Discover and read the best of Twitter Threads about #PDAC

Most recents (5)

1. ENTER #mRNAvaccines for #pancreaticcancer! Long-term #PDAC survivor story PART3.

"Do #PDACs REALLY have vaccine neoantigens (NAs)"? (aren’t they lowly mutated?)

If each patient = own NAs, how do you vaccinate?

Maybe mRNA? But how?

@Nature nature.com/articles/s4158…

👇🏽 [1/32]
2. In 2017, we reported in @Nature here -> nature.com/articles/natur… -> that primary tumors of long-term survivors of #PDAC had ~12x more activated CD8 T cells vs. short-term survivors

AND

despite #PDAC’s few mutations, mutation-derived NAs may still be T cell antigens in #PDAC.
3. Now, prevailing belief ->#PDAC = few mutations = fewer mutation-derived NAs = NAs unlikely #PDAC T cell antigens.

BUT...our #NeoantigenQualityModel(estimates the ~1-2% of immunogenic NAs)

found that long term #PDACsurvivors ∝ more “high quality” NAs ∝longer survival. Image
Read 33 tweets
Today, in @Nature, we reveal PART 2 of our investigations on

“What IS going on in long-term survivors of #PancreaticCancer (#PDAC)?”

“Is it REALLY the immune system?”

Well…more evidence here - > nature.com/articles/s4158…

Thread below [1/30]
In 2017, we reported in @Nature here -> nature.com/articles/natur… -> that primary tumors of long-term survivors of #PDAC had ~12x more activated CD8 T cells vs. short-term survivors. Now, others had reported this before - but we wanted to know:

“What are the antigens?” Image
Here, the prevailing belief was:

#PDAC has few mutations -> even fewer mutation-derived neoantigens -> neoantigens are unlikely T cell antigens in #PDAC.

But we thought: despite #PDAC’s few mutations, mutation-derived neoantigens may still be T cell antigens in #PDAC survivors
Read 31 tweets
Really chuffed to share our latest work from Sanjana Lab out in @nature today (nature.com/articles/s4158…).

We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.

A thread...
(2/28) T cell therapies have shown the potential to cure patients from #cancer – but even in B cell cancers, relapses outnumber cures… One of the problems is limited T cell persistence. #celltherapy #CARTcell
(3/28) We wanted to find new genes (including genes never expressed in T cells) that could improve T cell persistence. Now, the question was: should we use #crispr activation or directly deliver target genes on a #lentivirus?
Read 30 tweets
1/8 #TumorBoardTuesday
➡️This week's Thurs Case🎀 is here!

🔬We discussed locally advanced #PancreaticCancer--& sig of germline muts (ATM). @SirohiBhawna takes us on her pt’s treatment journey.

🗝️insights 🤔on locally advanced #PANCAN below!
#PancreaticCancerAwarenessMonth Image
1.5/8 #TumorBoardTuesday

👉👉 Don’t forget to pick up your 🆓 #CME credit by answering 2 quick❓
Here’s the post-test 🔗: bit.ly/3ws480C

ALL CME 🔗: integrityce.com/tbt Now...on to the case!
2/8 #TumorBoardTuesday
Thurs Case🎀
11/09/2021
Take🏠:

✅Upfront tx depends on pt- mFFX vs gem/nab-pac
✅Test all #PDAC for germline mut regardless of FH!‼️
✅Screen w annual MRI/EUS in gATM
✅Emerging 💊combos tx ATM-mut
#PANCAN req multi-D- role for palliative SBRT, ?IRE
Read 12 tweets
#TumorBoardTuesday
💥Wow - this week was TOO much‼️

A🗣️on TMB-high #PancreaticCancer & #Immunotherapy by @DrBonillaOnc

AND our 1st pt-directed🗣️led by @HPolymenis and @StephenVLiu

👉Don’t forget your🆓#CME credit-answer 3 quick❓
Here's the postest🔗
surveymonkey.com/r/6JVHCSG Image
#TumorBoardTuesday
Thursday Case🎀
(Case from 06/01 and 06/02/21)

We discussed #PancreaticCancer and:
✅Cynicism/Nihilism
✅The importance of multi-D care
✅1st line Tx
✅🧬Testing
#Immunotherapy

We captured as much as we could in this moment:
twitter.com/i/events/13999…
#TumorBoardTuesday
Thursday Case🎀
(Case from 06/01 and 06/02/21)

And also this moment:
twitter.com/i/events/14005…
Read 20 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!