Discover and read the best of Twitter Threads about #PDB
Most recents (12)
#Bioinformatics is playing an increasingly important role in the discovery and development of new #drugs. In this thread, we'll explore how #bioinformatics is being used to identify new targets for drug intervention and optimize drug design.
One key aspect of #bioinformatics in drug discovery is the identification of potential #drug #targets.
š§µ#Bioinformatics and its impact on #healthcare, a THREADš§µš§µ:
#Bioinformatics is the application of #computational techniques to the analysis of #biological data, such as #DNA sequences and #protein #structures.
In #healthcare, #bioinformatics is used to gain insights into the #genetic basis of diseases, and to develop new #diagnostic tests and #treatments.
Examples from our Protein Common Assembly Db now on @biorxiv_bioinfo with @QifangXu. Viable assemblies for all Xray structures (EPPIC, @josemduarte), clustered w/ cryoEM, NMR assemblies by Pfam architectures + stoichiometry+ symmetry + interfaces. @buildmodels @PDBeurope @pdbj_en 
We count "Crystal forms (CFs)" - unique crystal unit cells or cryo-EM or NMR experiments for each cluster, and number of uniprot sequences across each cluster. More experimental data --> more support for relevance of biological assembly. Also #PDB's bioassemblies, PISA, EPPIC.
PCNA example from 1st tweet. Largest cluster (#8) of Pfam arch (PCNA_N)_(PCNA_C) has 28 crystal forms (CFs) out of 36 CFs for this Pfam architecture in whole in PDB (78%). 19 UNPs of 23 in whole PDB (83%). 55 entries of 64 in whole PDB (86%).
dunbrack2.fccc.edu/ProtCAD/Resultā¦
dunbrack2.fccc.edu/ProtCAD/Resultā¦
.@PressSec starts of briefing says neither the front page of the @nytimes nor the White House podium is a venue "for discussing classified information"
"We are here having this discussion today because of an irresponsible, anonymous leak"
"We are here having this discussion today because of an irresponsible, anonymous leak"
"There is no good scenario as a result of this New York Times report" per @PressSec
"Who's going to want to cooperate w/the United States intelligence community? Who's going to want to be a source or an asset if they know that their identity could be disclosed"
"Who's going to want to cooperate w/the United States intelligence community? Who's going to want to be a source or an asset if they know that their identity could be disclosed"
#MDSI2019 Day2 Session 2: "Standardization of file format I/O" by @jppiquem.
Straight into problems -- input files are a tougher cookie to crack than output šŖ
Straight into problems -- input files are a tougher cookie to crack than output šŖ
Actually, Day 2 Session 3 #hasphdcantcount
#Input: Many problems -- many possible solutions! How to find the right one? #goldilocks
#Output: probably easier to handle and we can learn from other fields, like climate research.
#Output: probably easier to handle and we can learn from other fields, like climate research.
1/ #Django will use watchman to do autoreload if it's installed since 2.2. The default reloader runs stat on all the files in your project once per second, whereas watchman will use os file system events, which is much more efficient.
2/ I never cared about this until I spent an afternoon figuring out why Docker for Mac's hyperkit process sits on 120% - 150% cpu use while running my mid sized django project in a container.
3/ i used 'docker stats' to deduce which container, then 'top' and 'ps auxf' to work out which python process was the problem. Then did a thread dump of the django server using faulthandler.dump_traceback() triggered from an API call, and then 'docker log'
The campaign news is all about the Benjamins today with breakdowns of the Q2 totals in the news. @PeteButtigieg is in Kansas City for a Grassroots Event at 7pm. Here's today's #PDB:
.@nytimes analyzes fundraising numbers: nytimes.com/2019/07/16/us/ā¦
.@PeteButtigieg had a successful weekend campaigning in New Hampshire and Iowa. He's in South Bend today doing mayor stuff such as opening a new firehouse. Here's the #PDB:
If youāve ever wondered why one of the most secretive organizations in the world is committed to #transparency, or how we go about protecting Americanās privacy & civil liberties, keep reading.
bit.ly/2Wne9JO
bit.ly/2Wne9JO
Ben Huebner runs CIAās Privacy & Civil Liberties Office.
His job is to look at our programs & practices to make sure weāre living up to our commitment to safeguard Americanās privacy & civil liberties.
Heās also leading CIAās efforts to increase #transparency.
His job is to look at our programs & practices to make sure weāre living up to our commitment to safeguard Americanās privacy & civil liberties.
Heās also leading CIAās efforts to increase #transparency.
CIAās mission & the safety of the men & women who contribute to it will always require certain information to be #classified.
The key is there needs to be a real, identifiable, justifiable reason why that fact, that method, or that source needs to remain secret.
The key is there needs to be a real, identifiable, justifiable reason why that fact, that method, or that source needs to remain secret.
#PDB is primary vehicle for summarizing day-to-day sensitive intel & analysis for @WhiteHouse on current & future national security issues.
Style, format & presentation of #PDB are based on preferences of @POTUS. Mr. Obama asked for it electronically.
Mr. Nixon, once practicing attorney, liked to review #PDB on long legal size paper. This format was carried into the Ford administration.
24 AUG: Declassified Nixon & Ford PDBs to be released @ event held @NixonLibrary
bit.ly/2b5bZpN
CC: @Ford_Library
#PDB
bit.ly/2b5bZpN
CC: @Ford_Library
#PDB
Nixon & Ford PDBs to be released @ symposium entitled āThe Presidentās Daily Brief: Delivering Intelligence to Nixon and Ford.ā
#PDB
#PDB
April 1996: James M. Lewek was killed in a plane crash near Dubrovnik, Croatia.
#inmemoriam
1.usa.gov/1qV0o4j
#inmemoriam
1.usa.gov/1qV0o4j
Jim a native of Cheektowaga, NY held a BA in Econ from @Cornell & completed course work for a PhD in Econ from @VanderbiltU.
#inmemoriam
#inmemoriam
1975: Jim joined CIA & learned craft of economic intel analysis by working on some of the most formidable hard-target countries.
#inmemoriam
#inmemoriam
