Discover and read the best of Twitter Threads about #PathBoards
Most recents (9)
A 65 year old male presented with low urine output and bone pain. On further investigation serum creatinine was high and the patient had low hemoglobin. Bone marrow biopsy showed finding in the image. What is your diagnosis? #pathtwitter #pathtweetorial #pathresidents #pathboards 
Options
Answer is multiple myeloma.
The image shows "INTRA-NUCLEAR INCLUSIONS" called "DUTCHER BODIES".
They are deposits of immunoglobulins. Intracytoplasmic immunoglobulin inclusions are called RUSSEL BODIES.
Seen in multiple myeloma, plasmacytoma, lymphoplasmacytic lymphoma (LPL).
The image shows "INTRA-NUCLEAR INCLUSIONS" called "DUTCHER BODIES".
They are deposits of immunoglobulins. Intracytoplasmic immunoglobulin inclusions are called RUSSEL BODIES.
Seen in multiple myeloma, plasmacytoma, lymphoplasmacytic lymphoma (LPL).
A 48 year old male presented with submandibular swelling for 3 weeks.On examination the swelling was painless, solid, firm and immobile. Excision was performed. Hand E stained section of the tumour is shown below. What is your diagnosis? #pathtweetorial #pathboards #pathresidents
Options:
Answer is Acinic cell carcinoma -"acinic cells" (abundant finely vacuolated cytoplasm with basophilic granules, small nuclei with stippled chromatin), scattered "intercalcated duct type cells" (eosinophilic cytoplasm with moderate amount of cytoplasm and bland nuclei).
A 17-year old male presented with a breast lump . Gross and Microscopic images from the excised lump ( shown in the images). Identify the true statement? (Options in the comments) #pathology #PathTwitter #PathTwitterFamily #pathtweetorial #tweetorial #MedTwitter #pathboards
Options:
Diagnosis is juvenile papilomatosis.
Observe "swiss-cheese appearance" in gross and microscopy.
Other conditions with Swiss cheese appearance
Observe "swiss-cheese appearance" in gross and microscopy.
Other conditions with Swiss cheese appearance
Membranous type Basal Cell Adenoma (BCA).
🧨 Morphologically identical to cutaneous cylindroma, hence aka dermal analogue tumor.
🧨 This is a unique morphologic subtype that one should be aware of.
Why? Read below. #ENTpath
#pathology #pathboards #S&L 1/3
🧨 Morphologically identical to cutaneous cylindroma, hence aka dermal analogue tumor.
🧨 This is a unique morphologic subtype that one should be aware of.
Why? Read below. #ENTpath
#pathology #pathboards #S&L 1/3
🧨 Because this particular subtype can be multifocal.
🧨 This can be associated with Brooke Spiegler syndrome, a rare AD disease caused by mutation of CYLD gene on chr 16.
🧨 This has a higher rate of local recurrence (25%) than other subtypes. 2/3
🧨 This can be associated with Brooke Spiegler syndrome, a rare AD disease caused by mutation of CYLD gene on chr 16.
🧨 This has a higher rate of local recurrence (25%) than other subtypes. 2/3
🧨 And this has high propensity for transformation into a basal cell adenocarcinoma.
🔬 Islands of basaloid cells surrounded by eosinophilic hyaline material, jigsaw puzzle like pattern & peripheral palisading.
3/3 #S&L
🔬 Islands of basaloid cells surrounded by eosinophilic hyaline material, jigsaw puzzle like pattern & peripheral palisading.
3/3 #S&L
Young lady with weakness and anemia.
Endoscopy – diffuse scalloping of the duodenal mucosa
Biopsy – Mucosal flattening
Crypt hyperplasia
Intraepithelial lymphocytosis.
IgA anti-tissue transglutaminase (anti-TTG) NEGATIVE.
So, is this not celiac disease (CD)?
#GIpath #pathboards
Endoscopy – diffuse scalloping of the duodenal mucosa
Biopsy – Mucosal flattening
Crypt hyperplasia
Intraepithelial lymphocytosis.
IgA anti-tissue transglutaminase (anti-TTG) NEGATIVE.
So, is this not celiac disease (CD)?
