Discover and read the best of Twitter Threads about #PlasmaTherapy
Most recents (17)
Early use of high titer neutralisatiing Convalescent Plasma in outpatients reduce hospitalisation. 1/n
#COVID19 #PlasmaTherapy
medrxiv.org/content/10.110…
#COVID19 #PlasmaTherapy
medrxiv.org/content/10.110…
So what was wrong with previous attempts at Plasma therapy?
1) Reliable assays for Neutralising Antibodies werent widely available earlier
2) We did not know what titer was high enough
3) Most studies were done in serious ill hospitalised patients 2/n
1) Reliable assays for Neutralising Antibodies werent widely available earlier
2) We did not know what titer was high enough
3) Most studies were done in serious ill hospitalised patients 2/n
Why do we need convalescent Plasma in the age of Monoclonal antibodies?
Most monoclonal antibodies are ineffective against Omicron and the ones that retain activity are limited in supply and hoarded by @JoeBiden
Other folks at high risk may need an alternative 3/n
Most monoclonal antibodies are ineffective against Omicron and the ones that retain activity are limited in supply and hoarded by @JoeBiden
Other folks at high risk may need an alternative 3/n
What saved my brother when all hope was God was #plasma. He responded to the 1st unit given to him & the 2nd one got him off oxygen support. Many suffering under this strain have recovered with/after #PlasmaTherapy. Is this coz there's a shortage? #COVID19 #CovidIndia @PMOIndia
Making #PlasmaTherapy illegal is liking tying the hands of our docs & telling them to save lives. Are you trying to kill people? First no oxygen supply & now this!
I ask you, is it harming anyone? Are there any sideeffects? The ministry talks like they have it all figured out.
I ask you, is it harming anyone? Are there any sideeffects? The ministry talks like they have it all figured out.
Shortage of a medicine in the market doesn't render it unnecessary as the govt would have us believe. It doesn't have to be a miracle cure. First, rem's not needed (now DRDO will save us all). Then, why Delhi needs more 02 than Mumbai (asked in SC. new, more virulent strain?!)
I'm collating a thread of resources showing that #PlasmaTherapy doesn't really work & can in fact, lead to the emergence of more virulent strains of #COVID19!
These resources are at varying levels of reading difficulty + reading times needed.
Pls RT and/or add more resources👇🏼
These resources are at varying levels of reading difficulty + reading times needed.
Pls RT and/or add more resources👇🏼
First, here's a short and accessible mega-thread by @netshrink that quotes several other scientists who have also publicly spoken about plasma therapy not working!
@GKangInd @MenonBioPhysics @AnantBhan @vishuguttal
@GKangInd @MenonBioPhysics @AnantBhan @vishuguttal
Second, here's a comprehensive article by @sandygrains for @ThePrintIndia clarifying the effectiveness of several potential treatments for Covid, including remdesivir, plasma therapy & more!
@IndiaBioscience @IndSciComm @IndiaCOVIDSOS @IndSciCOVID
theprint.in/health/dexamet…
@IndiaBioscience @IndSciComm @IndiaCOVIDSOS @IndSciCOVID
theprint.in/health/dexamet…
#Plasmadonation..one of the most used term nowadays, ofcorse this arouses lots of queries in a donor's mind..
Let's see if this helps to clear the air to some extent 👍summerized in 10 points.
#covidcapsules #plasmatherapy
#covidupdates
Let's see if this helps to clear the air to some extent 👍summerized in 10 points.
#covidcapsules #plasmatherapy
#covidupdates
Among the 3 categories of COVID patients (severe, moderate ,mild), plasma therapy is suggested for patients who have been moderately infected.Patients with mild condition often recover easily themselves, whereas the chances of recovery in a severely-infected patient are slim.
When one contracts an infection, especially a viral infection, their recovery depends on the production of antibodies to fight the antigen ( which in the current case, is COVID-19). These antibodies are present in the recovered person’s blood for a few weeks aftr recovery.
