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A TWEETORIAL on our new CRISPR-sciATAC preprint. Our lab has been working on combining pooled CRISPR screens with single-cell chromatin accessibility for nearly 4 years so very happy to see this work finally out there in the world.
biorxiv.org/content/10.110…
The work was led by 2 talented postdocs in our lab (@noaliscovitch and @antonino_nyc) with support from many other folks in our lab and in @NYGCTech lab. Extra shout-out to @noaliscovitch for getting the manuscript over the final hump in what has been a challenging year.
When we started, we were impressed by the diverse methods (e.g. ECCITE-seq, Perturb-seq, CROP-seq) for combining pooled CRISPR screens with single-cell RNA-seq and wondered if we could do something similar with chromatin accessibility (ATAC-seq).
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