#GIpath #pathboards
High clinical suspicion for CD -check IgA levels
In IgA deficiency, IgA-TTG and IgA-EMA (anti-endomysial Ab) will be negative
Alternative tests - IgG-DGP (deaminated gliadin peptide)/ IgG TTG
HLA-DQ typing - HLA-DQ2 (~95% pts) and HLA-DQ8
#GIpath #pathboards
In IgA deficiency, IgA-TTG and IgA-EMA (anti-endomysial Ab) will be negative
Alternative tests - IgG-DGP (deaminated gliadin peptide)/ IgG TTG
HLA-DQ typing - HLA-DQ2 (~95% pts) and HLA-DQ8
#GIpath #pathboards
Lastly, here's the colon bx of this pt showing lymphocytic colitis pattern
Microscopic colitis is more prevalent in pts w/ CD
Pts w/ MC and CD often have more severe histologic features, may require steroid rx
Response of MC to gluten free diet is not known.
#GIpath #pathboards
Microscopic colitis is more prevalent in pts w/ CD
Pts w/ MC and CD often have more severe histologic features, may require steroid rx
Response of MC to gluten free diet is not known.
#GIpath #pathboards
🤩I am constantly marveled by the endless ways in which we #Pathology and #LabMedicine, can use Twitter to engage, share, support & learn from each other. Here is the link to my presentation that celebrates the unlimited opportunities to harness Twitter👉🏽
bit.ly/39kA627
bit.ly/39kA627
Like the #SolarEclipse that occurred in August 2017, to me, Twitter has been a community wide experience of marveling a visual process that can create a burst of awe at an organic velocity. It's really exciting to be engaged in this global experience.
#AcademicTwitter is using Twitter at the University and Research setting to teach. It has wide range benefits and I recommend reading the following article written by @soragnilab and @Aiims1742 published in @nature that describes this phenomenon. doi.org/10.1038/s41568…
1/10
These are the lungs of a patient who died while receiving a PLT transfusion. He developed sudden respiratory distress and did not respond to O2 support. Lungs compressed by 3000 mL of transudative pleural fluid. Notice the increased neutrophils #PathTweetorial
These are the lungs of a patient who died while receiving a PLT transfusion. He developed sudden respiratory distress and did not respond to O2 support. Lungs compressed by 3000 mL of transudative pleural fluid. Notice the increased neutrophils #PathTweetorial
2/10
The above clinical scenario along with the histologic findings is consistent with which type of transfusion reaction?
#Blooducation #TransfusionReaction
The above clinical scenario along with the histologic findings is consistent with which type of transfusion reaction?
#Blooducation #TransfusionReaction
3/10
Yes, the histologic findings and clinical history is consistent with Transfusion-Related Acute Lung Injury (TRALI). Second to TACO, it is the most common cause of transfusion-related morbidities and fatalities. What causes it?
#Blooducation
Yes, the histologic findings and clinical history is consistent with Transfusion-Related Acute Lung Injury (TRALI). Second to TACO, it is the most common cause of transfusion-related morbidities and fatalities. What causes it?
#Blooducation
1/
Are you new to Twitter? Are you a pathology resident or a pathologist? Are you wondering what to tweet about or where to start? This brief tutorial is for you. Pathology on Twitter is awesome 👍🏾❤️✅
#Tweetorial = Tutorial of tweets
#pathtweetorial = Pathology version
Are you new to Twitter? Are you a pathology resident or a pathologist? Are you wondering what to tweet about or where to start? This brief tutorial is for you. Pathology on Twitter is awesome 👍🏾❤️✅
#Tweetorial = Tutorial of tweets
#pathtweetorial = Pathology version
2/
First step, check out this awesome guide to social media for newcomers. SUPER useful.
pathinfo.wikia.com/wiki/Social_Me…
It had great tips, like this one: ALWAYS include a picture of yourself on your profile. He’s right: please do it NOW! It’s essential. Just use a selfie 😊
First step, check out this awesome guide to social media for newcomers. SUPER useful.
pathinfo.wikia.com/wiki/Social_Me…
It had great tips, like this one: ALWAYS include a picture of yourself on your profile. He’s right: please do it NOW! It’s essential. Just use a selfie 😊
3/
Follow a few pathologists. Use this handy guide created by @RoseannIWu to begin with, and then just follow people whose tweets you like. Following is a friendly gesture on Twitter, and conveys that you are interested that person’s tweets.
Follow a few pathologists. Use this handy guide created by @RoseannIWu to begin with, and then just follow people whose tweets you like. Following is a friendly gesture on Twitter, and conveys that you are interested that person’s tweets.
1/2). 70yoM with 1 year hx of thrombocytosis and anemia, no splenomegaly, BCR/ABL(-),MPL(+). What is your dx? (Answer poll)
(2/2).What is the most likely diagnosis? (See case description)
1/4) This is a case of early PMF. The picture shows a hypercellular marrow with atypical megakaryocytes in dense clusters, and left-shifted granulocytic hyperplasia.
