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1/ When the world is chaos I find myself turning to nature, reflecting & often thinking too much...

#ASCO21 reminded me how a lot people know that Paclitaxel/Taxol, a gold standard chemotherapy agent for various cancers, was derived from the bark of the Pacific Yew Tree...🧵
2/ Taxus brevifolia, BUT people might not know that the part of the tree with the highest concentration of this molecule is the inner bark called the vascular cambial region & phloem.

This serves as a living tissue transporting minerals from the earth and sugar from its leaves
3/ As well as other nutrients & hormones throughout the tree.

What is really interesting is that this structure only lives for a short time, then dies and becomes part of the protective outer bark layer.

The antineoplastic molecule they found is in this tube of tissue.
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