Discover and read the best of Twitter Threads about #PAI

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#WeekendLecture
#Tenecteplase #TNK
Part 1
✅3rd generation rtPA
🧬Targeted genetic upgrade
3 specific alterations to #alteplase molecule:
👉⬆️Half life
👉⬆️Binding affinity for #fibrin
👉⬆️Resistance to inactivation by #PAI-1
bit.ly/3pqbEb1 Image
#WeekendLecture
#TNK

👉⬆️T1/2 allows single bolus dosing and⬆️clot exposure to TNK
👉Higher affinity to fibrin-rich clots & + potent/faster clot #lysis vs alteplase
👉 < consumption of fibrinogen/plasminogen/ a2- antiplasmin👉⬇️systemic fibrinolytic effect👉⏬risk for bleeding Image
#WeekendLecture
#TNK
First analysis in stroke patients was a #dose-scalation safety study
There was no #symptomatic ICHs in dosis of 0.1-0.2-0.4mg/kg, and 15% (2 of 13) in 0.5mg/kg
No differences in clinical outcomes
bit.ly/3DNHamV ImageImage
Read 11 tweets
"Em Israel 🇮🇱 acabou a #pandemia, com 70% já vacinados
No fim do #Shabat hoje reabriram os bares para os vacinados! שבת שלום ולחיים

Estão cantando com euforia pela volta da alegria pra Tel-Aviv."
"No #Brasil🇧🇷, a viagem produziu manchetes, memes e análises. Foi parar em todos os jornais, TVs, rádios e sites de notícias, canais do Youtube e, claro, em threads no #Twitter.

Em #Israel🇮🇱? É um desafio encontrar #israelenses que saibam ou se lembrem de ter visto algo sobre...
...essa visita. Certamente, o nível de importância – pública ou diplomática – não pode ser comparado. Infelizmente, na balança dessa ligação internacional, o Brasil não está para Israel como Israel está para o Brasil. 👉🏾🇧🇷💉🇮🇱
Read 26 tweets

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