Discover and read the best of Twitter Threads about #PediPath
Most recents (5)
227g placenta (>90% for gestational age)
#placentapath #pedipath
What are the green arrows pointing to?
#placentapath #pedipath
What are the green arrows pointing to?
Cysts! Let's go to the micro.
Here we see enlarged villi with myxoid stroma. The cystic structures on the gross correspond to this massive, cavernous cystic structure on the left
Hint: some might even call this a cistern.
Here we see enlarged villi with myxoid stroma. The cystic structures on the gross correspond to this massive, cavernous cystic structure on the left
Hint: some might even call this a cistern.
The stem villus vessel shows luminal obliteration and associated fibrointimal proliferation, consistent with late stages of thrombosis.
Age: 14-year old female
History: Proptosis & pain
Specimen: Exenteration
#pathology #PediPath #BSTPath #orbit
(*Image courtesy: Dr. Sayed Hashim)
History: Proptosis & pain
Specimen: Exenteration
#pathology #PediPath #BSTPath #orbit
(*Image courtesy: Dr. Sayed Hashim)
3 main questions:
Q1. Is it benign or malignant?
Q1. Is it benign or malignant?
Q2. If malignant - differentials?
DDx of orbital tumors in children:
1. Rhabdomyosarcoma (RMS)
2. Neuroblastoma
3. Synovial sarcoma
4. Chloroma
& so on
DDx of orbital tumors in children:
1. Rhabdomyosarcoma (RMS)
2. Neuroblastoma
3. Synovial sarcoma
4. Chloroma
& so on
Time for another #grossognosis #ENTpath #Pedipath
Tongue lesion in a young kid.
@TheKarenPinto @renemaf @AnnieMcLeanDMD @DrAhmedKalebi @DrRolaAli @merva_st @TheKarenPinto @VijayPatho @doc_kartik @luishcruzc @kis_lorand
Tongue lesion in a young kid.
@TheKarenPinto @renemaf @AnnieMcLeanDMD @DrAhmedKalebi @DrRolaAli @merva_st @TheKarenPinto @VijayPatho @doc_kartik @luishcruzc @kis_lorand
H&E: Sorry @DrAhmedKalebi No pseudoepitheliomatous hyperplasia. @OkelloAliker
Any differential? Any IHC/molecular you would like to have?
I should also mention that the patient is immune compromised.
Any differential? Any IHC/molecular you would like to have?
I should also mention that the patient is immune compromised.
This turns out to be EBV-associated smooth muscle tumor (HE/SMA/EBER). Kudo to @lizawati38
3 spindle cell tumors in immune compromised:
- KS
- EBV-SMT
- microbacterial spindle cell pseudotumor
Without clinical history: ddx broader including all cellular spindle cell lesions.
3 spindle cell tumors in immune compromised:
- KS
- EBV-SMT
- microbacterial spindle cell pseudotumor
Without clinical history: ddx broader including all cellular spindle cell lesions.
1/10 Ganglioglioma (GG)
Mixed neuronal-glial tumor
🔵composed of dysplastic neurons and glial component
Others features are,
🔵Delicate vasculature
🔵lymphocyte cuffs around vessels
🔵Calcifications
#pathology #PediPath #neuropath #Tweetorial
Mixed neuronal-glial tumor
🔵composed of dysplastic neurons and glial component
Others features are,
🔵Delicate vasculature
🔵lymphocyte cuffs around vessels
🔵Calcifications
#pathology #PediPath #neuropath #Tweetorial
@sza_jhcyto @miguelguzmanmd @HopkinsNeuropth @edusqo @DrGeeONE @ariella8 @vi_monappa @BrainIsThePath @Path_Matt @JMGardnerMD 2/10 Glial component can resemble pilocytic astrocytoma with,
🔵Rosenthal fibers
🔵Eosinophilic granular bodies,
🔵oligodendroglioma and other gliomas-like components
#pathology #PediPath #neuropath
🔵Rosenthal fibers
🔵Eosinophilic granular bodies,
🔵oligodendroglioma and other gliomas-like components
#pathology #PediPath #neuropath
@sza_jhcyto @miguelguzmanmd @HopkinsNeuropth @edusqo @DrGeeONE @ariella8 @vi_monappa @BrainIsThePath @Path_Matt @JMGardnerMD 3/10 Neuronal component shows neurons with dysplasia
(dysmorphic neurons) characterized by:
🔵Clustering
🔵cytomegaly
🔵perimembranous aggregation of Nissl substance
🔵Binucleation
#pathology #PediPath #neuropath
(dysmorphic neurons) characterized by:
🔵Clustering
🔵cytomegaly
🔵perimembranous aggregation of Nissl substance
🔵Binucleation
#pathology #PediPath #neuropath
Painless hemiscrotal mass in a child, complex hydrocele on ultrasound.
Testis mass + smear... Fight!
#pedipath #gupath #cytopath
Testis mass + smear... Fight!
#pedipath #gupath #cytopath
Rhabdomyosarcoma is indeed the top-level diagnosis... but more importantly, what type??
Note: several H&E patterns here that correspond nicely to the patterns on cytology.
#pedipath #gupath #pathology
Note: several H&E patterns here that correspond nicely to the patterns on cytology.
#pedipath #gupath #pathology
Note the multiple patterns here - and see how they relate to myogenin staining.
This is an uncommon example of mixed-histology rhabdomyosarcoma.
Classic Embryonal - variable myogenin
Dense Emb/Solid Alveolar - strong, diffuse myogenin
Sclerosing - Weak/absent myogenin
#pedipath
This is an uncommon example of mixed-histology rhabdomyosarcoma.
Classic Embryonal - variable myogenin
Dense Emb/Solid Alveolar - strong, diffuse myogenin
Sclerosing - Weak/absent myogenin
#pedipath
