Discover and read the best of Twitter Threads about #PediPath

Most recents (5)

227g placenta (>90% for gestational age)
#placentapath #pedipath

What are the green arrows pointing to?
Cysts! Let's go to the micro.

Here we see enlarged villi with myxoid stroma. The cystic structures on the gross correspond to this massive, cavernous cystic structure on the left

Hint: some might even call this a cistern.
The stem villus vessel shows luminal obliteration and associated fibrointimal proliferation, consistent with late stages of thrombosis.
Read 14 tweets
Age: 14-year old female
History: Proptosis & pain
Specimen: Exenteration
#pathology #PediPath #BSTPath #orbit

(*Image courtesy: Dr. Sayed Hashim)
3 main questions:
Q1. Is it benign or malignant?
Q2. If malignant - differentials?

DDx of orbital tumors in children:
1. Rhabdomyosarcoma (RMS)
2. Neuroblastoma
3. Synovial sarcoma
4. Chloroma
& so on
Read 28 tweets
H&E: Sorry @DrAhmedKalebi No pseudoepitheliomatous hyperplasia. @OkelloAliker

Any differential? Any IHC/molecular you would like to have?

I should also mention that the patient is immune compromised.
This turns out to be EBV-associated smooth muscle tumor (HE/SMA/EBER). Kudo to @lizawati38

3 spindle cell tumors in immune compromised:
- KS
- EBV-SMT
- microbacterial spindle cell pseudotumor

Without clinical history: ddx broader including all cellular spindle cell lesions.
Read 3 tweets
1/10 Ganglioglioma (GG)
Mixed neuronal-glial tumor
🔵composed of dysplastic neurons and glial component
Others features are,
🔵Delicate vasculature
🔵lymphocyte cuffs around vessels
🔵Calcifications
#pathology #PediPath #neuropath #Tweetorial
@sza_jhcyto @miguelguzmanmd @HopkinsNeuropth @edusqo @DrGeeONE @ariella8 @vi_monappa @BrainIsThePath @Path_Matt @JMGardnerMD 2/10 Glial component can resemble pilocytic astrocytoma with,
🔵Rosenthal fibers
🔵Eosinophilic granular bodies,
🔵oligodendroglioma and other gliomas-like components
#pathology #PediPath #neuropath
@sza_jhcyto @miguelguzmanmd @HopkinsNeuropth @edusqo @DrGeeONE @ariella8 @vi_monappa @BrainIsThePath @Path_Matt @JMGardnerMD 3/10 Neuronal component shows neurons with dysplasia
(dysmorphic neurons) characterized by:
🔵Clustering
🔵cytomegaly
🔵perimembranous aggregation of Nissl substance
🔵Binucleation
#pathology #PediPath #neuropath
Read 11 tweets
Painless hemiscrotal mass in a child, complex hydrocele on ultrasound.

Testis mass + smear... Fight!

#pedipath #gupath #cytopath
Rhabdomyosarcoma is indeed the top-level diagnosis... but more importantly, what type??

Note: several H&E patterns here that correspond nicely to the patterns on cytology.

#pedipath #gupath #pathology
Note the multiple patterns here - and see how they relate to myogenin staining.
This is an uncommon example of mixed-histology rhabdomyosarcoma.

Classic Embryonal - variable myogenin
Dense Emb/Solid Alveolar - strong, diffuse myogenin
Sclerosing - Weak/absent myogenin

#pedipath
Read 5 tweets

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