovid
Vacunados y no vacunados presentan resultados prácticamente idénticos frente al #PACS.
¿Que es PACS?
Es el nombre técnico del Covid Persistente.
>>
ijidonline.com/article/S1201-…
Vacunados y no vacunados presentan resultados prácticamente idénticos frente al #PACS.
¿Que es PACS?
Es el nombre técnico del Covid Persistente.
>>
ijidonline.com/article/S1201-…
¿La vacuna no sirve?
Reduce la probabilidad de tener PACS, pero si te dá, no reduce sus efectos.
¿Eso me afecta?
Afecta a todos. Luego de tener COVID, ya sea leve, asintomático o grave, parte de los contagiados desarrollarán PACS. Esto afecta a todos los órganos.
>>
Reduce la probabilidad de tener PACS, pero si te dá, no reduce sus efectos.
¿Eso me afecta?
Afecta a todos. Luego de tener COVID, ya sea leve, asintomático o grave, parte de los contagiados desarrollarán PACS. Esto afecta a todos los órganos.
>>
¿Después de que ya se me pasó?
Si. Despues. Restos del virus pueden permanecer meses en el cuerpo causando daño en todos los órganos, más notoriamente en el cerebro.
¿Como qué?
Puede ser tan leve como pérdida de concentración o tan grave como gatillar parkinson's
>>
Si. Despues. Restos del virus pueden permanecer meses en el cuerpo causando daño en todos los órganos, más notoriamente en el cerebro.
¿Como qué?
Puede ser tan leve como pérdida de concentración o tan grave como gatillar parkinson's
>>
A very poignant and timely question from Alan Cantwell Jr, MD.
"Is the point to cure the disease—or to keep the research in the hands of a few men who can command huge amounts of Congressional funding?"
#LongCovid #PACS
"Is the point to cure the disease—or to keep the research in the hands of a few men who can command huge amounts of Congressional funding?"
#LongCovid #PACS
"..in order to assure research dollars, scientists have to keep a proper face on their efforts. They can't admit weakness, uncertainty. They have to forge ahead with their virus and their plans for a vaccine, a magic bullet that will wipe the problem off the face of the earth."
"Ask ten scientists about the chances of AIDS originating by accident in a lab. ..and ten will scoff at you. 'Why, how perfectly crude of you to suggest such a thing. How absurd. Only an uneducated non-Ph.D. without a credential to his name would suggest such tripe.'"
@Pfizer @POTUS @TheDemocrats @VP @CNN @CBSNews @NBCNews @WKRN @WSMV @NC5
#Paxlovid #LongCovid #PACS #ProteaseInhibitor #Its2022FFS #WeDeserveBetter #DrugRepurposing
#Paxlovid #LongCovid #PACS #ProteaseInhibitor #Its2022FFS #WeDeserveBetter #DrugRepurposing
@pfizer @POTUS @TheDemocrats @VP @CNN @CBSNews @NBCNews @WKRN @WSMV @NC5 I have had the amazing opportunity to sit on Vanderbilt's HIV/AIDS Clinical Trials Community Advisory board since 2015 and want to shine a bright light on how therapeutics with SARS-Cov-2 should have been managed in the same way as HIV.
@pfizer @POTUS @TheDemocrats @VP @CNN @CBSNews @NBCNews @WKRN @WSMV @NC5 During the early years of the HIV/AIDS crisis, many were without any options. Then, AZT and other handfuls of medications were made available. Those who took it were literally guinea pigs. While supposition, I imagine escaping hospitalization and death were the metrics used.
And the road to @MICCAI_Society @MiccaiS #Singapore has started! Cannot wait to present #ImagineQuant @YaleRadiology #BrainLesWorkshop 20 hrs travel totally worth it 😅😎❤️ to learn from the best #MICCAI22. @ujjwalbaid0408 @SpyridonBakas
#BrainLesWorkshop @MICCAI_Society @MiccaiStudents @WomenInMICCAI #ClinicalTranslation of #ML, #PACS based ML, #Neuroradiology, #GBM, Asking questions that address #radiologists & #oncologists real clinical needs! 🎊🦄🎉 #Industry #Collab @MingDeLin1234 brainlesion-workshop.org
Goodbye #Newark #NYC, looking forward to #Tokyo in 12 hrs! Dreams do come true!!! #academiclife #neurorad Thinking of @hsairmd @sairaallapeikko @theASFNR #Maui just about now! Will have to finish that episode 13 soon! @MICCAI_Society @MiccaiStudents @WomenInMICCAI #ImagineQuant
Machine Learning Tools for Image-Based Glioma Grading and the Quality of Their Reporting: Challenges and Opportunities mdpi.com/1648502 #mdpicancers via @Cancers_MDPI @YaleRadiology
@MerkajSara @Ryan_Bahar are an outstanding team that wrote this exciting review on application of #ML to the study of #glioma imaging. After reviewing over 12,000 articles and extracting information from over 80 articles they published their systematic review in @FrontOncology.
But, there was so much more that needed to be discussed, so @MerkajSara & @Ryan_Bahar wrote an expert review of literature with focus on future directions. @YaleMed #Neurosurgery This review is a must read when starting out in #ML & #glioma imaging #Radiomics overview
'Endemic Delusion' in Denmark - coming to a continent / country / city / town / village / house near you, if it isn't already in your living-room.
#FarFromNormal
#P100
#ElastomericBulletproof
Q & A.
Not sure why anyone would focus on one particular continent when this happens to be a global pandemic.
When Pi?
#ButtonUp #N95 #FFP3 #GoElastomeric #P100
This is how it's done. Humanity at work, finally.
Italy gets it.
#MasksInSchools #MasksSaveLives #MasksSaveBrainDamage
The Council for National Policy #CNP, "The Secret Society"
web.archive.org/web/2012102019…
"the heart of a great conservative movement that helped to make America strong and prosperous in the 20th century – now helping to ensure she remains free and secure in the 21st century,"
web.archive.org/web/2012102019…
"the heart of a great conservative movement that helped to make America strong and prosperous in the 20th century – now helping to ensure she remains free and secure in the 21st century,"
Some CNP members - Mike Pence comes quickly to mind - in the context of bolstering their conservative credentials, have proudly revealed their CNP membership, even though CNP's policy is to keep membership a secret. Here is it's 2014 Membership, the latest splcenter.org/sites/default/…
#CNP's tentacles include well-connected activists who advocate for the imposition of fundamentalist Christian ideology in public life and have succeeded in forcing their agenda in republican administrations. A list of organizations working with CNP web.archive.org/web/2012020417…
Le #PACS fête ses 20 ans 🎂 ! Les français à l’étranger officialisent leur amour : c’est dans nos consulats à Bruxelles, Sao Paulo, Londres, Montréal et Genève que le plus grand nombre de PACS ont été conclus 👏 #PACS20ans ❤💋
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📸 Jean-Loup Gautreau / AFP
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📸 Jean-Loup Gautreau / AFP
La loi relative au #PACS (pacte civile de solidarité) a été votée le 15 novembre 1999 #PACS20ans
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📸 Eric Federberg / AFP
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📸 Eric Federberg / AFP
Le 30 décembre de la même année, le 1er #PACS est contracté entre un Français et un étranger au consulat de Barcelone #PACS20ans
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📸 Jean-Loup Gautreau / AFP
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📸 Jean-Loup Gautreau / AFP
