Discover and read the best of Twitter Threads about #PTEN

Most recents (2)

Unido al hilo de Luís sobre la diferenciación de los #macrófagos (M), he considerado oportuno aportar diferentes ESTRATEGIAS NO FARMACOLÓGICAS para hackear la entrada de #glucosa en la célula y evitar su proliferación.

Dentro hilo #inmunometabolismo ⬇️
1️⃣ Inhibir #PDK-1.

Como no quiero aportar fármacos para ello, tocaría saltármela.

¿Cómo? Fácil, cambiando de sustrato. La glucosa pasa por ella. La grasa, no.

PDK-1 es clave en el metabolismo de la glucosa y en la diferenciación de los M. Su caída disminuye M1 y aumenta M2.
En la #mitocondria es el lugar donde se generan los estímulos apópticos.

El daño mitocondrial (metabolismo ineficiente) precede a las neoplasias y estimulan la autoinmunidad.

Aportar nutrientes que estabilicen la biogenesis mitocondrial será clave.
Read 9 tweets
Folks! We return for #HOTrainees with the exciting #Day2 @myESMO #ESMO20 and some more #practice relevant studies in #breastcancer #ProstateCancer #lungcancer #GI, so sit back, relax and lets go through some data (#HO #trainee-style!) Shout out to @peters_solange @OncoAlert
1. #BreastCancer: We have #monarchE and #IMPassion031 hoping to hear from experts @ErikaHamilton9 @NicoleKuderer @DrSGraff @matteolambe @tmprowell @GeorgeSledge51 @VukovicPetra for more insights- please link to your discussions here for #trainees:
1. A) #monarchE: use of #abemiciclib in HR+, HER2-,high risk #EBC in addition to endocrine therapy.
Current #SOC: adjuvant ET (5-10 years)
#monarchE: #Abemaciclib + ET iDFS HR 0.747, here's a great summary by @ErikaHamilton9 for @OncoAlert :
Read 11 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!