.@ICMRDELHI study on #plasmatherapy in #COVID19 pts initiated a debate. This thread collates experiences across India on the therapy starting with #Delhi Health Minister,@SatyendarJain. CM @ArvindKejriwal mentioned 1965 patients got befitted already. (1/n)
google.com/amp/s/www.ndtv…
google.com/amp/s/www.ndtv…
Mr. Jain clarified that the @ICMRDELHI study doesn't say there are no benefits of plasma therapy, it says CPT may not be effective for a patient on ventilation. He said plasma therapy does not benefit those at stage 3 of the disease. But it helps those in stages 1 and 2. (2/n)
Doctors across Delhi shared their experiences in treating patients with plasma and commented that the therapy is bringing promising results in absence of a vaccine or other mode of treatment. (3/n)
timesofindia.indiatimes.com/india/despite-…
timesofindia.indiatimes.com/india/despite-…
As several case studies from India produced good results in convalescent plasma therapy, we need more evidence to get to the bottom of this therapeutic aspect.
I have nothing against #PlasmaTherapy for Covid. I've looked at the data. It might be helpful. We need a trial.
Now, imagine if the attention paid to this *one potentially marginally helpful therapy*....
...was devoted, as well (not even "instead") to those sick with Covid. /1
Now, imagine if the attention paid to this *one potentially marginally helpful therapy*....
...was devoted, as well (not even "instead") to those sick with Covid. /1
What I mean is this. I'm a believer in biomedical interventions. Heck, I'm a board certified internist. Biomedicine is part of what I do.
But only a part.
So much of the help I try to give patients is not available./2
But only a part.
So much of the help I try to give patients is not available./2
Not because "it's not my expertise" or any such Pinkerian BS. It's because our priorities are off.
Can we pay workers to stay home?
Can we cancel rent?
Can we give food to the hungry?
Can we make Covid care free?
Darn right we can. /3
Can we pay workers to stay home?
Can we cancel rent?
Can we give food to the hungry?
Can we make Covid care free?
Darn right we can. /3
Few IMPORTANT updates on #COVID19 across globe and India: Stay up to date.
1. #UnitedKingdom govt. imposed tougher fines of up to 10k pounds on illegal gatherings, parties & raves of >30 people as part of stricter measures to combat the spread of pandemic.
1. #UnitedKingdom govt. imposed tougher fines of up to 10k pounds on illegal gatherings, parties & raves of >30 people as part of stricter measures to combat the spread of pandemic.
2. A new COVID-19 cluster has been reported in #Singapore's biggest dormitory housing foreign workers, about a month after it was declared to be fully cleared of COVID 19.
3. The coronavirus is circulating 4 times more among people under 40 in #France than among those over 65.
3. The coronavirus is circulating 4 times more among people under 40 in #France than among those over 65.
4. A team of researchers in #Germany staged an elaborate experimental indoor concert, complete with 1,500 attendees & a musical act to study how to limit the spread of the deadly COVID-19 virus at big events.
5. India's recovery rate to nearly 75%, while the CFR reaches 1.86%.
5. India's recovery rate to nearly 75%, while the CFR reaches 1.86%.
NEWS: @realDonaldTrump announces @US_FDA has issued an emergency use authorization (EUA) for convalescent plasma for the treatment of #COVID19 in hospitalized patients
Earlier on @FaceTheNation Sunday, @ScottGottliebMD explained how the "breakthrough" works and what it means
Earlier on @FaceTheNation Sunday, @ScottGottliebMD explained how the "breakthrough" works and what it means
.@HHSGov's @SecAzar on #PlasmaDonation:
"This is a major advance in the treatment of patients...Americans who tested positive for and recovered from #COVID19 can go to coronavirus.gov to find a way to play a life saving role in the fight"
"This is a major advance in the treatment of patients...Americans who tested positive for and recovered from #COVID19 can go to coronavirus.gov to find a way to play a life saving role in the fight"
.@US_FDA's @SteveFDA explains how #PlasmaTherapy works to treat #COVID19 patients:
"Close to 100,000 Americans have enrolled in this program, and over 70,000 have received treatment. This is one of the largest expanded access programs in the history of FDA"
"Close to 100,000 Americans have enrolled in this program, and over 70,000 have received treatment. This is one of the largest expanded access programs in the history of FDA"
#Thread #PlasmaTherapy #ପ୍ରଶ୍ନୋତ୍ତର
୧
ପ୍ର:- କିଏ ଦେବ ପ୍ଲାଜମା ?
