Discover and read the best of Twitter Threads about #Platelets
Most recents (10)
Even #mild #COVID #infection increases risk of #blood #clots and #death
A study in the UK found that mild (non-hospitalized) infections led to a 2.7x higher risk of blood clots and 10.2x higher risk of death compared to controls ( heart.bmj.com/node/174901.fu… ). H/T: @LauraMiers 🧵1/
A study in the UK found that mild (non-hospitalized) infections led to a 2.7x higher risk of blood clots and 10.2x higher risk of death compared to controls ( heart.bmj.com/node/174901.fu… ). H/T: @LauraMiers 🧵1/
The study looked at 17,871 COVID-19 cases in the UK between March 2020 and March 2021. People hospitalized *for* COVID-19 were at even higher risk:
118.0x = All-cause Death
27.6 = Venous Thromboembolism (blood clots)
21.6x = Heart Failure
17.5x = Stroke
2/
118.0x = All-cause Death
27.6 = Venous Thromboembolism (blood clots)
21.6x = Heart Failure
17.5x = Stroke
2/
14.9x = Atrial Fibrillation (AF)
13.6x = Pericarditis
9.9x = Myocardial Infarction (heart attack)
3/
13.6x = Pericarditis
9.9x = Myocardial Infarction (heart attack)
3/
#Prayagraj व देश में #dengue के बढ़ते केस व #platelets के लिए मचे हाहाकार के कारण मैं ये पोस्ट पुनः लिख रहा हूँ!
घर पर बन सकने वाला ये #Ayurveda #काढ़ा #प्लेट्लेट्स संख्या कम होने से सफलतापूर्वक रोकता है, ऐसा मेरा 12 वर्षों का अनुभव है!
कृपया शेयर कर लोगों की सहायता करें!
1/n
घर पर बन सकने वाला ये #Ayurveda #काढ़ा #प्लेट्लेट्स संख्या कम होने से सफलतापूर्वक रोकता है, ऐसा मेरा 12 वर्षों का अनुभव है!
कृपया शेयर कर लोगों की सहायता करें!
1/n
2/n
हर साल ये काढ़ा मैं हज़ारों मरीज़ों को देता रहा हूँ, लेकिन फिर भी असंख्य मरीज़ों को ये काढ़ा मैं नहीं दे पाता हूँ,
इसलिए इस काढ़े को #घर_पर_बनाने_का_तरीक़ा मैं फिर से शेयर कर रहा हूँ, ताकि आप इसे घर पर भी भविष्य की ज़रूरत के लिए बना कर रख सकें!
हर साल ये काढ़ा मैं हज़ारों मरीज़ों को देता रहा हूँ, लेकिन फिर भी असंख्य मरीज़ों को ये काढ़ा मैं नहीं दे पाता हूँ,
इसलिए इस काढ़े को #घर_पर_बनाने_का_तरीक़ा मैं फिर से शेयर कर रहा हूँ, ताकि आप इसे घर पर भी भविष्य की ज़रूरत के लिए बना कर रख सकें!
3/n
STEP_1
1 लीटर काढ़ा बनाने में मात्र लगभग ₹3000/ का खर्च आता है (अगर जड़ी बूटियाँ ठीक मिल जाएँ तो), और इतना काढ़ा #Dengue के 2 रोगियों के लिए पर्याप्त है!
निम्नलिखित सूखी हुयी जड़ी-बूटियों को बराबर मात्रा में लीजिएः
1. अतिविषा
2. द्रोणपुष्पी
3. वासा
4. हरीतकी..
STEP_1
1 लीटर काढ़ा बनाने में मात्र लगभग ₹3000/ का खर्च आता है (अगर जड़ी बूटियाँ ठीक मिल जाएँ तो), और इतना काढ़ा #Dengue के 2 रोगियों के लिए पर्याप्त है!
निम्नलिखित सूखी हुयी जड़ी-बूटियों को बराबर मात्रा में लीजिएः
1. अतिविषा
2. द्रोणपुष्पी
3. वासा
4. हरीतकी..
