Discover and read the best of Twitter Threads about #Periodontal
Most recents (3)
#WeekendLecture
#ISC22
Highlights
300 invited talks
Nearly 200 oral abstracts
>1000 posters
Here we review some of trials and presentation from Main Events at #ISC22
#ISC22
Highlights
300 invited talks
Nearly 200 oral abstracts
>1000 posters
Here we review some of trials and presentation from Main Events at #ISC22
#ISC22 Highlights
#RESCUE_Japan LIMIT
EVT for acute LVO with #large ischemic #Core
NIHSS>6, #ASPECT 3-5 , CT or MRI (~85%)
<6hr, or DWI/FLAIR mismatch <24hr
🚶mRS 0-3 at 90d: 31 vs 12.8%, RR 2.43🩸sICH,<48hr: 9 vs 4.9% NS
⚫️Death: 18 vs 23.5%, NS
nejm.org/doi/full/10.10…
#RESCUE_Japan LIMIT
EVT for acute LVO with #large ischemic #Core
NIHSS>6, #ASPECT 3-5 , CT or MRI (~85%)
<6hr, or DWI/FLAIR mismatch <24hr
🚶mRS 0-3 at 90d: 31 vs 12.8%, RR 2.43🩸sICH,<48hr: 9 vs 4.9% NS
⚫️Death: 18 vs 23.5%, NS
nejm.org/doi/full/10.10…
#ISC22 Highlights
#Rescue-BT EVT with or w/o #tirofiban in LVO stroke
GPIIb/IIIa-R inhibitor could ⏬reocclusion after MT
55🏥in🇨🇳AIS<24hr, no IVT, ASPECT≥6
950pts
🚶mRS at 90d: 3 vs 3
🩸sICH: 9.7 vs 6.4%, NS
⚫️Death: 18.1 vs 16.9%
Treatment effect modification in LAA subgroup
#Rescue-BT EVT with or w/o #tirofiban in LVO stroke
GPIIb/IIIa-R inhibitor could ⏬reocclusion after MT
55🏥in🇨🇳AIS<24hr, no IVT, ASPECT≥6
950pts
🚶mRS at 90d: 3 vs 3
🩸sICH: 9.7 vs 6.4%, NS
⚫️Death: 18.1 vs 16.9%
Treatment effect modification in LAA subgroup
Nice work @drmfreire + team at @JCVenterInst! 👉 They found that local #periodontal pathogen enrichment was positively associated with high systemic inflammatory profiles in patients with Systemic #Lupus Erythematosus: biorxiv.org/content/10.110…
Quote from paper 👉 “...the gut #microbiome, and recently the #oral microbiome, showed direct impact on SLE subjects, the complexity of chronic diseases such as #SLE is beyond isolated body compartments, and it requires the integration of host-microbial interactions.”
Also 👉 “At the center of #autoimmune pathogenesis, this study provides evidence that #inflammatory response to #microbiome controls the severity, and magnitude of the #SLE disease”
This paper summarizes a wealth of studies which show a growing link b/t #periodontal (oral) pathogens and systemic diseases 👉 ...including cardiovascular disease, GI #cancers, diabetes, Alzheimer’s and (very importantly!) adverse pregnancy outcomes: sciencedirect.com/science/articl…
For example 👉 “Respiratory #pathogens isolated from dental plaque and bronchoalveolar lavage fluid from the same patients...were shown to be genetically the same, which reinforces the view that #dental plaque could serve as a significant reservoir for #respiratory pathogens”
Or this study 👉 in which oral pathogen F. nucleatum was found in higher numbers in human #colonic adenomas relative to surrounding tissues and in #stool samples from patients with colorectal carcinoma: sciencedirect.com/science/articl…