ଉ:-
-ଯାହାକୁ ଆଗରୁ କୋଭିଡ ଭଲ ହେଇଥିବ ୨୮ ଦିନ ତଳେ,
-କିମ୍ବା ୧୪ ଦିନ ତଳେ ଲକ୍ଷଣ ଛାଡିଥିବ ଓ ଟେଷ୍ଟ ଏବେ ନେଗେଟିଭ୍ ଥିବ। ୧୪ ଦିନପରେ ଟେଷ୍ଟ ପଜିଟିଭ ରହିଲେବି ଦେଇହେବ, କାରଣ ସଂକ୍ରମଣ ଶକ୍ତି ନଥାଏ। ୧୪ ଦିନପରେ ଟେଷ୍ଟ କରିବାବି ନିହାତି ଆବଶ୍ୟକ ନୁହେଁ।
cntd
୧
ପ୍ର:- କିଏ ଦେବ ପ୍ଲାଜମା ?
ଉ:-
-ଯାହାକୁ ଆଗରୁ କୋଭିଡ ଭଲ ହେଇଥିବ ୨୮ ଦିନ ତଳେ,
-କିମ୍ବା ୧୪ ଦିନ ତଳେ ଲକ୍ଷଣ ଛାଡିଥିବ ଓ ଟେଷ୍ଟ ଏବେ ନେଗେଟିଭ୍ ଥିବ। ୧୪ ଦିନପରେ ଟେଷ୍ଟ ପଜିଟିଭ ରହିଲେବି ଦେଇହେବ, କାରଣ ସଂକ୍ରମଣ ଶକ୍ତି ନଥାଏ। ୧୪ ଦିନପରେ ଟେଷ୍ଟ କରିବାବି ନିହାତି ଆବଶ୍ୟକ ନୁହେଁ।
cntd
୨
- ରୋଗ ଅଛିକି ନାହିଁ rtPCR ପରୀକ୍ଷା(ନାଜାଲ ସ୍ବାବ) ହେଇଥିଲେ ଭଲ
-ମୂଳରୁ ଲକ୍ଷଣବିହୀନ ଥିବା ରୋଗୀବି ଦେଇପାରିବେ
-ସେରୋଲୋଜି ସର୍ଭେରେ ଆଇଜି ଆଣ୍ଟିବଡି ପଜିଟିଭ ଥିବା ଅଜଣା-ରୋଗୀବି ଦେଇପାରିବେ
-ଆଣ୍ଟିବଡି ଟାଇଟର(ଲେବଲ) ମାପିବା ଦରକାର ନାହିଁ, ଯଦି ମାପିହେବ, 1:160ରୁ ଅଧିକ ଥିଲେ ଭଲ
- ରୋଗ ଅଛିକି ନାହିଁ rtPCR ପରୀକ୍ଷା(ନାଜାଲ ସ୍ବାବ) ହେଇଥିଲେ ଭଲ
-ମୂଳରୁ ଲକ୍ଷଣବିହୀନ ଥିବା ରୋଗୀବି ଦେଇପାରିବେ
-ସେରୋଲୋଜି ସର୍ଭେରେ ଆଇଜି ଆଣ୍ଟିବଡି ପଜିଟିଭ ଥିବା ଅଜଣା-ରୋଗୀବି ଦେଇପାରିବେ
-ଆଣ୍ଟିବଡି ଟାଇଟର(ଲେବଲ) ମାପିବା ଦରକାର ନାହିଁ, ଯଦି ମାପିହେବ, 1:160ରୁ ଅଧିକ ଥିଲେ ଭଲ
୩
ପ୍ର:- ପ୍ଲାଜମା ଦେବାର ଅନ୍ୟ କ୍ରାଇଟେରିଆ କଣ?