1) Welcome to an #accredited #tweetorial on a unique emerging (in Ph3 now) option for specifically reversing the #antiplatelet effects of #ticagrelor: it's #bentracimab. Expert faculty is antithrombotic agent reversal guru @md_pollack of @UMMCnews, working to create #AHealthierMS
2) This program is intended for #healthcare professionals and is supported by an educational grant from PhaseBio Pharmaceuticals. Faculty disclosures are listed at cardiometabolic-ce.com/disclosures/, and prior programs are available for 🆓CE/#CME credit at cardiometabolic-ce.com.
3) It is an unfortunate fact of life that one cannot prescribe #anticoagulant or #antiplatelet (together, #antithrombotic) therapy without increasing a patient's #bleedingrisk. That is why it should be an individualized risk:benefit decision, ideally . . .
Govt of Canada marketing delivered to my home.
"The #vaccinations are safe."
"Up to and including July 16, 2021, a total of 152 deaths were reported after the administration of a vaccine."
Adverse events of special interest as of July 16 2021: 1,675👇
health-infobase.canada.ca/covid-19/vacci…
"The #vaccinations are safe."
"Up to and including July 16, 2021, a total of 152 deaths were reported after the administration of a vaccine."
Adverse events of special interest as of July 16 2021: 1,675👇
health-infobase.canada.ca/covid-19/vacci…
#Autoimmune diseases:
Guillain-Barré Syndrome: 48
Thrombocytopenia (low blood platelets): 61
#Cardiovascular system:
Cardiac arrest:20
Cardiac failure: 13
Heart attack: 52
#Myocarditis / #Pericarditis: 211
health-infobase.canada.ca/covid-19/vacci…
Guillain-Barré Syndrome: 48
Thrombocytopenia (low blood platelets): 61
#Cardiovascular system:
Cardiac arrest:20
Cardiac failure: 13
Heart attack: 52
#Myocarditis / #Pericarditis: 211
health-infobase.canada.ca/covid-19/vacci…
Adverse reactions continued.
#Circulatory system:
Deep vein #thrombosis: 134
Pulmonary #embolism: 202
#Thrombosis (blood clot): 126
Thrombosis with thrombocytopenia syndrome (blood clot w/ low #platelets): 67
+++
Acute kidney injury: 19
Liver injury: 9
See all👇
#Circulatory system:
Deep vein #thrombosis: 134
Pulmonary #embolism: 202
#Thrombosis (blood clot): 126
Thrombosis with thrombocytopenia syndrome (blood clot w/ low #platelets): 67
+++
Acute kidney injury: 19
Liver injury: 9
See all👇
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
Platelets are sufficient to drive inflammasome up regulation and activation in myeloid cells, and are *necessary* for full IL-1 production biorxiv.org/content/10.110…. Another great platelet immunology preprint! @bernardo647 #Immunology #Platelets #Inflammasome
Looking at malaria patients with thrombocytopenia shows decreased circulating IL-1 inversely correlating with platelet, but not total leukocyte, numbers, and depletion during PBMC prep almost eliminated IL-1 (and TNF) production in response to LPS!
This preprint also has very thorough evidence that platelets *do not* express inflammasomes or meaningfully contribute IL-1/18, and an exhaustive list of all the ways that platelets *don’t* stimulate myeloid inflammasome activation. Super solid work!
This preprint has it all - explanation of human genetics, platelets as immunomodulators, a new protein-protein interaction involving a solute carrier, NETs biorxiv.org/content/10.110…. And amazing movies! #Immunology #Biochemistry #Platelets
Microfluidics and imaging show binding of neutrophils (and T cells) to activated aIIb-b3 integrin on platelets - independent of known receptors. SLC44A2 binds, and a human SNP linked to decreased risk of venous thrombosis reduces binding. And binding triggers NETosis!
Check out movie 7 - so clear to see the SLC44A2 dependent adhesion of leukocytes to platelets, and the impact of the polymorphism. I love platelet papers for views like those! Looking forward to more biochemistry on the SLC44A2-integrin interaction, but overall very solid paper.
