Discover and read the best of Twitter Threads about #PID

Most recents (7)

Para aprender o que é um processo em Elixir, antes você tem que saber o que é uma função.

Por exemplo, IO.puts/1 é uma função que escreve algo na tela. A função se chama puts, ela está no módulo IO (de entrada I e saída O) e ela recebe um argumento:
iex(1)> IO.puts("Adolfo")
Adolfo
:ok

Se tudo dá certo ela retorna o átomo :ok.
Uma função que te permite gerar (tradução talvez imprecisa de spawn, em inglês) é Kernel.spawn/1.

Novamente, o nome dela é spawn, ela faz parte do módulo Kernel e recebe um argumento.
Read 18 tweets
Ich fasse mal die Lage in #Deutschland zusammen.
Der #Scholzomat stellt sich ausgerechnet vor #AnneSpiegel, als sie kurz danach einen Termin mit der Spitze der #grüne​n #VollkornCDU hat; aus dem ihr Rücktritt, den @nouripour als "richtig" beschreibt, folgt.
1/? #Piraten
Der #Scholzomat selbst wird kurz nach dem 24. Feber 2022 (#Ukraine) in einer PK mit @JoeBiden vorgeführt, als er versucht sich aus, Bidens Erklärung, #NordStream2 werde nach dem Überfall nicht fertiggestellt, rauszuwinden. (Oder war das kurz vor der #Ukraine?)
2/? #Piraten
* #Lambrecht als @BMVg_Bundeswehr kommt als dritte Frau in das Amt, d.h. sie wird nach dem Einarbeiten der Vorgängerinnen bewertet. Über ihren schlechten Führungsstil wird berichtet. Der #Scholzomat muß einschreiten.
3/? #Piraten
Read 14 tweets
#LongCOVID

We reviewed 14 studies of persisting symptoms following #COVID19 in #children & #adolescents

Most had major limitations and should be interpreted with caution.

True risk is likely to be nearer 1 in 100 than often quoted 1 in 7.

#medpeds #IDTwitter

(Long) 🧵1/n
The 14 studies involved 19,426 children & adolescents.

Common persistent symptoms reported 4-12 weeks after acute #COVID19 were:

•headache
•fatigue
•sleep disturbance
•concentration difficulties
•abdominal pain.

Symptoms rarely lasted more than 12 weeks.
Read 13 tweets
To reassure parents, a reminder of some key facts about #COVID in #children:
 
#SARSCoV2 infection remains asymptomatic or mild in the vast majority of children, even with the #DeltaVariant. Hospitalisation and deaths from COVID are still rare in this age group.

1/n 🧵
However, the greater transmissibility of the Delta variant means there is more COVID in *all* age groups, including children, so we will see more paediatric cases.
As a large number of older people are now vaccinated, the increase is blunted in the elderly so, compared with earlier in the pandemic, a higher *proportion* of current cases will be in children: this can give the mistaken impression that the Delta variant is targeting children.
Read 7 tweets
We have an exciting new #preprint on @medrxivpreprint ! A novel class of #primaryimmunodeficiency, with the discovery of ITPR3 mutations in two families with combined immunodeficiency. As always, studying #PID teaches us so much about biology! 1/8

medrxiv.org/content/10.110…
The work is based on patients identified @UZLeuven by Rik Schrijvers and @IsabelleMeyts. Both patients had a combined #immunodeficiency with sensitivity to infections, one complicated by peripheral #neuropathy and one by #autoimmune hemolytic anemia. Over to the gene hunters! 2/8
Mutations in ITPR3 were identified by Erika Van Nieuwenhove and Frederik Staels. ITPR3 is part of a #Calcium channel, so we turned to the Serysheva lab @Irina52948708 to predict the impact on structure. Clear as day, the mutations change the charge of the channel. 3/8
Read 8 tweets
🤔...Tonight I am wondering:

Do the lives of #rarediseases #PID patients matter as much as the lives of patients affected by more 'common' conditions such as #COVID__19 ?

Answer=YES
Does #plasma save lives?

Answer= YES
#hyperimmuneglobulins derived from plasma are under development and potentially could save the lives of people with severe forms of #COVID19. Isn't this great?

Answer= Yes!
Read 10 tweets
Just floating an idea about #PID and #FAIR that has been in back of my mind for some time. In the blockchain world, @IpfSbot creates PIDs or addresses (#multihash) based on the content of the digital object. Wouldn't it be great if the scientific community embraced this pattern?
A little bit of context: creating PIDs for your digital assets is the first #FAIR principle (F1) and an absolute cornerstone for rolling out #datastrategy. This is typically solved in the scientific world by creating handles through a party that guarantees persistence, e.g. #DOI.
Independently, I have been following #IPFS (ipfs.io) #opensource community over the last few years who have a really interesting architecture for the decentralized internet. It's a mix of #git like merkle trees, p2p technology (like bittorrent), and crypto hashes.
Read 12 tweets

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