ଉ:-
- 18-60 ବୟସ
- 50 କେଜି ଓଜନ
- ହେମୋଗ୍ଲୋବିନ 8-10 ରୁ ଅଧିକ
- ୧୪-୨୮ ଦିନ ପୂର୍ବରୁ ଲକ୍ଷଣ ଭଲହେଇଯାଇଥିବ
ପ୍ର:- ପ୍ଲାଜମା ଦେବାର ଅନ୍ୟ କ୍ରାଇଟେରିଆ କଣ?
ଉ:-
- 18-60 ବୟସ
- 50 କେଜି ଓଜନ
- ହେମୋଗ୍ଲୋବିନ 8-10 ରୁ ଅଧିକ
- ୧୪-୨୮ ଦିନ ପୂର୍ବରୁ ଲକ୍ଷଣ ଭଲହେଇଯାଇଥିବ
#Ayurveda #Herbal #real #Tales
1
Saw 64y old #patient with #jaundice and severe #itching all over #body (called #cholestatic #hepatitis) in OPD. Went to 3 other #hospitals prior, always evaluated for #liver and #bileduct #Cancer. Always cancer tests #Negative. Liverbiopsy👇
1
Saw 64y old #patient with #jaundice and severe #itching all over #body (called #cholestatic #hepatitis) in OPD. Went to 3 other #hospitals prior, always evaluated for #liver and #bileduct #Cancer. Always cancer tests #Negative. Liverbiopsy👇
2
Biopsy shows severe #bile stagnation (#cholestasis) in liver #cells and bile-ducts with #inflammation and #swelling of livercells (#hepatocyte) - classical picture of cholestatichepatitis. CT of liver normal, #MRCP (to see bile ducts) - normal #livertwitter #pathology
CAUSE👇
Biopsy shows severe #bile stagnation (#cholestasis) in liver #cells and bile-ducts with #inflammation and #swelling of livercells (#hepatocyte) - classical picture of cholestatichepatitis. CT of liver normal, #MRCP (to see bile ducts) - normal #livertwitter #pathology
CAUSE👇
3
Patient has #diabetes. Tired of #insulin #diet control. #Ayurvedic #physician advises - stop insulin, start #natural side effect free #treatment. Gives these #CAPSULE . After 6 months on #tablet - liver injury and symptoms start. #nutrition deprived, sugar controlled. #MedEd
Patient has #diabetes. Tired of #insulin #diet control. #Ayurvedic #physician advises - stop insulin, start #natural side effect free #treatment. Gives these #CAPSULE . After 6 months on #tablet - liver injury and symptoms start. #nutrition deprived, sugar controlled. #MedEd
#WorldBloodDonorDay2020: Century-old Convalescent Plasma Therapy Ignites New Hopes for #COVID19 Treatment
weather.com/en-IN/india/ne…
#WorldBloodDonorDay #coronavirus
(📸: Mahesh G/BCCL Vijayawada)
weather.com/en-IN/india/ne…
#WorldBloodDonorDay #coronavirus
(📸: Mahesh G/BCCL Vijayawada)
Experts continue to stress that the therapy holds promise, and there is a growing need for plasma donors across the country to give a fighting chance for #COVID19 patients with severe symptoms.
➡️What is convalescent plasma therapy?⬅️
It is a passive antibody therapy where the immunity of a recovered patient is transferred to a sick person using blood plasma. When attacked by a pathogen, our immune system produces proteins called antibodies to fight the infection.
It is a passive antibody therapy where the immunity of a recovered patient is transferred to a sick person using blood plasma. When attacked by a pathogen, our immune system produces proteins called antibodies to fight the infection.
20 March: Dr Tahir Shamsi @62Shamsi Dean & Professor of Medicine, National Institute of Blood Diseases (#NIBD) suggests convalescent #plasma (CP) #treatment for patients with serious #Covid_19 infection
7 April: Drug Regulatory Authority of Pakistan (DRAP) approved CP treatment
7 April: Drug Regulatory Authority of Pakistan (DRAP) approved CP treatment
30 April: Trials begin at 3 hospitals in Sindh ~ NIBD, Dr Ruth Pfau Civil Hospital Karachi & Liaquat University Hospital in Hyderabad
10 May: Five more hospitals across Pakistan sought DRAP nod to conduct clinical trials for passive immunisation
10 May: Five more hospitals across Pakistan sought DRAP nod to conduct clinical trials for passive immunisation
Dr Zafar Mirza, Special Assistant to PM on Health unsupportive of suggestion, until “fairy” said it’s going to happen & he subsequently announced DRAP approval
9 June: Dr Zafar Mirza tweets list of approved hospitals, without naming NIBD, the pilot institute or Dr. Tahir Shamsi
9 June: Dr Zafar Mirza tweets list of approved hospitals, without naming NIBD, the pilot institute or Dr. Tahir Shamsi
Terapi plasma convalescent / #PlasmaTherapy mulai bisa d bkin ni di Indonesia. Mungkin bs jd terapi unggulan negri kita yang byk penduduknya buat yang udah sembuh dari #COVID19 jd donatur antibodi d kala obt n vaksin blon d temukan dan klo d temukan pasti impor @blogdokter
Oyah bagi yang minat boleh langsung menghubungi or melipir di sini ya... Thank u for sharing. Karena plasma anda berguna untuk orang lain... @blogdokter
Bisa juga hubungi rekan sejawat kami di sini @noichil
Dopo la seconda sacca di PLASMA IPERIMMUNE, tempo un’ora, sparisce la febbre. In una settimana dall’infusione c’è la guarigione completa da una grave infezione di #Covid19, con tamponi negativi al virus.
#coronavirus
#PlasmaTherapy
#covid19
#coronavirus
#PlasmaTherapy
#covid19
“Il plasma, in questo momento, è l’unico farmaco specifico contro #Covid19. Inoculando gli anticorpi dei guariti nelle persone malate è come se somministrassimo l'analogo di un vaccino”.
Giuseppe De Donno, primario del reparto di pneumologia dell'ospedale Carlo Poma di Mantova
Giuseppe De Donno, primario del reparto di pneumologia dell'ospedale Carlo Poma di Mantova
La terapia con PLASMA IPERIMMUNE si basa sul fatto che il plasma di donatore contiene gli anticorpi contro il #coronavirus.
#covid19
#covid19
The first patient who was administered "Plasma Therapy" on compassionate grounds at Max Hospital, has shown positive results & was recently weaned off ventilator support. The patient is a 49-year-old, male from Delhi.
#DelhiFightsCorona
#IndiaFightsCorona
#PlasmaTherapy
#DelhiFightsCorona
#IndiaFightsCorona
#PlasmaTherapy
47 Y old #COVIDー19 Pt w/ comorbid conditions like diabetes & hypertension IMPROVED on Plasma therapy at #Pune state hospital. #plasmatheraphy #IndiaFightsCorona
tinyurl.com/ya2ewv43
@BollyNumbers @vinayverma99 @Sudhani @SanjayJog7 @CMOMaharashtra. @Abhinav75203891 👍
tinyurl.com/ya2ewv43
@BollyNumbers @vinayverma99 @Sudhani @SanjayJog7 @CMOMaharashtra. @Abhinav75203891 👍
As the world is debating over medicines for #COVIDー19, monoclonal human neutralising antibodies are showing promising result in both prevention & treatment. Crisp report by @EricTopol. #plasmatheraphy #COVID #COVID19India
#Plasmatherapy has been tried in SARS, H1N1 and EBOLA outbreaks in past as well. The plasma of patients that have recovered is called convalescent ( kan- val-ascent) plasma and is rich in antibodies (proteins that are produced by human body against infectious or foreign agent)
These antibodies neutralise the virus and help in recovery of critically ill by reducing the viral load. Convalescent plasma ( CP) has mainly been used as a last resort in critical cases. In current epidemic also was used in China for a small no of cases and been found helpful.
Issues with this treatment are:
1. It has not yet been tried on a large scale in COVID19.
2. Patients who recover from coronavirus infection must volunteer to donate blood.
3. Transfusions carry risk of reaction called transfusion reactions, some of which can be life threatening.
1. It has not yet been tried on a large scale in COVID19.
2. Patients who recover from coronavirus infection must volunteer to donate blood.
3. Transfusions carry risk of reaction called transfusion reactions, some of which can be life threatening.
